The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma

Al‐Hakami, Hadi; Garni, Mohammed A Al; AlSubayea, Haya; Alotaibi, Yazeed; Neazy, A.; Jameel, Waed; Albouq, Mohammed; Alnufaie, A.; Fatani, Nawaf

doi:10.1016/j.bjorl.2019.11.003

Cited by 10 publications

(12 citation statements)

References 26 publications

(45 reference statements)

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“…Both had subglottic involvement by the primary tumor, suggesting that TGI was by direct extension of the cancer. 6 A multicenter study from Malaysia reported 3 out of 72 (4.2%) patients to have thyroid gland infiltration on histology. All three patients had subglottic or transglottic disease with evident thyroidal invasion preoperatively.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Thyroid Gland Invasion by Laryngeal Squamous Cell Carcinoma: The Role of Subglottic Extension

Pasha

Wasif

Ikram

et al. 2022

Int Arch Otorhinolaryngol

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Introduction Management of the thyroid gland during laryngectomy has been controversial. The primary tumor may invade the thyroid gland by direct invasion or lymphovascular spread. Hypothyroidism and hypoparathyroidism are potential risks when lobectomy or total thyroidectomy are performed simultaneously. Objective To report the frequency of thyroid gland involvement by primary laryngeal squamous cell carcinoma in patients undergoing laryngectomy and to identify possible risk factors for thyroid gland involvement so that judicious excision of thyroid gland can be attained. Methods We performed a retrospective review of 9 years. Data was collected from medical records of patients dated from December 2009 to October 2018. All patients with laryngeal cancer who underwent laryngectomy with lobectomy or total thyroidectomy were included in the present study. Results We reviewed 151 laryngectomy records. A total of 130 surgeries included the thyroid gland with the excised specimen and were available for analysis. There were 124 males and 6 females. The mean age was 59.4 years old. The glottis was the most common subsite involved, in 70 patients, followed by 38 transglottic, 16 supraglottic and 03 subglottic tumors. On histology, 12 out of 130 excised thyroid glands were involved by squamous cell carcinoma. Only subglottic involvement (p = 0.01) was significantly associated with thyroid gland invasion (TGI). Type of laryngectomy, subsite of the primary tumor, thyroid cartilage involvement, neck nodal metastases, and perineural and lymphatic invasion by the primary tumor were not associated with TGI. Conclusion Only subglottic involvement is associated with TGI; therefore, preoperative and intraoperative assessment is necessary prior to considering excision of the thyroid gland.

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Section: Discussionmentioning

confidence: 99%

Frequency of Thyroid Gland Invasion by Laryngeal Squamous Cell Carcinoma: The Role of Subglottic Extension

Pasha

Wasif

Ikram

et al. 2022

Int Arch Otorhinolaryngol

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“…Therefore, thyroid parenchymal invasion may be seen through direct invasion or LVI in advanced stage LSCC. [25] The prevalence of thyroid gland involvement in the presence of advanced stage LSCC ranges between 1-30% in the literature. [25 , 26] Without nationality differentiation, 56% of the patients included in our study were undergone thyroidectomy and 1 (2%) of those patients had thyroid parenchymal invasion.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Gürsoy

Seçinti

DORAN>

et al. 2022

Journal of Contemporary Medicine

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Objectives: This study aimed to identify the differences between the tumors and their histopathological characteristics in the materials obtained by laryngectomy performed because of laryngeal squamous cell carcinoma (LSCC) in Turkish and Syrian patient populations. Material and Method: Our study has a retrospective design. The present study included all the patients who were diagnosed with squamous cell carcinoma between January 2010 to January 2021 and underwent laryngectomy in our institute. Medical records, pathology and radiology reports were reviewed. Demographic and histopathological factors were statistically compared between Turkish and Syrian groups. Results: Of 93 cases included in our study, 53 (57%) were Syrian while 40 (43%) were Turkish citizens. We have determined no statistically significant difference between two patient groups. Conclusions: Hatay is a geography that Syrians were familiar with its culture before the war and both societies are exposed to the same environmental conditions. Therefore, we might have found no significant difference between the demographic and histopathological characteristics of laryngeal cancer in Turkish and Syrian patient populations.

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“…41 In contrast, it is up to 57% in hypopharyngeal carcinomas. 8,11,17-19,21,24 To our knowledge, there are no published data focused on TGI in SL. In our study, 38 of 51 (74.5%) patients who underwent SL also had TThy, HThy, or isthmusectomy.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of thyroid gland invasion (TGI) in laryngeal cancer varies between 1% and 30%. 8-10 There is controversy about the extent of the thyroidectomy in primary laryngectomy. Some authors advocate that the standard surgical treatment should be to perform a total laryngectomy (TL) and ipsilateral hemithyroidectomy (HThy) or isthmusectomy.…”

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Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

Brunet

Tornari

Ezebuiro

et al. 2021

Otolaryngol.--head neck surg.

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Objective Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design Case series with chart review. Setting Department of Otorhinolaryngology, Head and Neck Surgery, Guy’s Hospital, London, United Kingdom. Methods A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.

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The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma

Cited by 10 publications

References 26 publications

Frequency of Thyroid Gland Invasion by Laryngeal Squamous Cell Carcinoma: The Role of Subglottic Extension

Frequency of Thyroid Gland Invasion by Laryngeal Squamous Cell Carcinoma: The Role of Subglottic Extension

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

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