Impact of resection margin status and revision transoral laser microsurgery in early glottic cancer: analysis of organ preservation and local disease control on a cohort of 153 patients

Saraniti, Carmelo; Montana, Francesca; Chianetta, Enzo; Greco, G.; Verro, Barbara

doi:10.1016/j.bjorl.2020.09.008

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…Today, the detection of this virus in the oral cavity and oropharynx is very frequent, with a prevalence ranging between 40 and 90% according to studies [ 27 , 28 ]. In particular, the main factors related to high incidence of HPV infection in these sites are: aged between 40 and 60 years, male, white race, numerous sexual partners, and oral sex [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Verro¹,

Gallina²,

Saraniti³

2022

IJERPH

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Human papillomavirus is a sexually transmitted virus that is responsible not only for uterine cervical cancer, but also for the oral and oropharyngeal cancers. In this latter case, the virus indiscriminately affects both sexes at any age. Vaccination plays a key role in preventing infection and its possible consequences. Therefore, this study aimed to assess the degree of awareness of papillomavirus infection and its possible prevention in the Sicilian population. A prospective observational study was carried out on the Sicilian population through a self-administered questionnaire, consisting of 10 multiple-choice questions. The survey lasted from June 2021 to December 2021. A total of 844 respondents were included: 60.90% were female and 53.55% were aged between 21 and 30 years. Most of the surveyed population knew about the virus and the existence of the vaccine, however, many of them did not know about virus’s effects on the oral and oropharyngeal sites (49.17%), or about the indication for vaccination for males (39.69%). Oral and oropharyngeal papillomavirus-related cancers are an increasingly frequent finding, especially in young adults. Therefore, it is necessary and quite mandatory to educate the population about the risks that certain voluptuous habits may cause, with the help of general practitioners, schools, social media, and social networks.

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Section: Discussionmentioning

confidence: 99%

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Verro¹,

Gallina²,

Saraniti³

2022

IJERPH

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“…In their study, Page et al [17] found some factors that relates to a statistically significant risk of local recurrence: age, lymph node positivity (N+), positive resection margin, other synchronous cancer. Furthermore, in their study, they underlined that the main risk factor for local recurrence (and, therefore, a negative prognostic factor) is the positive or close resection margins (healthy tissuecarcinoma distance <1 mm), especially the inferior margin [43]. For this reason, to guarantee a safe surgery, Page et al stated that resection margins had to be superior to 1 mm and subglottic extension inferior to 10 mm.…”

Section: Primary Ophl Type IImentioning

confidence: 99%

Oncological Outcomes of Primary vs. Salvage OPHL Type II: A Systematic Review

Saraniti

Verro

Ciodaro

et al. 2022

IJERPH

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Background: Open partial horizontal laryngectomy type II (OPHL type II) has two main aims: oncological radicality and laryngeal preservation. The aim of this review is to define and emphasize the oncological efficacy of OPHL type II, both as primary and salvage surgery, by analyzing the latest literature. Methods: The research was carried out on Pubmed, Scopus and Web of Science databases, by using strict keywords. Oncological outcomes were evaluated by the following parameters: overall survival, disease-specific survival, disease-free survival, local control, laryngeal preservation, local recurrence. Results: The review included 19 articles divided into three groups: (1) primary OPHL type II, (2) salvage OPHL type II, (3) adjuvant radiotherapy after primary OPHL type II. The articles showed excellent results as far as oncological radicality and organ preservation. Conclusions: This review demonstrated that OPHL type II is useful to obtain oncological radicality both as primary surgery and salvage surgery. Nevertheless, the only criterion that determined the positive outcome and efficacy of this technique is the strict selection of patient and tumor.

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“…2 For Stage I-II glottic LSCC treated with transoral laser microsurgery, surgical margin positivity rates have been reported to be between 12.0% and 45.4%. [3][4][5][6][7][8][9][10][11][12] Previous literature has conflicted on the prognostic impact of surgical margin positivity for early-stage LSCC. Several studies have reported that positive surgical margins are associated with higher rates of local recurrence, [3][4][5][6] mortality, 13 and disease progression, 13 lower rates of organ preservation 5,6 and local control, 5 and worse diseasespecific 5,8,14,15 and disease-free survival.…”

Section: Introductionmentioning

confidence: 99%

“…Achieving negative pathologic surgical margins is believed to be an important consideration to reduce both the necessity for additional treatments, such as adjuvant treatment and re‐operation, and the risk of recurrence 2 . For Stage I‐II glottic LSCC treated with transoral laser microsurgery, surgical margin positivity rates have been reported to be between 12.0% and 45.4% 3–12 …”

Section: Introductionmentioning

confidence: 99%

The impact of undergoing surgical margin evaluation during endoscopic surgery for early‐stage laryngeal squamous cell carcinoma

Gilja,

Kumar,

Vasan

et al. 2023

Head & Neck

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BackgroundThe impact of evaluating versus not evaluating surgical margins for early‐stage laryngeal squamous cell carcinoma (LSCC) has not been evaluated.MethodsOverall survival was compared between patients who underwent endoscopic surgery for cT1‐2, N0, M0 LSCC and had surgical margins evaluated versus not evaluated versus unevaluable in the National Cancer Database (2010–2019) using multivariable‐adjusted Cox proportional hazards analyses.Results7597 patients met study eligibility criteria. 4123 (54.3%) patients underwent margin evaluation, 1631 (21.5%) did not undergo margin evaluation, and 1843 (24.3%) had unevaluable margins. Patients undergoing margin evaluation had better overall survival than patients who did not undergo margin evaluation (HR: 0.88, 95% CI: 0.78–1.00, p = 0.044) and patients with unevaluable margins (HR: 0.88, 95% CI: 0.78–0.98, p = 0.021). Patients undergoing margin evaluation received significantly less adjuvant radiation.ConclusionsSurgical margin evaluation is an important prognostic factor for patients receiving endoscopic surgery for early‐stage LSCC and should be conducted whenever possible.

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Impact of resection margin status and revision transoral laser microsurgery in early glottic cancer: analysis of organ preservation and local disease control on a cohort of 153 patients

Cited by 6 publications

References 31 publications

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study

Oncological Outcomes of Primary vs. Salvage OPHL Type II: A Systematic Review

The impact of undergoing surgical margin evaluation during endoscopic surgery for early‐stage laryngeal squamous cell carcinoma

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