The effect of epidermal growth factor on the pseudo-healing of traumatic tympanic membrane perforations

Lou, Zhengcai

doi:10.1016/j.bjorl.2019.06.011

Cited by 11 publications

(9 citation statements)

References 26 publications

(42 reference statements)

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“…In addition, there were no significant differences between EGF alone and Gelfoam patching in closure rate (97.8% vs. 86.7%, respectively, P = 0.039) or average closure time (11.12 ± 4.60 vs. 13.67 ± 5.379 days, P = 0.071) [ 44 ]. However, Lou [ 46 ] used EGF alone to treat 24 adult chronic traumatic perforations and reported a closure rate of 100% within 6.1 ± 2.3 days.…”

Section: Resultsmentioning

confidence: 99%

“…However, 26 articles did not meet the inclusion criteria, and only the remaining 47 articles were included in the analysis. Of the 47 papers, 18 were experimental studies of the effects of FGF2 or EGF in repair of acute or chronic perforations [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Table 1), 16 were clinical studies in human acute perforations (FGF2 in 11 and EGF in 5) [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] (Table 2), nine were clinical studies in human chronic perforations (FGF2 in eight and EGF in one) [47][48][49][50][51][52][53][54][55] (Table 3), and four papers examined the dose-and time-dependent effects of FGF2 or EGF on human and...…”

Section: Resultsmentioning

confidence: 99%

“…Five clinical studies of the effects of EGF on acute perforations were from China [42][43][44][45][46]; two were randomized controlled trials (RCTs), two were prospective studies, and the remaining one was a retrospective study. Only one RCT of the effects of EGF on the regeneration of human chronic perforations was found.…”

Section: Resultsmentioning

confidence: 99%

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FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Lou¹,

Lou

Jiang

et al. 2021

Stem Cells International

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Objective. A systematic review was conducted to compare the effectiveness and safety of fibroblast growth factor-2 (FGF2) and epidermal growth factor (EGF) for regeneration of the tympanic membrane (TM). Methods. The PubMed database was searched for relevant studies. Experimental and clinical studies reporting acute and chronic TM perforations in relation to two healing outcomes (success rate and closure time) and complications were selected. Results. A total of 47 studies were included. Five experimental studies showed closure rates of 55%–100% with FGF2 compared with 10%–62.5% in controls for acute perforations. Five experimental studies showed closure rates of 30.3%–100% with EGF and 3.6%–41% in controls for chronic perforations. Two experimental studies showed closure rates of 31.6% or 85.7% with FGF2 and 15.8% or 100% with EGF. Nine clinical studies of acute large perforations showed closure rates of 91.4%–100% with FGF2 or EGF. Two clinical studies showed similar closure rates between groups treated with FGF2 and EGF. Seven clinical studies showed closure rates of 88.9%–100% within 3 months and 58%–66% within 12 months using FGF2 in repair of chronic perforations, but only one study showed a significantly higher closure rate in the saline group compared with the FGF2 group (71.4% vs. 57.5%, respectively, P = 0.547 ). In addition, three experimental studies showed no ototoxicity associated with FGF2 or EGF. No middle ear cholesteatoma or epithelial pearls were reported, except in one experimental study and one clinical study, respectively. Conclusions. FGF2 and EGF showed good effects and reliable safety for the regeneration of TM. In addition, EGF was better for the regeneration of acute perforations, while FGF2 combined with biological scaffolds was superior to EGF for chronic perforations, but was associated with high rates of reperforation over time. Further studies are required to determine whether EGF or FGF2 is better for TM regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Lou¹,

Lou

Jiang

et al. 2021

Stem Cells International

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“… Biomolecule Results Model TM perforation Refs. EGF 100% closure rate range 3–12 days Human Chronic [68] EGF 96.2% closure rate range 3–14 days Human Subacute [69] Fat graft soaked in PRP Increase in adipocyte area, decrease in granulation tissue area in comparison to fat graft alone Rat Acute [70] FGF-2 98.1% closure for non-pathological TMP, 10.1 ± 4.6 days Human Not specified [71] 86.7% closure rate for pathological TMP, 19.1 ± 7.3 days 1% HyA topical application 52% closure Human Acute and chronic, 1–3 mm [15] 36% TMP size reduction. Time of closure not specified EGF and FGF-2 EGF – 91.11% closure rate 9-16.5 days Human Acute dry [72] FGF-2 – 93.18% closure rate 7-15 days Human Insulin Accelerated healing, 100% closure 5-7days.…”

Section: Strategies Focusing On Growth Factors/biomoleculesmentioning

confidence: 99%

Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations

Sainsbury

Amaral

Blayney

et al. 2022

Biomaterials and Biosystems

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“…EGF protects the zone of stasis tissue from burn damage [79]. It can also correct the pseudo-healing of traumatic tympanic membrane perforations, after daily application over six months, to keep the membrane moist [80]. In patients with diabetic foot ulcers, parenteral administration of EGF on epithelial tissue has a positive effect on the healing process [81].…”

Section: Epidermal Growth Factor and Wound Healingmentioning

confidence: 99%

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

Miricescu

Bădoiu

Stănescu-Spînu

et al. 2021

IJMS

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Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.

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The effect of epidermal growth factor on the pseudo-healing of traumatic tympanic membrane perforations

Cited by 11 publications

References 26 publications

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

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