Solitary plasmacytoma of the jaws: therapeutical considerations and prognosis based on a case reports systematic survey

Abstract

The occurrence of solitary bone plasmacytoma in the bones of the face is a rare condition prevalent between the 4th and 6th decades of life, located in the posterior region of the mandible in most cases. Histopathological examination and systemic investigation are mandatory for confirmation of diagnosis.

Diagnóstico e tratamento do plasmocitoma solitário ósseo em mandíbula / Diagnosis and treatment of solitary bone plasmacytoma in mandible

“…A cirurgia é indicada apenas para casos com risco de perda da motilidade de algum membro, como compressão da medula ou fratura iminente (1)(2)(4)(5)(6) , mas a radioterapia ainda é necessária (2) . A quimioterapia adjuvante não é tão benéfica comparada à RT (3) .…”

“…O plasmocitoma solitário (PS) pertence a um conjunto de desordens de células plasmáticas (2) , abrangendo menos de 5% das discrasias plasmáticas (1) . PS é definido como um tumor maligno de células plasmáticas monoclonais (2)(3)(4) que pode ser encontrado nos ossos, classificado como plasmocitoma solitário ósseo (PSO), ou nos tecidos moles, denominado de plasmocitoma solitário extramedular (PSE) (1)(2)(5)(6) .…”

Differenzialdiagnostische Erwägungen zur Periimplantitis

“…Therapeutisch können eine Radiotherapie, eine radikale chirurgische Resektion oder die Kombination beider Therapien zur Anwendung kommen. Bei Tumoren, die größer als 4-5 cm sind, kann die Durchführung einer adjuvanten Chemotherapie das Outcome verbessern [23]. Eine chirurgische Resektion sollte immer dann durchgeführt werden, wenn eine akute Frakturgefahr besteht.…”

Plasmacytoma and plasma cell myeloma affecting the jaws: A multi‐institutional collaborative study

“…4 Plasmacytomas are localized monoclonal plasma cell lesions, with no evidence of systemic involvement, 1 that can be classified as solitary bone plasmacytoma or extramedullary solitary plasmacytoma (when affecting soft tissues). [3][4][5] In the head and neck region, plasmacytomas most commonly affect the skull and jaw bones; however, 6,7 more than 50% of these patients will develop PCM within 2 years after their initial diagnosis, with involvement of multiple sites. 1,8 A PCM commonly causes osteolytic lesions in the axial skeleton, skull and pelvis, frequently leading to pathological fractures.…”