Clinical and polysomnographic predictors of laryngopharyngeal reflux in obstructive sleep apnea syndrome

Caparroz, Fábio de Azevedo; Campanholo, Milena de Almeida Torres; Regina, Caroline Gomez; Park, Sung Woo; Haddad, Leonardo; Gregório, Luiz Carlos; Haddad, Fernanda Louise Martinho

doi:10.1016/j.bjorl.2018.03.007

Cited by 16 publications

(19 citation statements)

References 22 publications

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“…A number of recent studies have investigated the prevalence of reflux in OSA patients but in almost all cases this was done using clinical questionnaires alone [9,10,11,12,13,14,15,16,17]. These aspects emerged in a recent meta-analysis of the international literature, which analyzed the incidence of LPR in OSA patients [18].…”

Section: Discussionmentioning

confidence: 99%

“…Over recent years, various studies have been published dealing with the correlation between laryngopharyngeal reflux (LPR) and OSA [9,10,11,12,13,14,15,16,17]. Although a high incidence of LPR in this class of patients has been reported [9,10,11,12,13,14,15,16,17], the possibility of a correlation between the severity of the pathology (number of hypopnea/apnea episodes) and LPR has not yet been clearly demonstrated [10,11,12,13,14,15,17].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, these tests are expensive, not easily applicable, and are often either not accepted or tolerated by patients [23,24,25]. Therefore, in clinical practice, a diagnosis based on endoscopic findings and clinical questionnaires is usually preferred [9,11,20,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

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Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Iannella

Vicini

Polimeni

et al. 2019

IJERPH

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Background: To investigate the presence of laryngopharyngeal reflux in patients with obstructive sleep apnea (OSA) employing the salivary pepsin concentration method. To compare the results of pepsin concentration with the severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31 females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea index) and the BMI (body mass index) were initially evaluated. All the patients enrolled were assessed using the reflux symptom index (RSI) and the reflux finding score (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. In all patients a salivary sample was taken to estimate the presence of pepsin and its concentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSA patients, evaluated using the salivary pepsin concentration test (PEP-test), was found to be 32% of cases. Linear regression testing did not show any correlation between AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: A high number of patients with OSA seem to show positivity for salivary pepsin, correlated to an LPR. There does not appear to be a correlation between the severity of apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens was observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Iannella

Vicini

Polimeni

et al. 2019

IJERPH

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“…There is a two-way regulatory effect between digestive function and brain in human body, that is, through the brain-gut axis and the sympathetic/parasympathetic nervous system, the central nervous system and the digestive system are closely linked to form a complete dynamic feedback loop to regulate biological rhythm and sleep state, so there is a correlation between sleep disorders and changes in digestive function ( 13 ). Changes of modern lifestyle disrupts the circadian rhythms, and sleep disorders has become an increasingly common problem.…”

Section: Discussionmentioning

confidence: 99%

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Liu

Xiao

et al. 2022

Front. Surg.

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ObjectiveTo observe the correlation between laryngopharyngeal reflux disease (LPRD) and patients' sleep status, and to explore the related factors of LPRD.MethodsFour hundred and sixteen patients who visited the otorhinolaryngology clinic in our hospital from June 2019 to June 2021 were selected as the research subjects. According to the scale of reflux symptom index, the subjects were divided into a patients group (120 patients) with an the reflux symptom index (RSI) > 13 and a control group (296 patients) with an RSI ≤ 13 according to the RSI scale score. General patient information was collected. The sleep state and emotional state of patients in the two groups were evaluated, and the related influencing factors for LPRD were also evaluated. The correlation between sleep state and depression in LPRD patients was analyzed.ResultsFour hundred and sixteen patients were divided into patients group and control group according to RSI score, the ratio of the two groups was 1:2.47. In the patients group, the common symptoms of RSI score and the top three of the total score were as follows: Foreign body sensation in throat in 112 patients, 438 points; Keep voice clear in 108 patients, 381 points; Excessive phlegm or nasal discharge reflux in 101 patients, 348 points. The PSQI and HADS scores in the patients group were higher than those in the control group (t = 19.990, 13.007, 14.690, P all <0.001). Logistic regression analysis showed that high-fat diet and high PSQI score were the risk factors for the development of LPRD (P = 0.012, P = 0.007). According to the PSQI score, the patients in the patients group were divided into 35 patients with abnormal PSQI score, 85 patients with normal PSQI score, and the HADS scores of those with abnormal PSQI score were all lower than those with normal PSQI score (P > 0.05). The PSQI score of the patients in the patients group was positively correlated with the HADS score (r = 0.714, P = 0.013).ConclusionSleep disorder may lead to the occurrence or aggravation of anxiety and depression in patients with LPRD, and it is an independent risk factor for the development of LPRD. Clinical attention to the treatment of sleep disorders in patients with LPRD may be conducive to improving the efficacy of LPRD.

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“…Gastric wall barrier structure and dysfunction, leading to reflux of gastric contents; (2) Obstructive sleep apnea hypopnea syndrome is 1 of the causes of Laryngopharyngeal Reflux. [ 2 ] The significant increase of negative thoracic pressure during the onset of the disease can cause gastric reflux and slow down the removal of reflux from the esophagus. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Proton pump inhibitors for the treatment of laryngopharyngeal reflux disease

et al. 2020

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Background: Laryngopharyngeal Reflux disease refers to abnormal reflux of gastric contents through the esophagus into the throat, which irritates and damages the pharyngeal mucosa, and causes corresponding symptoms. Proton Pump Inhibitors are an important class of gastric acid secretion inhibitors after H2 receptor blockers, which can be used clinically to treat peptic ulcer, abnormal gastric acid secretion and other related diseases. The common clinical drugs include omeprazole, lansoprazole, rabeprazole and so on. Clinical practice has shown that Proton Pump Inhibitors have a good therapeutic effect on Laryngopharyngeal Reflux disease, but evidence of evidence-based medicine is lacking. The purpose of this protocol is to systematically evaluate the efficacy and safety of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease and to improve the evidence-based basis for the clinical application of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease. Methods: English computer retrieval database (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese computer retrieval database (Wanfang Database, VIP Information Chinese Journal Service Platform, Chinese Biomedical Database) . In addition, Baidu Scholar and Google Scholar were manually searched for randomized controlled clinical studies on the treatment of laryngeal reflux disease with Proton Pump Inhibitors from the establishment of the database to July 2020. Two researchers independently extracted and evaluated the data of the included studies, and meta-analysis was conducted on the included literatures with RevMan5.3 software without language restrictions. Results: In this study, the efficacy and safety of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease are evaluated by the overall response rate, clinical symptom remission rate and other indicators. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of Proton Pump Inhibitors in the treatment of Laryngopharyngeal Reflux disease. OSF Registration number: DOI 10.17605 / OSF.IO / NY6SC

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Clinical and polysomnographic predictors of laryngopharyngeal reflux in obstructive sleep apnea syndrome

Cited by 16 publications

References 22 publications

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Proton pump inhibitors for the treatment of laryngopharyngeal reflux disease

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