Laryngo-tracheobronchial amyloidosis

Uyaguari, Juan Pablo; Quizhpe, P.J.; Lima, Evelise

doi:10.1016/j.bjorl.2020.07.006

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…The indication for speech therapy follows a similar curve in all 3 cleft groups with a peak during the years immediately preceding school enrollment. While the high need for speech therapy in patients with clefting of the hard and soft palate is in accordance with numbers found in literature (Sell et al, 2001;Rezaei et al, 2020), the only slightly lower numbers in patients without affection of the palate is surprising. In 2021, Smarius et al published their results of a prospective study evaluating the need for speech therapy in a cohort of patients with CL only, finding that in 24% of patients speech therapy was indicated and concluding that there is no higher risk of speech problems compared to the general population (Smarius et al, 2021).…”

Section: Discussionsupporting

confidence: 87%

Continuous Multidisciplinary Care for Patients With Orofacial Clefts—Should the Follow-up Interval Depend on the Cleft Entity?

Sander

Grau

Kloss‐Brandstätter

et al. 2021

The Cleft Palate-Craniofacial Journal

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Objective The multidisciplinary follow-up of patients with cleft lip with or without palate (CL/P) is organized differently in specialized centers worldwide. The aim of this study was to evaluate the different treatment needs of patients with different manifestations of CL/P and to potentially adapt the frequency and timing of checkup examinations accordingly. Design We retrospectively analyzed the data of all patients attending the CL/P consultation hour at a tertiary care center between June 2005 and August 2020 ( n = 1126). We defined 3 groups of cleft entities: (1) isolated clefts of lip or lip and alveolus (CL/A), (2) isolated clefts of the hard and/or soft palate, and (3) complete clefts of lip, alveolus and palate (CLP). Timing and type of therapy recommendations given by the specialists of different disciplines were analyzed for statistical differences. Results Patients with CLP made up the largest group ( n = 537), followed by patients with cleft of the soft palate ( n = 371) and CL ± A ( n = 218). There were significant differences between the groups with regard to type and frequency of treatment recommendations. A therapy was recommended in a high proportion of examinations in all groups at all ages. Conclusion Although there are differences between cleft entities, the treatment need of patients with orofacial clefts is generally high during the growth period. Patients with CL/A showed a similarly high treatment demand and should be monitored closely. A close follow-up for patients with diagnosis of CL/P is crucial and measures should be taken to increase participation in follow-up appointments.

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Section: Discussionsupporting

confidence: 87%

Continuous Multidisciplinary Care for Patients With Orofacial Clefts—Should the Follow-up Interval Depend on the Cleft Entity?

Sander

Grau

Kloss‐Brandstätter

et al. 2021

The Cleft Palate-Craniofacial Journal

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Laryngotracheobronchial amyloidosis: A case report

Duc

et al. 2021

Respiratory Medicine Case Reports

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Primary laryngotracheobronchial amyloidosis is a rare pulmonary disease that can cause endobronchial stenosis. This disease has never previously been reported in Vietnam. We aimed to report a laryngotracheobronchial amyloidosis case in a 43-year-old female, which may be the first reported case in Vietnam. The patient had a 4-year history of progressive hoarseness, dyspnea, and hemoptysis. Multiple bronchial biopsies combined with detailed clinical information suggested an amyloidosis disease. Red congo staining was positive in bronchial samples, and a further workup found positive red congo staining in subcutaneous fatty tissue biopsy samples. Tracheostomy was performed due to severe dyspnea related to laryngeal stenosis. A multidisciplinary consultation was held, and chemotherapy with melphalan and dexamethasone were prescribed due to the systemic effects of the disease. After 2 cycles of chemotherapy, the patient showed improvement in dyspnea and cough. Due to the inexperience of both the clinicians and pathologists, this case was diagnosed quite late. In the future, if this diagnosis is considered in the differential diagnosis, an earlier diagnosis and better treatment outcome can be reached.

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Laryngo-tracheobronchial amyloidosis

Cited by 2 publications

References 5 publications

Continuous Multidisciplinary Care for Patients With Orofacial Clefts—Should the Follow-up Interval Depend on the Cleft Entity?

Continuous Multidisciplinary Care for Patients With Orofacial Clefts—Should the Follow-up Interval Depend on the Cleft Entity?

Laryngotracheobronchial amyloidosis: A case report

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