Stem-cell therapy for hearing loss: are we there yet?

Dufner-Almeida, Luiz Gustavo; Cruz, Dayane Bernardino da; Mingroni-Netto, Regina Célia; Batissoco, Ana Carla; Oiticica, Jeanne; Salazar-Silva, Rodrigo

doi:10.1016/j.bjorl.2019.04.006

Cited by 14 publications

(9 citation statements)

References 46 publications

(67 reference statements)

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“…Two approaches for the delivery of exogenous stem cells have been reported, including into the scala tympani through the round window, or cochleostomy, and inducing them to migrate into the organ of Corti; direct injection into the scala media and optimizing the survival of the transplanted cells [51]. The differentiated cells could interact with hair cells and auditory neurons of cochlear explants via formation of new synapses [52]. Current challenges in stem cell transplantation are cell survival and differentiation after transplantation, especially in the scala media of the cochlea, which contains high potassium endolymph.…”

Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

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Otorhinolaryngology enrolls head and neck surgery in various tissues such as ear, nose, and throat (ENT) that govern different activities such as hearing, breathing, smelling, production of vocal sounds, the balance, deglutition, facial animation, air filtration and humidification, and articulation during speech, while absence of these functions can lead to high morbidity and even mortality. Conventional therapies for head and neck damaged tissues include grafts, transplants, and artificial materials, but grafts have limited availability and cause morbidity in the donor site. To improve these limitations, regenerative medicine, as a novel and rapidly growing field, has opened a new therapeutic window in otorhinolaryngology by using cell transplantation to target the healing and replacement of injured tissues. There is a high risk of rejection and tumor formation for transplantation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs) lack these drawbacks. They have easy expansion and antiapoptotic properties with a wide range of healing and aesthetic functions that make them a novel candidate in otorhinolaryngology for craniofacial defects and diseases and hold immense promise for bone tissue healing; even the tissue sources and types of MSCs, the method of cell introduction and their preparation quality can influence the final outcome in the injured tissue. In this review, we demonstrated the anti-inflammatory and immunomodulatory properties of MSCs, from different sources, to be safely used for cell-based therapies in otorhinolaryngology, while their achievements and challenges have been described too.

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Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

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“…There are three types of stem cells in cell regeneration that consist of Embryonic Stem Cells (ESCs), adult stem cells, and Induced Pluripotent Stem Cells (IPSCs) [24]. These cells can present cellular markers of otic progenitor cells in vitro using special protocols and activation of some known signals.…”

Section: The Types Of Stem Cell In Hearing Regenerationmentioning

confidence: 99%

Stem Cell Therapy in Children With Sensorineural Hearing Loss: A Narrative Review

Oroei

Ahadi

2021

J. Pediatr. Rev

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Context: One of the research areas is using stem cell transplantation for treating children’s sensorineural hearing loss. Preclinical studies and testing of the stem cell types have been performed in this field, and relative improvement has been achieved. Objectives: This narrative review has been prepared to study the advancements in hearing regeneration with stem cell transplantation. Data Sources: The English articles with full-text were searched in PubMed, Scopus, and Google scholar from 2000 to 2020 using keywords of sensory neural hearing loss and stem cell. Results: In 2018, the first human study was performed with stem cells from the human umbilical cord, which has promising results regarding the safety of the method and its positive effects on hearing. Conclusions: Autologous stem cell transplantation had induced relative improvement without serious adverse events in children with acquired sensorineural hearing loss. To obtain more evidence, further studies are required with larger sample sizes and in different patients groups.

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“…Given the capacity of pluripotent stem cells (PSCs) to selfrenew and differentiate into many cell types, they are now widely used in regenerative medicine (Okano and Kelley, 2012). The stem cells commonly used are embryonic stem cells (ESCs), adult stem cells (ASCs), and iPSC (Dufner-Almeida et al, 2019). Oshima et al (2010) adapted the protocol and promoted the differentiation of mouse ESCs and iPSC into mechanosensitive HC-like cells.…”

Section: Stem Cells and Three-dimensional Organoidsmentioning

confidence: 99%

Usher Syndrome: Genetics and Molecular Links of Hearing Loss and Directions for Therapy

Whatley

Francis

et al. 2020

Front. Genet.

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Usher syndrome (USH) is an autosomal recessive (AR) disorder that permanently and severely affects the senses of hearing, vision, and balance. Three clinically distinct types of USH have been identified, decreasing in severity from Type 1 to 3, with symptoms of sensorineural hearing loss (SNHL), retinitis pigmentosa (RP), and vestibular dysfunction. There are currently nine confirmed and two suspected USH-causative genes, and a further three candidate loci have been mapped. The proteins encoded by these genes form complexes that play critical roles in the development and maintenance of cellular structures within the inner ear and retina, which have minimal capacity for repair or regeneration. In the cochlea, stereocilia are located on the apical surface of inner ear hair cells (HC) and are responsible for transducing mechanical stimuli from sound pressure waves into chemical signals. These signals are then detected by the auditory nerve fibers, transmitted to the brain and interpreted as sound. Disease-causing mutations in USH genes can destabilize the tip links that bind the stereocilia to each other, and cause defects in protein trafficking and stereocilia bundle morphology, thereby inhibiting mechanosensory transduction. This review summarizes the current knowledge on Usher syndrome with a particular emphasis on mutations in USH genes, USH protein structures, and functional analyses in animal models. Currently, there is no cure for USH. However, the genetic therapies that are rapidly developing will benefit from this compilation of detailed genetic information to identify the most effective strategies for restoring functional USH proteins.

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Stem-cell therapy for hearing loss: are we there yet?

Cited by 14 publications

References 46 publications

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Stem Cell Therapy in Children With Sensorineural Hearing Loss: A Narrative Review

Usher Syndrome: Genetics and Molecular Links of Hearing Loss and Directions for Therapy

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