Top-cited articles in cerebrospinal fluid leak (rhinorrhea and otorrhea) (1945–2018)

Case report: Recurrent spontaneous cerebrospinal fluid (CSF) leak

“…The etiology of spontaneous cerebrospinal leak is still not fully understood. However, increased intracranial pressure could be contributing factor for spontaneous CSF rhinorrhea [1] , [3] , [13] , [14] . Although endoscopic repair can achieve almost 90 % success rate for CSF leak, the success rate for spontaneous cerebrospinal fluid leak were much worse [15] .…”

“…Cerebrospinal Fluid (CSF) is a clear aqueous solution that, compared with plasma, contains higher concentrations of sodium, chloride, and magnesium and lower concentrations of glucose, proteins, amino acids, uric acid, potassium, bicarbonate, calcium, and phosphate. Cerebrospinal fluid (CSF) leak describes the discharge of CSF from the intracranial cavity through an osseous defect(s) within the mucosa, skull base and meningeal membrane [1] .…”