Osteoporosis and hearing loss: findings from the Korea National Health and Nutrition Examination Survey 2009–2011

Yoo, Jun‐Il; Park, Sun-Hee; Seo, Sung-Hyo; Park, Hyun Woo

doi:10.1016/j.bjorl.2018.12.009

Cited by 7 publications

(5 citation statements)

References 22 publications

(20 reference statements)

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“…The protein product of Pth1r can be agonized by abaloparatide and teriparatide, both approved for the treatment of osteoporosis. Osteoporosis has been associated with elevated auditory thresholds in a large population cohort study [75]. Countering osteoporotic effects might have a protective effect on age-related decline of hearing thresholds.…”

Section: Drugs Poised For Repurposing To Treat Age-related Loss Of Co...mentioning

confidence: 90%

Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss

2022

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Age-related hearing loss (ARHL) or presbycusis is a prevalent condition associated with social isolation, cognitive impairment, and dementia. Age-related changes in the cochlea, the auditory portion of the inner ear, are the primary cause of ARHL. Unfortunately, there are currently no pharmaceutical approaches to treat ARHL. To examine the biological processes underlying age-related changes in the cochlea and identify candidate drugs for rapid repurposing to treat ARHL, we utilized bulk RNA sequencing to obtain transcriptomes from the functional substructures of the cochlea—the sensorineural structures, including the organ of Corti and spiral ganglion neurons (OC/SGN) and the stria vascularis and spiral ligament (SV/SL)—in young (6-week-old) and old (2-year-old) C57BL/6 mice. Transcriptomic analyses revealed both overlapping and unique patterns of gene expression and gene enrichment between substructures and with ageing. Based on these age-related transcriptional changes, we queried the protein products of genes differentially expressed with ageing in DrugBank and identified 27 FDA/EMA-approved drugs that are suitable to be repurposed to treat ARHL. These drugs target the protein products of genes that are differentially expressed with ageing uniquely in either the OC/SGN or SV/SL and that interrelate diverse biological processes. Further transcriptomic analyses revealed that most genes differentially expressed with ageing in both substructures encode protein products that are promising drug target candidates but are, nevertheless, not yet linked to approved drugs. Thus, with this study, we apply a novel approach to characterize the druggable genetic landscape for ARHL and propose a list of drugs to test in pre-clinical studies as potential treatment options for ARHL.

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Section: Drugs Poised For Repurposing To Treat Age-related Loss Of Co...mentioning

confidence: 90%

Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss

2022

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“…The occurrence time of abnormal bone metabolism of TS is about 20-30 years earlier than that of normal women, and the risk of fracture is about 25% higher than that of normal people (50, 51). Previous studies have found that osteoporosis and low BMD can lead to HL, which may be associated with abnormal bone metabolism in the temporal bone, including loss of bone mass in the ossicular chain in the middle ear and osseous structures in the inner ear such as the bone labyrinth (15)(16)(17)52). Yueniwati (53) found that BMD of cochlea, ossicles, femur or spine was negatively correlated with hearing threshold, indicating that abnormal bone metabolism may lead to HL.…”

Section: Discussionmentioning

confidence: 99%

“…TS patients often also have endocrine abnormalities, metabolic disease and abnormal bone metabolism. Studies have shown that low bone mineral density (BMD), thyroid dysfunction and metabolic syndrome are risk factors for HL (12)(13)(14)(15)(16)(17), and timely supplementation of thyroid hormone or lowering of blood lipids can improve hearing. However, it is not known if this association also exists in women with TS.…”

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confidence: 99%

Incidence and risk factors of hearing loss in patients with Turner Syndrome

Lin

Wang²,

Qin³

et al. 2023

Front. Public Health

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BackgroundHearing loss (HL) is one of the main medical complications for Turner Syndrome (TS) patients, with an earlier presentation and higher incidence than normal women. However, the etiology of HL in TS is unclear. The aim of this study was to investigate the hearing status of TS patients in China and the influencing factors, so as to provide a theoretical basis for early intervention treatment for TS patients with HL.MethodsIn total 46 female patients aged 14–32 diagnosed with TS received tympanic membrane and audiological examinations, including pure tone audiometry and tympanometry. In addition, the effects of karyotype, sex hormone levels, thyroid function, insulin, blood lipids, bone mineral density, age and other factors on hearing levels were analyzed, and the possible risk factors associated with HL in TS patients were explored.ResultsIn 9 patients (19.6%) had HL, including 1 (2.2%) with mild conductive hearing loss, 5 (10.9%) with mild sensorineural hearing loss, 3 (6.5%) with moderate sensorineural hearing loss. TS is often associated with age-related mid-frequency and high-frequency HL, and the incidence of HL increases with age. Compared with other karyotypes, patients with 45, X haplotype have an increased risk of mid-frequency HL.ConclusionsTherefore, karyotype may be a predictor of hearing problems in TS.

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“…40 One cross-sectional study in the Korea Health and Nutrition Examination Survey found no association between femoral neck or lumbar spine bone density measurements and hearing loss, 39 but another found higher odds of hearing loss among those with lower femoral neck BMD and no association with femoral shaft or lumbar spine BMD. 41 Increased bone resorption coupled with decreased bone formation causes reductions in bone mass quantity and bone quality leading to compromised bone strength and increased risk of fractures. As a complement to our analyses of osteoporosis, we also examined whether VF or HF, the most common osteoporosis-related fractures, was associated with risk of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

“…A cross‐sectional study among ~2000 participants (1082 women) in The Health, Aging and Body Composition Study found lower total hip BMD was associated with higher odds of hearing loss among black men ( n = 310; odds ratio [OR]: 1.36 [1.05, 1.75]), but not white men ( n = 660; OR: 0.86 [0.72, 1.03]); no associations between bone density and hearing loss in women were observed 40 . One cross‐sectional study in the Korea Health and Nutrition Examination Survey found no association between femoral neck or lumbar spine bone density measurements and hearing loss, 39 but another found higher odds of hearing loss among those with lower femoral neck BMD and no association with femoral shaft or lumbar spine BMD 41 …”

Section: Discussionmentioning

confidence: 99%

Osteoporosis, bisphosphonate use, and risk of moderate or worse hearing loss in women

Curhan

Stanković

Halpin

et al. 2021

J American Geriatrics Society

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Background: Osteoporosis and low bone density (LBD) may be associated with higher risk of hearing loss, but findings are inconsistent and longitudinal data are scarce. Bisphosphonates may influence risk, but the relation has not been studied in humans. We longitudinally investigated associations of osteoporosis and LBD, bisphosphonate use, vertebral fracture (VF), hip fracture (HF), and risk of self-reported moderate or worse hearing loss.

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Osteoporosis and hearing loss: findings from the Korea National Health and Nutrition Examination Survey 2009–2011

Cited by 7 publications

References 22 publications

Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss

Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss

Incidence and risk factors of hearing loss in patients with Turner Syndrome

Osteoporosis, bisphosphonate use, and risk of moderate or worse hearing loss in women

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