Correlation of PET-CT, MRI and histopathology findings in the follow-up of patients with nasopharyngeal cancer

Ak, Semih; Kılıç, Caner; Özlügedik, Samet

doi:10.1016/j.bjorl.2019.12.004

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…Therefore, trimodality appears to be a technique of choice in the treatment of cancer in radiotherapy. It provides anatomical and functional information of high spatial resolution and allows improving the definition of target volumes in radiotherapy ( 10 – 12 ). A summary of the advantages and disadvantages of CT, MRI, and PET separately and combined in PET/CT/MRI is presented in Table 1 .…”

Section: Technical Partsmentioning

confidence: 99%

Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review

Decazes

Hinault

Veresezan³

et al. 2021

Front. Oncol.

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Computed tomography (CT) has revolutionized external radiotherapy by making it possible to visualize and segment the tumors and the organs at risk in a three-dimensional way. However, if CT is a now a standard, it presents some limitations, notably concerning tumor characterization and delineation. Its association with functional and anatomical images, that are positron emission tomography (PET) and magnetic resonance imaging (MRI), surpasses its limits. This association can be in the form of a trimodality PET/CT/MRI. The objective of this mini-review is to describe the process of performing this PET/CT/MRI trimodality for radiotherapy and its potential clinical applications. Trimodality can be performed in two ways, either a PET/MRI fused to a planning CT (possibly with a pseudo-CT generated from the MRI for the planning), or a PET/CT fused to an MRI and then registered to a planning CT (possibly the CT of PET/CT if calibrated for radiotherapy). These examinations should be performed in the treatment position, and in the second case, a patient transfer system can be used between the PET/CT and MRI to limit movement. If trimodality requires adapted equipment, notably compatible MRI equipment with high-performance dedicated coils, it allows the advantages of the three techniques to be combined with a synergistic effect while limiting their disadvantages when carried out separately. Trimodality is already possible in clinical routine and can have a high clinical impact and good inter-observer agreement, notably for head and neck cancers, brain tumor, prostate cancer, cervical cancer.

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Section: Technical Partsmentioning

confidence: 99%

Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review

Decazes

Hinault

Veresezan³

et al. 2021

Front. Oncol.

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“…At present, CT and MRI are commonly applied for the clinical diagnosis of NPC [9]. CT technology gives a lower resolution of soft tissue images, whereas MRI can clearly show the tumor site, invasion range, and lymph node metastasis [10].…”

Section: Introductionmentioning

confidence: 99%

Convolutional Neural Network in Evaluation of Radiotherapy Effect for Nasopharyngeal Carcinoma

Hai-feng

Fang

2022

Scientific Programming

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This study was aimed to explore the adoption value of magnetic resonance imaging (MRI) under convolutional neural networks (CNN) in the therapeutic effect of nasopharyngeal carcinoma (NPC) radiotherapy. A total of 54 NPC patients were recruited. CNN was employed to perform 3D visualization processing on magnetic resonance (MR) images of NPC patients. MRI changes were analyzed before and after the patient received radiotherapy. The image segmentation and radiotherapy effects of CNN were evaluated by the Recall, intersection over union (IOU), postoperative apparent diffusion coefficient (ADC), and diagnostic coincidence rate. Moreover, gradient vector flow (GVF) algorithm, fuzzy c-means (FCM), and SegNet were adopted for comparative evaluation. Recall of CNN was 94.89% and the IOU was 84.16%, which was remarkably different from other algorithms (P < 0.05). After analysis of the MRI images of patients receiving radiotherapy, ADC of local residual patients was 1.108 ± 0.097 measured by CNN, the ADC was 1.826 ± 0.115, and the missed diagnosis rate was only 7.14%. In summary, CNN had a good effect on the localization and segmentation of NPC patients, and can accurately evaluate the effect of patients receiving radiotherapy, which can assist clinical diagnosis and treatment of NPC.

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“…Trimodality imaging (PET, CT, and MRI) has improved the definition of GTVs 15–20 . However, no single medical device allows the acquisition of all three imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

Characterization of positioning uncertainties in PET‐CT‐MR trimodality solutions for radiotherapy

Hinault

Gardin

Gouel

et al. 2022

J Applied Clin Med Phys

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The purpose of this study was to evaluate the positioning uncertainties of two PET/CT‐MR imaging setups, C1 and C2. Because the PET/CT data were acquired on the same hybrid device with automatic image registration, experiments were conducted using CT‐MRI data. In C1, a transfer table was used, which allowed the patient to move from one imager to another while maintaining the same position. In C2, the patient stood up and was positioned in the same radiotherapy treatment position on each imager. The two setups provided a set of PET/CT and MR images. The accuracy of the registration software was evaluated on the CT‐MRI data of one patient using known translations and rotations of MRI data. The uncertainties on the two setups were estimated using a phantom and a cohort of 30 patients. The accuracy of the positioning uncertainties was evaluated using descriptive statistics and a t‐test to determine whether the mean shift significantly deviated from zero (p < 0.05) for each setup. The maximum registration errors were less than 0.97 mm and 0.6° for CT‐MRI registration. On the phantom, the mean total uncertainties were less than 2.74 mm and 1.68° for C1 and 1.53 mm and 0.33° for C2. For C1, the t‐test showed that the displacements along the z‐axis did not significantly deviate from zero (p = 0.093). For C2, significant deviations from zero were present for anterior‐posterior and superior‐inferior displacements. The mean total uncertainties were less than 4 mm and 0.42° for C1 and less than 1.39 mm and 0.27° for C2 in the patients. Furthermore, the t‐test showed significant deviations from zero for C1 on the anterior‐posterior and roll sides. For C2, there was a significant deviation from zero for the left‐right displacements.This study shows that transfer tables require careful evaluation before use in radiotherapy.

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Correlation of PET-CT, MRI and histopathology findings in the follow-up of patients with nasopharyngeal cancer

Cited by 7 publications

References 20 publications

Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review

Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review

Convolutional Neural Network in Evaluation of Radiotherapy Effect for Nasopharyngeal Carcinoma

Characterization of positioning uncertainties in PET‐CT‐MR trimodality solutions for radiotherapy

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