Prognostic factors and overall survival in a 15-year followup of patients with malignant salivary gland tumors: a retrospective analysis of 193 patients

Filho, Osias Vieira de Oliveira; Rêgo, Talita Jordânia Rocha do; Mendes, Felipe Herbert de Oliveira; Dantas, Thinali Sousa; Cunha, Maria do Perpétuo Socorro Saldanha da; Malta, Cássia Emanuella Nóbrega; Silva, Paulo Goberlânio de Barros; Sousa, Fabrício Bitú

doi:10.1016/j.bjorl.2020.06.016

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Herein, MEC accounted for 42.3% of all PC cases, and we exhibited that the risk of CSD in persons with MEC was not remarkably higher relative to that in other types of PC such as adenoid cystic carcinoma and polymorphous adenocarcinoma, adenocarcinoma NOS, and myoepithelial carcinoma. This is consistent with the result of Filho OVO et in a retrospective analysis of 193 patients ( 25 ). Nevertheless, Baddour et al.…”

Section: Discussionsupporting

confidence: 93%

“…documented that sex had no effect on cancer-distinct survival of PC patients, which is congruent with our work ( 24 ). The findings also showed that histology type and N stage were independent indicators for PC patients, which is in agreement with previous findings in malignant salivary gland tumor research ( 25 ). To prevent overfitting, the aforementioned factors were omitted using PC to improve the performance of the model.…”

Section: Discussionsupporting

confidence: 92%

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Nomogram Predicting Cancer-Specific Death in Parotid Carcinoma: a Competing Risk Analysis

et al. 2021

Front. Oncol.

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PurposeMultiple factors have been shown to be tied to the prognosis of individuals with parotid cancer (PC); however, there are limited numbers of reliable as well as straightforward tools available for clinical estimation of individualized mortality. Here, a competing risk nomogram was established to assess the risk of cancer-specific deaths (CSD) in individuals with PC.MethodsData of PC patients analyzed in this work were retrieved from the Surveillance, Epidemiology, and End Results (SEER) data repository and the First Affiliated Hospital of Nanchang University (China). Univariate Lasso regression coupled with multivariate Cox assessments were adopted to explore the predictive factors influencing CSD. The cumulative incidence function (CIF) coupled with the Fine-Gray proportional hazards model was employed to determine the risk indicators tied to CSD as per the univariate, as well as multivariate analyses conducted in the R software. Finally, we created and validated a nomogram to forecast the 3- and 5-year CSD likelihood.ResultsOverall, 1,467 PC patients were identified from the SEER data repository, with the 3- and 5-year CSD CIF after diagnosis being 21.4% and 24.1%, respectively. The univariate along with the Lasso regression data revealed that nine independent risk factors were tied to CSD in the test dataset (n = 1,035) retrieved from the SEER data repository. Additionally, multivariate data of Fine-Gray proportional subdistribution hazards model illustrated that N stage, Age, T stage, Histologic, M stage, grade, surgery, and radiation were independent risk factors influencing CSD in an individual with PC in the test dataset (p < 0.05). Based on optimization performed using the Bayesian information criterion (BIC), six variables were incorporated in the prognostic nomogram. In the internal SEER data repository verification dataset (n = 432) and the external medical center verification dataset (n = 473), our nomogram was well calibrated and exhibited considerable estimation efficiency.ConclusionThe competing risk nomogram presented here can be used for assessing cancer-specific mortality in PC patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Nomogram Predicting Cancer-Specific Death in Parotid Carcinoma: a Competing Risk Analysis

et al. 2021

Front. Oncol.

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“…Findings indicate clinical factors such as histopathological type and grade of lesion, advanced tumor stage, facial nerve involvement, vascular invasion, lymph node metastasis, and distant metastasis, negatively affect prognosis [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. In addition, demographic factors such as gender or age are also factors that affect prognosis [ 14 , 26 , 31 , 34 , 36 ]. Assessing survival and risk of recurrence is extremely important for both clinicians and patients.…”

Section: Introductionmentioning

confidence: 99%

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Žůrek

Jasak

Jaros

et al. 2022

IJERPH

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(1) Background: Malignant tumours of the salivary glands have different clinical and histopathological characteristics. They most commonly involve the parotid gland. Histopathologically, the most common are mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (AdCC), acinic cell carcinoma (AcCC), adenocarcinoma, carcinoma in pleomorphic adenoma (CPA), and squamous cell carcinoma (SCC). (2) Methods: We analysed 2318 patients with malignant parotid gland tumours reported to the National Cancer Registry (NCR) in Poland over 20 years (1999–2018). The demographic characteristics of patients, clinical factors, and overall survival (OS) were analysed. (3) Results: The average age was 61.33 ± 16.1 years. The majority were males (55%) and urban citizens (64%). High percentage of carcinomas was diagnosed in locoregional (33.7%) and systemic (10.4%) stadium. The most prevalent diagnoses were SCC (33.3%) and adenocarcinoma (19.6%). Surgical resection with adjuvant RT (42.1%) was the most common treatment. The OS analysis showed a median survival time of 5.6 years. The most favorable median OS was found in patients with AcCC (18.30 years), the worst for SCC (1.58 years). (4) Conclusion: AcCC has the best prognosis and SCC the worst. Tumour stadium, treatment, and demographic factors affect prognosis. Improvements in diagnosis and re-evaluation of treatment standards are necessary to enhance the outcome of patients with parotid gland cancers in Poland.

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Outcomes of Oral and Oropharyngeal Squamous Cell Carcinoma Related to Healthcare Coverage: A Retrospective Cohort Study in Brazil

Dantas

Sousa

Sales

et al. 2022

Cancer Investigation

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Prognostic factors and overall survival in a 15-year followup of patients with malignant salivary gland tumors: a retrospective analysis of 193 patients

Cited by 6 publications

References 32 publications

Nomogram Predicting Cancer-Specific Death in Parotid Carcinoma: a Competing Risk Analysis

Nomogram Predicting Cancer-Specific Death in Parotid Carcinoma: a Competing Risk Analysis

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Outcomes of Oral and Oropharyngeal Squamous Cell Carcinoma Related to Healthcare Coverage: A Retrospective Cohort Study in Brazil

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