Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

Ito, Taku; Ikeda, Satoshi; Asamori, Tomoaki; Honda, Keiji; Kawashima, Yasunaru; Kitamura, Ken; Suzuki, Keiko; Tsutsumi, Takeshi

doi:10.1016/j.bjorl.2018.07.005

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…Primary ciliary dyskinesia may also be the reason for mucociliary clearance disabilities [ 1 ]. Additionally, the eosinophilic endotype of CRSwNP is characterized by increased levels of two main airway mucins that are involved in mucous formulation (MUC5AC and MUC5B) and of the anion exchanger pendrin [ 5 , 6 , 7 ]. Increased MUC5AC expression and GC metaplasia were also observed in human CRS sinonasal tissue in response to cigarette smoke exposure [ 8 ].…”

Section: Immunological Response Pathways In Crsmentioning

confidence: 99%

Immunological Aspects of Chronic Rhinosinusitis

et al. 2022

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Chronic rhinosinusitis (CRS) is related to persistent inflammation with a dysfunctional relationship between environmental agents and the host immune system. Disturbances in the functioning of the sinus mucosa lead to common clinical symptoms. The major processes involved in the pathogenesis of CRS include airway epithelial dysfunctions that are influenced by external and host-derived factors which activate multiple immunological mechanisms. The molecular bases for CRS remain unclear, although some factors commonly correspond to the disease: bacterial, fungal and viral infections, comorbidity diseases, genetic dysfunctions, and immunodeficiency. Additionally, air pollution leads increased severity of symptoms. CRS is a heterogeneous group of sinus diseases with different clinical courses and response to treatment. Immunological pathways vary depending on the endotype or genotype of the patient. The recent knowledge expansion into mechanisms underlying the pathogenesis of CRS is leading to a steadily increasing significance of precision medicine in the treatment of CRS. The purpose of this review is to summarize the current state of knowledge regarding the immunological aspects of CRS, which are essential for ensuring more effective treatment strategies.

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Section: Immunological Response Pathways In Crsmentioning

confidence: 99%

Immunological Aspects of Chronic Rhinosinusitis

et al. 2022

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“…This problem can be solved by the inhalation method of intranasal GCSs, the main purpose of which is to act directly at the site of the pathological process with a larger contact area (Hong and Kim 2019). According to (Ito et al 2019), up to 8% of the drug penetrates into the paranasal cavity and remains there for a long time. Now there are nebulizers available for delivery of medicines, including GCSs, which are actively used in medical practice (Wang et al 2019).…”

Section: Treatmentmentioning

confidence: 99%

Modern approaches to the treatment of chronic polypous rhinosinusitis

Bairashevskaia¹,

Kytko²,

Vasil’ev³

et al. 2020

RRP

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Introduction: Today, chronic polypous rhinosinusitis (CPR) occupies a special place among otolaryngological diseases, the incidence rate of which increases every year. To date, the main causes of chronic polypous rhinosinusitis are Staphylococcus aureus and anatomical abnormalities. Diagnostics: Knowledge of a universal algorithm for the diagnosis of this disease, consisting of the collection of anamnesis, endoscopic examination of the nasal cavity, computed tomography of the paranasal sinuses, anterior active rhinomanometry and bacteriological determination of the microbial spectrum, allows diagnosing chronic polyposis rhinosinusitis in time, and, as a consequence, to prescribe a treatment. Treatment: This review describes conservative therapies, including antibiotics and glucocorticosteroids. Today, the main task of doctors is to find the most effective method of administration of glucocorticosteroids to achieve the maximum effect. One of these methods is the introduction of the drug with the help of nebulizer, as in this case, the drug will remain in the perirhinal cavity for a long time and have the maximum effect due to the directed action only in the area of the pathological process. Features of chronic polypous rhinosinusitis in childhood: It should be noted that children under 12 years of age due to the formation of the paranasal sinuses at different stages of ontogenesis will be characterized by different forms of chronic polyposis rhinosinusitis. That is why they should be known and taken into account when making a diagnosis and prescribing a treatment. Conclusion: Today, the frequency of chronic rhinosinusitis increases exponentially, which makes the question of the modern approach to its treatment the most relevant. It is possible that additional research in this area will solve the issue of searching for both the optimal path of therapy and treatment of CPR in children.

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“…As previously illustrated, IL-17 acts synergistically with IL-13 to induce pendrin expression in HNE cells [92]. Recent studies showed a significant correlation between pendrin, MUC5AC, and eosinophil infiltration in nasal polyps of eosinophil chronic rhinosinusitis patients; nevertheless, almost half of the studied polyps did not present high levels of pendrin, thus leading to the speculation that IL-17 in combination with Th2 cytokines may be necessary for pendrin expression and mucus production in eosinophil chronic rhinosinusitis [134]. Put together, these data indicate a role for pendrin in mucus production and hyperplasia driven by allergic cytokines in airway epithelia, although the mechanism still needs to be completely elucidated.…”

Section: Pendrin In the Airwaysmentioning

confidence: 99%

Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia

Vanoni¹,

Scantamburlo²,

Dossena

et al. 2019

IJMS

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Pendrin (SLC26A4), a Cl−/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during inflammatory diseases leads to imbalances in airway surface liquid thickness and mucin release, while, in the esophageal epithelium, dysregulated pendrin expression is supposed to impact the intracellular pH regulation system. In this review, we discuss some of the recent findings on interleukin-mediated transcriptional regulation of pendrin and how this dysregulation impacts airway and esophagus epithelial homeostasis during inflammatory diseases.

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Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

Abstract: Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis.

Cited by 11 publications

References 28 publications

Immunological Aspects of Chronic Rhinosinusitis

Immunological Aspects of Chronic Rhinosinusitis

Modern approaches to the treatment of chronic polypous rhinosinusitis

Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia

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