Human papillomavirus infection and oral squamous cell carcinoma - a systematic review

Melo, Bernardo Augusto de Carvalho; Vilar, Luisa Gallo; Oliveira, Natália Rodrigues; Lima, Priscila Oliveira de; Pinheiro, Melina de Barros; Domingueti, Caroline Pereira; Pereira, Michele Conceição

doi:10.1016/j.bjorl.2020.10.017

Cited by 38 publications

(43 citation statements)

References 33 publications

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“…This supports previous research that community acceptability towards HPV vaccination is a slow process that requires first acknowledging rumors, fears, and concerns, prior to expressing the benefits and safety of HPV vaccination [41]. This review supports prior research that calls for strategies to first address prominent misinformation about HPV vaccination in the SSA context prior to HPV vaccination campaign roll out [13,14,16,26,41], highlighting that HPV vaccination decision-making is complex and multifactorial [60,61].…”

Section: Discussionsupporting

confidence: 82%

“…This is aligned with the broader research examining the feminization of HPV due to the focus on cervical cancer screening, which has not only made females the primary group responsible for HPV prevention, but has also resulted insufficient protection from HPV-related illnesses in males and females alike [ 55 , 56 , 57 , 60 ]. This review also supports the broader literature of gendered disparities in HPV vaccination uptake by sex being consistent with the delayed recommendation for boys to also get the HPV vaccine, and today, further evident in a lack of coverage for boys in many National Insurance Programs with conflicting messages around gender norms as both a barrier and facilitator to HPV vaccination uptake [ 55 , 56 , 57 , 60 , 61 ].…”

Section: Discussionsupporting

confidence: 80%

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Stakeholders’ Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review

2021

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Cervical cancer rates in Sub-Saharan Africa (SSA) are amongst the highest worldwide. All three of the Human Papillomavirus (HPV) vaccines (9-valent, quadrivalent and bivalent HPV vaccine) provide primary protection against the most common cancer-causing strains of HPV (types 16 and 18) that are known to cause 70% of cervical cancers. Over the last five years, there has been an increase in Sub-Saharan African countries that have introduced the HPV vaccine. The majority of research has been conducted on supply-side barriers and facilitators to HPV vaccination uptake in SSA, yet little research has been conducted on demand-side or end-user perspectives of, and decisions around, HPV vaccination. In order to complement existing research, and inform current and future HPV vaccination implementation approaches, this qualitative systematic review explored Stakeholders’ understandings of HPV vaccination in SSA. This review searched the following databases: Embase (via Scopus), Scopus, MEDLINE (via PubMed), PubMed, EBSCOhost, Academic Search Premier, Africa-Wide Information, CINAHL, PsycARTICLES, PsycINFO, SocINDEX, Web of Science, and the Cochrane Controlled Register of Trials (CENTRAL) and found a total of 259 articles. Thirty-one studies were found eligible for inclusion and were analyzed thematically using Braun and Clarke’s methods for conducting a thematic analysis. The quality of included studies was assessed using the Critical Appraisal Skills Programme (CASP) checklist. Three major themes emerged from this analysis; knowledge of HPV vaccination and cervical cancer is intertwined with misinformation; fear has shaped contradictory perceptions about HPV vaccination and gender dynamics are relevant in how stakeholders understand HPV vaccination in SSA.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 80%

Stakeholders’ Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review

2021

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“…Viral infections with high-risk human papillomavirus (HPV) were also identified as a risk factor for oral cancer by a relatively high percentage of dentists in the present study, although HPV is mainly known as a risk factor for oropharyngeal cancers [ 39 ] and not for oral cancers [ 40 ]. While HPV has been identified in around 70–90% of oropharyngeal cancer cases, the average prevalence of HPV-positive oral cancer was estimated at 4.4% in a systematic review evaluating the prevalence of HPV-positive OSCC using E6/E7 mRNA expression analysis [ 40 ]. This low prevalence of HPV-positive OSCC challenges the view that HPV is a possible etiological factor in oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus and Armenia: a multi-country cross-sectional study

et al. 2021

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Introduction Moldova, Belarus, and Armenia are post-Soviet countries with a high rate of heavy smokers and a relatively high age-standardized incidence of oral cancer. However, to our knowledge, there is lack of available information on dentists’ knowledge on prevention of oral cancer in the countries in question. Accordingly, this study aimed to assess the knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus, and Armenia. Methods This was a multi-country, cross-sectional study based on a self-administered questionnaire. A structured questionnaire was distributed to 3534 dentists (797 in Chisinau, Moldova, 1349 in Minsk, Belarus, and 1388 in Yerevan, Armenia). Dentists' knowledge about risk factors for oral cancer development and its clinical picture, current practices and opinions with regard to oral mucosal screening and oral cancer prevention, and their consistency to perform oral mucosal examination were assessed. A knowledge score ranging from 0 to 14 points was generated based on each dentist’s answer to the questionnaire. Results A total of 1316 dentists responded, achieving an overall response rate of 37.2% (34.5% in Moldova; 52.3% in Belarus; 24.2% in Armenia). Most dentists in the three countries correctly identified tobacco (83.8–98.2%) and prior oral cancer lesions (84.0–96.3%) as risk factors for oral cancer. Most dentists correctly identified leukoplakia as a lesion with malignant potential (68.7% in Moldova; 88.5% in Belarus; 69.9% in Armenia), while erythroplakia was identified by much fewer in all three countries. Less than 52% of dentists identified the tongue, rim of tongue, and floor of mouth as the most common sites for oral cancer. The mean knowledge score for all countries combined was 7.5 ± 2.7. The most commonly reported barriers to perform oral mucosal examination were lack of training, knowledge, and experience. Conclusions This study highlights the need for improved oral cancer-related education and training on oral mucosal examination for dentists in Moldova, Belarus, and Armenia. Such skills are essential to enhance oral cancer prevention and to improve the prognostic outcome by early detection.

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“…It was also discovered that HPV infection increased the probability of OSCC development in the Chinese population (OR 12.7, 95% CI: 8.0–20.0) by more than 12 times [ 44 ]. However, a recent meta-analysis published by Melo et al (2021) found E6/E7 mRNA expression in only 4.4% of OSCCs [ 45 ]. HPV16 and 18 are the most frequent HPV genotypes detected in these tumors [ 45 , 46 ].…”

Section: Epidemiology Of Hpv/ebv Coinfection In Hnsccsmentioning

confidence: 99%

“…However, a recent meta-analysis published by Melo et al (2021) found E6/E7 mRNA expression in only 4.4% of OSCCs [ 45 ]. HPV16 and 18 are the most frequent HPV genotypes detected in these tumors [ 45 , 46 ]. In addition, the presence of HPV16 has been related to an increased histological grade of oral tumors [ 47 ].…”

Section: Epidemiology Of Hpv/ebv Coinfection In Hnsccsmentioning

confidence: 99%

High-Risk Human Papillomavirus and Epstein–Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

Blanco

Carrillo-Beltrán

Corvalán

et al. 2021

Biology

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High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.

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Human papillomavirus infection and oral squamous cell carcinoma - a systematic review

Cited by 38 publications

References 33 publications

Stakeholders’ Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review

Stakeholders’ Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review

Knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus and Armenia: a multi-country cross-sectional study

High-Risk Human Papillomavirus and Epstein–Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

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