Intratympanic steroid injection and hyperbaric oxygen therapy for the treatment of refractory sudden hearing loss

Gülüstan, Filiz; Yazıcı, Zahide Mine; Alakhras, Wesam M.E.; Erdur, Ömer; Acıpayam, Harun; Küfeciler, Levent; Kayhan, Fatma Tülin

doi:10.1016/j.bjorl.2016.10.013

Cited by 12 publications

(17 citation statements)

References 25 publications

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“…The most commonly used salvage therapies for sudden hearing loss are HBO therapy and intratympanic steroid therapy [17][18][19][20][21] . A comparison of these two methods was recently described [22,23] .…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

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OBJECTIVE:To measure the effect of hyperbaric oxygen (HBO) therapy as salvage therapy after the failure of steroid therapy for sudden sensorineural hearing loss (SSNHL). MATERIALS and METHODS:Ninety-three patients with SSNHL were unsuccessfully treated with systemic steroid therapy. Following steroid therapy, 43 patients received additional HBO therapy while 50 did not. Hearing levels at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after therapy were measured. RESULTS:A significant difference in hearing thresholds after HBO therapy was found at all frequencies in patients with a hearing loss of >61 dB. The group of patients with a hearing threshold of ≤60 dB had a significant improvement only at 250 and 500 Hz, while group of patients without additional therapy control group showed no hearing improvement. CONCLUSION:Hyperbaric oxygen therapy therapy as salvage therapy for SSNHL showed some benefits in hearing improvement. Better results could be expected in patients with severe hearing loss, while in patients with mild-or-moderate hearing loss, recovery should be expected only at low frequencies.

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Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

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“…Gülüstan et al found no significant difference between HBOT and ITS when compared to each other. This study only took into account both therapies as individual entities and did not combine both treatments as proposed in the rationale for therapy [ 116 ].…”

Section: Clinical Use Of Hyperbaric Oxygen Therapymentioning

confidence: 99%

“…Younger patients (≤ 60 years) had significantly better improvement rateAjduk [134]2017ISSHLRSSS (presalvage)HBOT vs no therapy23 + 11.4YesNANANASignificant hearing improvements at 0.25; 0.5 and 8 kHz after HBOT. Significant hearing gains on all frequencies when hearing loss was > 60 dBLamm [152]2016ISSHLCRITS + HBOTNAYesNANANABeneficial effect of salvage HBOTAkil [117]2016ISSHLRSSS + HBOT4.1NoUni: 22.1Bi: 8.2Uni: 32.0Bi: 12.6NAUnilateral vs bilateral ISSHLNo effect of HBOT in bilateral hearing lossGülüstan [116]2016ISSHLRSITS vs HBOT11.3YesHBOT: 12.8ITS: 20.2HBOT: 21.1ITS: 28.3HBOT: 22.2ITS: 20.0No significant difference between HBOT and ITSV/d Wal [153]2016ISSHLCRHBOT monotherapy333 minNoNANA41.0HBOT resulted in hearing improvement in 80% of patientsKaratop-Cesur [132]2016ISSHLRSHBOT monotherapy6.8NoNANA53.8Better outcome with early treatment response (≥ 10 dB gain in the first week)Sherlock [135]…”

Section: Clinical Use Of Hyperbaric Oxygen Therapymentioning

confidence: 99%

The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review

Bayoumy

2019

Eur Arch Otorhinolaryngol

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Introduction Acute hearing loss can have a major impact on a patient’s life. This holds true for both acute acoustic trauma (AAT) and idiopathic sudden sensorineural hearing loss (ISSHL), two devastating conditions for which no highly effective treatment options exist. This narrative review provides the rationale and evidence for HBOT in AAT and ISSHL. Methods Narrative review of all the literature available on HBOT in acute hearing loss, studies were retrieved from systematic searches on PubMed and by cross referencing. Discussion First, the etiological mechanisms of acute hearing loss and the mechanism of action of HBOT were discussed. Furthermore, we have provided an overview of 68 studies that clinically investigated the effect of HBOT in the last couple of decades. For future studies, it is recommend to start as early as possible with therapy, preferably within 48 h and to use combination therapy consisting of HBOT and corticosteroids. Implications for practice HBOT has been used quite extensively for acute hearing loss in the last couple of decades. Based on the amount of studies showing a positive effect, HBOT should be discussed with patients (shared decision making) as optional therapy in case of AAT and ISSHL.

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“…ITS is a treatment method, which has an ongoing increase in popularity, minimizes the side effects of corticosteroids and enables achievement of therapeutic steroid concentrations with low doses. ITS is not only effective as a salvage therapy, but it also enables good results if it is combined with systemic corticosteroids during the primary treatment or administered as the primary treatment agent in patients, who cannot tolerate systemic steroids [81][82][83][84].…”

Section: Intratympanic Steroid Therapy (Its)mentioning

confidence: 99%

Sudden Sensorineural Hearing Loss

Acıpayam¹,

Koçak²,

Elbistanlı³

2018

An Excursus Into Hearing Loss

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Sudden hearing loss (SHL) is a common disease in the daily practice of ear-nose-throat (ENT) and audiology clinics. It is usually defined as a sensorineural type hearing loss of 30 dB or greater in three contiguous frequencies. Although several factors were suggested for the etiology of SHL, in most of the cases, no cause could be detected and they were diagnosed as idiopathic cases. Although certain specific treatments might be applied in patients with known etiology, corticosteroids are the main component in the treatment of idiopathic SHL. Many experts and centers have developed different treatment protocols with similar approaches. SHL is considered as an emergency in ENT, as it may cause a permanent loss in hair cells, if it is not treated or the treatment is not initiated at the right time. For patients, who did not or partially benefit from the initial treatment, different salvage treatment protocols had been developed. As SHL severely affects the patient's quality of life, its diagnosis and treatment should be thoroughly deliberated.

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Intratympanic steroid injection and hyperbaric oxygen therapy for the treatment of refractory sudden hearing loss

Abstract: ITS and HBO therapy produced similar improvements in SSNHL patients, but the sample size was too small to draw definitive conclusions. Further randomized controlled studies are needed to identify the best therapy for patients with refractory sudden hearing loss.

Cited by 12 publications

References 25 publications

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review

Sudden Sensorineural Hearing Loss

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