Hearing loss in congenital Zika virus

Wiwanitkit, Viroj

doi:10.1016/j.bjorl.2016.08.007

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…21 The most well-supported hypothesis of the mechanism for Zika-related HL is direct viral invasion of neurons in the auditory pathway. [77][78][79] The virus has been shown to have preference for undifferentiated neurons, which may explain the devastating complications resulting from congenital cases in comparison with adults and may serve as a possible explanation for the observed auditory neuropathy findings. 28,80 In contrast to the auditory neuropathy observed in Zika, HL associated with Ebola and LF is similar to common viral-mediated etiologies of HL and can be easily detected with traditional hearing screening.…”

Section: Discussionmentioning

confidence: 99%

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Ficenec

Schieffelin

Emmett

2019

The American Journal of Tropical Medicine and Hygiene

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The neglected tropical diseases Zika, Ebola, and Lassa fever (LF) have all been noted to cause some degree of hearing loss (HL). Hearing loss is a chronic disability that can lead to a variety of detrimental effects, including speech and language delays in children, decreased economic productivity in adults, and accelerated cognitive decline in older adults. The objective of this review is to summarize what is known regarding HL secondary to these viruses. Literature for this review was gathered using the PubMed database. Articles were excluded if there were no data of the respective viruses, postinfectious complications, or conditions related to survivorship. A total of 50 articles were included in this review. Fourteen articles discussing Zika virus and subsequent complications were included. Across these studies, 56 (21.2%) of 264 Zika-infected individuals were found to have HL. Twenty-one articles discussing Ebola virus and subsequent complications were included, with 190 (5.7%) of 3,350 Ebola survivors found to have HL. Fifteen additional articles discussing LF and subsequent complications were included. Of 926 individuals with LF, 79 (8.5%) were found to have HL. These results demonstrate a relationship between HL and infection. The true prevalence is likely underestimated, however, because of lack of standardization of reporting and measurement. Future studies of viral sequelae would benefit from including audiometric evaluation. This information is critical to understanding pathophysiology, preventing future cases of this disability, and improving quality of life after survival of infection.

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Section: Discussionmentioning

confidence: 99%

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Ficenec

Schieffelin

Emmett

2019

The American Journal of Tropical Medicine and Hygiene

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“…They classify as syndromic (10%) or non-syndromic (90%), the latter being autosomal recessive, autosomal dominant, or X-linked transmitted [ 3 ]. The acquired conditions refer to congenital infections such as CMV (cytomegalovirus), Zika virus, Rubella, and intrauterine exposure to toxins [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Congenital Cytomegalovirus-Related Hearing Loss

Gana,

Huluță,

Cătănescu

et al. 2024

Audiology Research

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Congenital hearing loss is a significant global health concern that affects millions of newborns and infants worldwide, posing substantial challenges for affected individuals, their families, and healthcare systems. This condition, present at birth, can stem from genetic factors, in utero exposures, infections, or complications during pregnancy or childbirth. The spectrum of congenital hearing loss ranges from mild to profound, impacting the development of speech, language, and cognitive skills, thereby influencing educational achievements, social integration, and future employment opportunities. Early detection and intervention strategies, such as newborn hearing screenings, genetic counseling, and the use of hearing aids or cochlear implants, are crucial for mitigating these impacts. This review article aims to explore the diagnostic approaches and management strategies for congenital cytomegalovirus-related hearing loss, emphasizing the importance of interdisciplinary care and the potential for technological advances to improve outcomes for affected individuals.

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Zika Virus: An Emerging Global Health Threat

Mittal

Nguyen

Debs

et al. 2017

Front. Cell. Infect. Microbiol.

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Zika virus (ZIKV) is an emerging healthcare threat. The presence of the mosquito Aedes species across South and Central America in combination with complementary climates have incited an epidemic of locally transmitted cases of ZIKV infection in Brazil. As one of the most significant current public health concerns in the Americas, ZIKV epidemic has been a cause of alarm due to its known and unknown complications. At this point, there has been a clear association between ZIKV infection and severe clinical manifestations in both adults and neonates, including but not limited to neurological deficits such as Guillain-Barré syndrome (GBS) and microcephaly, respectively. The gravity of the fetal anomalies linked to ZIKV vertical transmission from the mother has prompted a discussion on whether to include ZIKV as a formal member of the TORCH [Toxoplasma gondii, other, rubella virus, cytomegalovirus (CMV), and herpes] family of pathogens known to breach placental barriers and cause congenital disease in the fetus. The mechanisms of these complex phenotypes have yet to be fully described. As such, diagnostic tools are limited and no effective modalities are available to treat ZIKV. This article will review the recent advancements in understanding the pathogenesis of ZIKV infection as well as diagnostic tests available to detect the infection. Due to the increase in incidence of ZIKV infections, there is an immediate need to develop new diagnostic tools and novel preventive as well as therapeutic modalities based on understanding the molecular mechanisms underlying the disease.

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Hearing loss in congenital Zika virus

Cited by 3 publications

References 3 publications

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Congenital Cytomegalovirus-Related Hearing Loss

Zika Virus: An Emerging Global Health Threat

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