Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods

Prognostic factors and a dynamic model on cancer‐specific survival for T1aN0M0 glottic cancer: A population‐based analysis and clinical validation

“…12 And multivariate Cox analysis confirmed that age (HR = 0.120, 95% CI = 0.035-0.410, p = .001) was an independent prognostic factor. 12 In our study, age was also proved to be a high-risk factor for the prognosis of patients with T 1a N 0 M 0 glottic cancer, which decreased the CSS. The reason may be that the immunity and resistance of patients always decreased with increasing age, and most elder patients may be accompanied by cardiopulmonary dysfunction or other organic diseases.…”

“…an independent high-risk prognostic factor. 12 Luo et al's multivariate Cox analysis showed that grade (HR = 2.07, 95% CI = 1.22-3.51, p = .007) was an independent prognostic factor affecting the CSS of patients of T 1a glottic cancer. 17 Based on the data of the American cancer database from 2010 to 2015, Anderson et al proved that grade is an important prognostic factor of head and neck cancer, and the prognosis of patients would be worse with the increase of grade level.…”

“…Lane et al followed up on 87 patients with primary T is‐2 N 0 M 0 glottic cancer after laser surgery, indicating that age was an important prognostic factor and younger patients (age < 62 years old) might have better voice function recovery 11 . Wang et al analysed 144 cases of T is‐2 N 0 M 0 glottic cancer retrospectively, proving that elder patients (≥60 years old) may have a worse 5‐year survival rate than younger patients (<60 years old) ( p = .022) 12 . And multivariate Cox analysis confirmed that age (HR = 0.120, 95% CI = 0.035–0.410, p = .001) was an independent prognostic factor 12 .…”

“…Wang et al analysed 144 cases of T is‐2 N 0 M 0 glottic cancer retrospectively, proving that elder patients (≥60 years old) may have a worse 5‐year survival rate than younger patients (<60 years old) ( p = .022) 12 . And multivariate Cox analysis confirmed that age (HR = 0.120, 95% CI = 0.035–0.410, p = .001) was an independent prognostic factor 12 . In our study, age was also proved to be a high‐risk factor for the prognosis of patients with T 1a N 0 M 0 glottic cancer, which decreased the CSS.…”

“…The third important independent prognostic factor was grade. Wang et al's retrospective study showed that patients with high and moderate differentiation might have a better 5‐year survival rate than those with low differentiation ( p < .001), and Cox multivariate analysis showed that grade (HR = 3.88, 95% CI = 1.32–11.40, p = .01) was an independent high‐risk prognostic factor 12 . Luo et al's multivariate Cox analysis showed that grade (HR = 2.07, 95% CI = 1.22–3.51, p = .007) was an independent prognostic factor affecting the CSS of patients of T 1a glottic cancer 17 .…”