Aging and wave-component latency delays in oVEMP and cVEMP: a systematic review with meta-analysis

Macambira, Ysa Karen dos Santos; Carnaúba, Aline Tenório Lins; Fernandes, Luciana Castelo Branco Camurça; Bueno, Nassib Bezerra; Menezes, Pedro de Lemos

doi:10.1016/j.bjorl.2016.12.006

Cited by 10 publications

(15 citation statements)

References 37 publications

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“…Therefore, it is indispensable to establish the normal range of BCV-induced VEMP for different age groups. Several previous studies have reported the influence of age on oVEMP and cVEMP parameters ( 17 , 24 , 25 , 27 – 31 ). Most studies showed a significant decline in the response rates, prolongation of latencies, and reduction of oVEMP and cVEMP amplitudes with increasing age ( 24 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Age-related morphological changes may occur in the vestibular system from the end organs to the central nuclei, including loss of hair cells, decreased numbers of vestibular nerve cells, and loss of neurons in the vestibular nucleus ( 20 – 23 ). Therefore, the effects of advancing age on the response rate, latency, and amplitude of ACS-VEMPs have been well explored ( 24 , 25 ). However, the age-related impact on the B81-VEMPs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

et al. 2022

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ObjectiveTo define the normal values and examine the influence of aging on B81 bone vibrator-induced cervical vestibular-evoked myogenic potentials (B81-cVEMPs) and ocular vestibular-evoked myogenic potentials (B81-oVEMPs).MethodsSeventy healthy subjects, divided into seven groups according to their ages, were enrolled in this study. The 4–9-, 10–19-, 20–29-, 30–39-, 40–49-, 50–59-, and 60–70-year-old participants were divided into groups I–VII, respectively. B81-cVEMP and B81-oVEMP were recorded in each group.ResultsThe B81-cVEMP response rates for groups I–VII were 100, 100, 100, 100, 95, 95, and 75%, respectively, with significant differences only between groups I–VI and group VII (p = 0.047, p < 0.05). The B81-oVEMP response rates for groups I–VII were 100, 100, 100, 100, 70, 65, and 40%, respectively, with significant differences only between groups I–IV and groups V–VII (p = 0.020, p = 0.008, p = 0.000; p < 0.05). The threshold, P13, and N23 latencies of B81-cVEMP positively correlated with age (r = 0.756, p = 0.000; r = 0.357, p = 0.003; r = 0.316, p = 0.009; p < 0.05). The raw amplitudes and corrected amplitudes negatively correlated with age (r = −0.641, p = 0.000; r = −0.609, p = 0.000, p < 0.05). For B81-oVEMP, the corrected amplitudes negatively correlated with age (r = −0.638, p = 0.000, p<0.05), but the threshold and N10 latency positively correlated with age (r = 0.768, p = 0.000; r = 0.334, p = 0.009, p < 0.05). Moreover, the interaural asymmetry ratio did not significantly correlate with age for B81-cVEMP and B81-oVEMP.ConclusionAs age increased, the B81-cVEMP response rate decreased, the thresholds increased, P13 and N23 latencies were prolonged, and the raw amplitude and corrected amplitude decreased. The B81-oVEMP response rate and corrected amplitude decreased, the thresholds increased, and N10 latency was prolonged with age. These changes are probably due to the occurrence of morphological and functional changes in the vestibular system with aging. Therefore, we suggest establishing different reference values according to different age groups when evaluating the VEMP results in patients with vestibular diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

et al. 2022

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“…The findings in this study are consistent with previous studies that showed prolonged latency, which may be associated with demyelination of axons (this reduces conduction velocity). 19,20 Macambira et al 21 reported that the latency component of oVEMP was delayed in older adults and it may be associated with a reduction in the number of neurons. Severe demyelination of axons due to OSAS may contribute to absent oVEMP responses because of conduction block.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 Macambira et al. 21 reported that the latency component of oVEMP was delayed in older adults and it may be associated with a reduction in the number of neurons. Severe demyelination of axons due to OSAS may contribute to absent oVEMP responses because of conduction block.…”

Section: Discussionmentioning

confidence: 99%

Vestibular-evoked myogenic potentials in patients with severe obstructive sleep apnea

et al. 2020

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Objective: Previous studies have shown that patients with obstructive sleep apnea syndrome (OSAS) may have various vestibular abnormalities, and these mainly present as subclinical lesions. In this study, we attempted to combine ocular vestibular-evoked myogenic potentials (VEMPs) and cervical (VEMPs) to investigate vestibular dysfunction in patients with OSAS. Methods: Thirty-eight patients with severe OSAS and 42 healthy controls were enrolled and divided into two groups according to results of polysomnography. All parameters of VEMP graphs were analyzed. Results: The response rate of ocular VEMPs was significantly lower in patients with severe OSAS (85.5%) than in controls (96.4%). The mean n1 latency of patients with severe OSAS (10.6 AE 1.0 months) was significantly longer than that of controls (10.2 AE 1.1 months). With regard to cervical VEMP, p1-n1 amplitudes were significantly different between the groups. Other VEMP parameters were not significantly different between the groups. Conclusions: VEMPs can potentially be used to evaluate vestibular system lesions at the early stage of OSAS, including not only the vestibular nerve, but also the otolith organs involved.

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“…Dentre as limitações do presente estudo está o escasso número de estudos que investigaram os limiares de resposta do VEMP, principalmente em indivíduos sem alterações otoneurológicas, dificultando assim a confirmação ou questionamento crítico mais aprofundado dos dados encontrados neste estudo 10,15,16,17,18,19,20,21 . Não foi possível realizar a comparação entre os sexos sobre os parâmetros do exame, devido à dificuldade em recrutar indivíduos do sexo masculino para o estudo.…”

Section: Conclusãounclassified

Análise das respostas do VEMP cervical e ocular em indivíduos hígidos

Ribeiro

Mancini

2021

Distúrb Comun

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Introdução: os potenciais evocados miogênicos vestibulares (VEMP) são respostas eletrofisiológicas que conseguem fornecer informações dos órgãos otolíticos sáculo, utrículo e do nervo vestibular. O VEMP é um exame complementar à avaliação vestibular, consistindo num exame rápido, de fácil aplicação e objetivo. Objetivo: analisar os parâmetros de latência, amplitude, limiar e índice de assimetria das respostas do VEMP cervical (cVEMP) e ocular (oVEMP) de indivíduos sem queixas vestibulares. Métodos: estudo transversal realizado com 53 indivíduos de ambos os sexos, sem queixas auditivas e vestibulares. Resultados: encontrou-se simetria de respostas nas latências, amplitudes e limiares de respostas do exame cVEMP. Entretanto, verificou-se diferença entre orelhas da latência P15 do exame oVEMP, sendo maior à direita no sexo feminino. Conclusão: Encontrou-se simetria nas respostas de todos os parâmetros avaliados do cVEMP. Houve assimetria apenas na latência de P15 do oVEMP no sexo feminino. Os limiares de resposta encontrados nos exames cVEMP e oVEMP foram iguais ou maiores que 75 dBNA.

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Aging and wave-component latency delays in oVEMP and cVEMP: a systematic review with meta-analysis

Abstract: The latency of oVEMP n1 wave component and latencies of cVEMP p13 and n23 wave components are longer in the elderly aged >60 years than in young adults.

Cited by 10 publications

References 37 publications

B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

Vestibular-evoked myogenic potentials in patients with severe obstructive sleep apnea

Análise das respostas do VEMP cervical e ocular em indivíduos hígidos

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