The potential role of amlodipine on experimentally induced bacterial rhinosinusitis

Tatar, Arzu; Korkmaz, Mukadder; Yayla, Muhammed; Polat, Elif; Uslu, Hakan; Halıcı, Zekai; Parlak, Seçil Nazife

doi:10.1016/j.bjorl.2016.08.006

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…It has been described that some calcium channel blockers exhibit quite low in vitro antibacterial activities in the absence of antibiotics with MICs ranging from 10 to 200 mg/L [151][152][153][154][155][156][157] (Table 2). Verapamil was tested against M. tuberculosis and M. abscessus only and was inactive [156,157].…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

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Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Dalhoff

2020

Infection

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Purpose Advances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the analysis of the ancestry of pro- and eukaryotic genes and proteins. Methods This review summarizes findings of structural and/or functional homologies of pro- and eukaryotic enzymes catalysing analogous biological reactions because of their highly conserved active centres so that non-antibiotics interacted with bacterial targets. Results Protease inhibitors such as staurosporine or camostat inhibited bacterial serine/threonine or serine/tyrosine protein kinases, serine/threonine phosphatases, and serine/threonine kinases, to which penicillin-binding-proteins are linked, so that these drugs synergized with β-lactams, reverted aminoglycoside-resistance and attenuated bacterial virulence. Calcium antagonists such as nitrendipine or verapamil blocked not only prokaryotic ion channels but interacted with negatively charged bacterial cell membranes thus disrupting membrane energetics and inducing membrane stress response resulting in inhibition of P-glycoprotein such as bacterial pumps thus improving anti-mycobacterial activities of rifampicin, tetracycline, fluoroquinolones, bedaquilin and imipenem-activity against Acinetobacter spp. Ciclosporine and tacrolimus attenuated bacterial virulence. ACE-inhibitors like captopril interacted with metallo-β-lactamases thus reverting carbapenem-resistance; prokaryotic carbonic anhydrases were inhibited as well resulting in growth impairment. In general, non-antibiotics exerted weak antibacterial activities on their own but synergized with antibiotics, and/or reverted resistance and/or attenuated virulence. Conclusions Data summarized in this review support the theory that prokaryotic proteins represent targets for non-antibiotics because of a common evolutionary origin of bacterial- and mammalian targets resulting in highly conserved active centres of both, pro- and eukaryotic proteins with which the non-antibiotics interact and exert antibacterial actions.

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Section: Calcium Channel Blockersmentioning

confidence: 99%

“…Amlodipine acted as a tissue protectant in experimentally induced S. aureus rhinosinusitis. Both, monotherapy with cefazolin or amlodipine reduced numbers of macrophages in epithelial cells by 57% and 39%, respectively [155].…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Dalhoff

2020

Infection

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“…Parameter 4 -Experimentally susceptible domestic species (or family/order) Many studies have experimentally applied (AMR) S. aureus or MRSA (of human origin) in common laboratory animals, typically to study its pathology or test new strategies for battling its infections: mice (Kim et al, 2014;Marra, 2020), guinea pigs (Baldoni et al, 2009;Tatar et al, 2017), rabbits (Casta ñeda et al, 2021;Long et al, 2021) and rats (Marra, 2020;Valente et al, 2021). Even Drosophila melanogaster models have repeatedly been deployed (Wu et al, 2012;Thomsen et al, 2016).…”

Section: Mammalsmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial‐resistant Staphylococcus aureus in cattle and horses

Nielsen¹,

Bicout²,

Calistri³

et al. 2022

EFS2

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Staphylococcus aureus ( S. aureus ) was identified among the most relevant antimicrobial‐resistant (AMR) bacteria in the EU for cattle and horses in previous scientific opinions. Thus, it has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its categorisation according to disease prevention and control rules as in Article 9, and Article 8 for listing animal species related to the bacterium. The assessment has been performed following a methodology previously published. The outcome is the median of the probability ranges provided by the experts, which indicates whether each criterion is fulfilled (lower bound ≥ 66%) or not (upper bound ≤ 33%), or whether there is uncertainty about fulfilment. Reasoning points are reported for criteria with uncertain outcome. According to the assessment here performed, it is uncertain whether AMR S. aureus can be considered eligible to be listed for Union intervention according to Article 5 of the AHL (60–90% probability). According to the criteria in Annex IV, for the purpose of categorisation related to the level of prevention and control as in Article 9 of the AHL, the AHAW Panel concluded that the bacterium does not meet the criteria in Sections 1, 2 and 4 (Categories A, B and D; 1–5%, 5–10% and 10–33% probability of meeting the criteria, respectively) and the AHAW Panel was uncertain whether it meets the criteria in Sections 3 and 5 (Categories C and E, 33–90% and 60–90% probability of meeting the criteria, respectively). The animal species to be listed for AMR S. aureus according to Article 8 criteria include mainly mammals, birds, reptiles and fish.

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“…The species studied include sheep (39)(40)(41)(42) , pigs (43) , rodents such as guinea pigs (44,45) , rats (46) and mice (47)(48)(49) as well as ferrets (50) and rabbits (33,51,52) . One study also examined the suitability of mink as an animal model for studying Pseudomonas aeruginosa sinusitis (53) .…”

Section: Current Animal Models For Inflammatory Mucosal Diseasesmentioning

confidence: 99%

Animal models for inflammatory mucosal disease and their potential for studying the microbiome in chronic rhinosinusitis

Lux¹,

Douglas²,

Cho³

et al. 2019

RHINOL

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Chronic rhinosinusitis (CRS) is a morbid condition of the paranasal sinuses which severely impairs patients' quality of life. CRS represents one of the leading diseases that are responsible for antibiotic prescriptions. However, there is little evidence to support the efficacy of antibiotics in CRS. Due to the highly heterogeneous nature of CRS determining the underlying etiology is challenging. The mucosal microbiome has been hypothesised to play a role in the pathophysiology of CRS.Several attempts to establish a representative model of CRS have been made to help determine the pathogenesis of this condition. This review summarises the current literature on model systems for inflammatory sinus disease. Fourteen different studies are discussed, including mouse, rabbit and sheep as model organisms. A detailed description of the methods for model development and examples for their application are provided. Focus is put on animal models that should be suitable for studying the sinonasal microbiome in CRS. To date, only two studies sought to employ their model for microbiome analysis. Other models are included for which there is currently no microbiome information, however they are of potential use in this regard and we thus discuss their suitability.This review identifies a need for further employment of animal models of CRS for microbiome research. Recently, a rabbit model of CRS featuring several qualities that make it particularly suitable for microbiological research has been described. This model system represents a further advance of translational research in the field of CRS.

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The potential role of amlodipine on experimentally induced bacterial rhinosinusitis

Abstract: The non-antibiotic compound amlodipine may have a role in acute rhinosinusitis treatment through tissue protective, antioxidant and anti-inflammatory mechanisms.

Cited by 3 publications

References 33 publications

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial‐resistant Staphylococcus aureus in cattle and horses

Animal models for inflammatory mucosal disease and their potential for studying the microbiome in chronic rhinosinusitis

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