Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss?

Öcal, Ruhşen; Öçal, Fatma Ceyda Akın; Güllüev, Mustafa; Alataş, Necat

doi:10.1016/j.bjorl.2018.10.007

Cited by 13 publications

(18 citation statements)

References 24 publications

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“…Selection based on title and abstract screening led to the exclusion of 57 studies. The 33 remaining studies potentially relevant to the topic were accurately examined and, after full-text screening and application of inclusion/exclusion criteria, 13 articles were included in the qualitative synthesis (see Figure 1 ) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Subsequently, 9 articles were included in the quantitative synthesis [ 11 , 13 , 14 , 15 , 16 , 19 , 20 , 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…All included studies had adequate relevance to the subject of this systematic review. No studies were a randomized controlled trial; five out of thirteen were retrospective studies [ 11 , 12 , 13 , 16 , 17 ] and eight prospective ones [ 14 , 15 , 18 , 19 , 20 , 21 , 22 , 23 ]. Randomization, concealed allocation, and baseline comparability were not achieved in company study and according to the NOS scale [ 10 ], and the quality of included case-control studies was overall moderate or high, ranging from 5 to 9 stars out of nine (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Randomization, concealed allocation, and baseline comparability were not achieved in company study and according to the NOS scale [ 10 ], and the quality of included case-control studies was overall moderate or high, ranging from 5 to 9 stars out of nine (see Table 1 ). A main issue was the poor selection of controls: only 4 studies enrolled community controls [ 15 , 17 , 18 , 22 ], whereas all the others selected hospital controls, with potential ongoing pathologies perhaps responsible for alterations of the studied biomarkers [ 11 , 12 , 13 , 14 , 16 , 19 , 20 , 21 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…The more investigated markers were CRP and CRP/albumin ratio [ 11 , 12 , 13 , 16 , 17 , 19 ]; TNF-α [ 13 , 14 , 15 , 19 , 20 , 22 , 23 ]; High Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) [ 13 , 18 ]; Inflammatory cells Neutrophil (N), leucocyte (L) and monocytes (M) [ 13 , 16 , 17 , 19 , 20 , 21 ]. Other studied markers were ESR [ 13 , 21 ]; Anti Cyclic Citrullinated Peptides (CCP) [ 21 ]; Anti Double Strand (DS) DNA [ 21 ]; Complement (C) 3 and C4 factor [ 21 ]; Q10 Coenzyme [ 18 ]; Procalcitonin [ 11 ]; IL 6, 10 and 12 [ 19 , 23 ]; Cholesterol [ 18 ]; Natural Killer Cell Activity (NKCA) [ 19 ]; Cluster of Differentiation (CD) 40 and CD86 [ 13 , 20 ]; Nuclear Factor Kappa-light-chain-enhancer of activated B cells (NFKB) [ 15 ]; Toll Like Receptor (TLR)4 [ 15 ]; Anti-Nuclear Antibody (ANA) [ 14 , 15 ]; Interferon-γ [ 20 ]; Nervonic Acid [ 18 ] anti Heat Shock Protein (HSP) 70 [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

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Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis

et al. 2022

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Background and Objectives: Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatment and hearing recovery. The main aim of this systematic review and meta-analysis was to assess and critically discuss the role of circulating inflammatory biomarkers in SSNHL. Materials and Methods: A search was conducted of the English literature published between 1 January 2009 and 7 July 2022 on Pubmed, Scopus, Web of Science, ScienceDirect, and Cochrane following PRISMA guidelines. Results: A total of 256 titles were retrieved from the search. After full-text screening and application of inclusion/exclusion criteria, 13 articles were included. Twelve out of thirteen studies reported significant differences in biomarkers values in SSNHL patients, of which Tumor Necrosis Factor alpha (TNF-α) and C-reactive Protein (CRP) were the most analyzed. Our meta-analysis for CRP’s mean values in SSNHL groups vs. controls showed significantly higher CRP levels with a pooled overall difference of 1.07; confidence interval (CI) at 95%: 0.03; 2.11. For TNF-α, discordant results were found: three studies showed significantly higher levels in SSNHL patients vs. controls, whereas other three investigations showed lower levels in the SSNHL groups (overall pooled difference 1.97; 95% CI: −0.90; 4.84). A high between-study heterogeneity was found. Conclusions: This systematic review pointed out that, although there exists a growing literature in the field of circulatory biomarkers identification in SSNHL, there is a high heterogeneity of results and low quality of evidence. CRP resulted to be higher in SSNHL patients than in controls, while TNF-α showed more heterogeneous behavior. The data reported herein needs to be confirmed in well-designed prospective multicenter randomized studies, with the objective of improving SSNHL treatment and outcome and thereby reducing the social burden of hearing loss.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis

et al. 2022

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“…This ratio did not differ significantly between patients who did and did not respond to treatment but was lower in responders. Taken together, these findings suggest that the CRP/Alb ratio may be a prognostic marker of SSNHL [ 42 ].…”

Section: Biomarkers In Ssnhlmentioning

confidence: 96%

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

Doo

Kim

et al. 2020

IJMS

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Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies.

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The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis

Chen

Wang

Zhang

et al. 2022

Eur Arch Otorhinolaryngol

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Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss?

Cited by 13 publications

References 24 publications

Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis

Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis

Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss

The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis

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