Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Chen, Yanqiu; Zhou, Lifeng; Yang, Yan

doi:10.1016/j.bjorl.2016.03.006

Cited by 5 publications

(1 citation statement)

References 21 publications

(18 reference statements)

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“…In a previous study it was shown that circulating platelet activity, the measure of beta-TG, in patients with grass-pollen induced intermittent rhinitis during the course of the dose increase phase of grass pollen SIT did not show any significant changes (23,24). Besides, a recent study showed that platelet activation is inhibited significantly during sublingual immunotherapy (25). In our study, changes of MPV values and platelet counts could be explained by allergen exposure as it is applied in allergen immunotherapy.…”

Section: Discussionmentioning

confidence: 98%

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Vezir¹,

Civelek²,

Abul³

et al. 2018

Asthma Allergy Immunol

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Amaç: Trombositler hemostaz yanında inflamasyonun patogenezinde rol oynar. Ortalama trombosit hacmi (MPV) trombosit aktivasyonunun biyolojik belirteci olarak kullanılır. Allerjik hastalıkların patogenezinde trombositlerin rolünün iyi bilinmesine rağmen MPV değeri allerjik hastalıklarda halen tartışmalıdır. Çalışmanın amacı Allerjik hastalıkları olan hastalarda ve subkutan venom ve aeroallerjen immünoterapisi alan hastalarda MPV değerindeki değişiklikleri izlemektir. Gereç ve Yöntem: Pediatrik allerji ve immünoloji kliniğimiz tarafından izlenen hastalar çalışmaya alındı. Allerjik hastalıklar grubuna atopik dermatit, besin allerjisi, kronik ürtiker, allerjik rinit, astım ve obez astımlı hastalar dahil edildi. Kontrol grubuna yaş ve cinsiyet uygun sağlıklı kontroller alındı. Allerjik hastalıklar grubu MPV değerleri ve kontrol grubu MPV değerleri karşılaştırıldı. Subkutan immünoterapi grubuna venom ve aeroallerjen immünoterapisi yapılan hastalar alındı. İmmünoterapi öncesi ve immünoterapinin 2. yılındaki MPV değerleri karşılaştırıldı. Bulgular: Atopik dermatit grubunda 132, besin allerjisi grubunda 47, allerjik rinit grubunda 48, kronik ürtiker grubunda 102, astım grubunda 22, obez astım grubunda 31 hasta mevcuttu. MPV değeri hasta grupları ve kontrol grupları arasında istatistiksel olarak farklı değildi. Astımlı hastalarda obezite eşlik etmesi, atopik dermatitte şiddet skoru sınıflaması, kronik ürtikerde otoimmünite varlığı MPV değerinde istatistiksel anlamlı farklılık oluşturmadı.

show abstract

Section: Discussionmentioning

confidence: 98%

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Vezir¹,

Civelek²,

Abul³

et al. 2018

Asthma Allergy Immunol

View full text Add to dashboard Cite

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Specific sublingual immunotherapy in children with perennial rhinitis: a systemic review and meta‐analysis

Chen

Lei

Cai

et al. 2020

Int Forum Allergy Rhinol

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Background Allergic rhinitis (AR) is a major public health problem and is increasing worldwide. AR affects children's learning efficiency, sleep quality, and other major aspects of life. Sublingual immunotherapy (SLIT) is effective and safe for children with seasonal AR, but for children with perennial allergic rhinitis (PAR) caused by house dust mites (HDM), its effectiveness and safety is less convincing. Methods Medical literature databases up to 2019 were searched for published and unpublished pieces of evidence. Studies were individually screened by 2 reviewers against the eligibility criteria. Primary outcomes were total nasal symptoms scores (TNSS) and total medication scores (TMS). The secondary outcomes were total ocular symptoms scores and adverse events (AEs). Random effect models and fixed‐effect models were used to calculate the standard mean difference (SMD) and risk ratio (RR), respectively. Results We identified 3772 abstracts, of which only 16 studies met our established criteria. SLIT significantly reduced TNSS (SMD –1.73; 95% CI, –2.62 to –0.84; p = 0.0001) and TMS (SMD –1.21; 95% CI, –1.75 to –0.67; p < 0.00001). Compared with children taking placebo, children taking SLIT were 1.08 (95% CI, 1 to 1.17; p = 0.05), 1.15 (95% CI, 0.87 to 1.51; p = 0.32), and 1.68 (95% CI, 0.68 to 4.11; p = 0.26) times more likely to develop mild, moderate, and severe AEs, respectively. Conclusion HDM SLIT can effectively alleviate TNSS and TMS in children with PAR, but care should be taken to avoid harm due to possible adverse drug reactions.

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The efficacy of sublingual immunotherapy for allergic diseases in Asia

Liu

Wang

2018

Allergology International

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Sublingual immunotherapy (SLIT) has been proven to be safe and effective from an abundance of Western literature, but data from Asia is less complete. This review aims to examine the basic science, safety and efficacy of SLIT in Asian patients, and to determine future research needs in Asia. We performed a literature search on PUBMED, Scopus, and Cochrane Library database for articles on SLIT originating from Asian countries through Nov 2017. There were 18 randomized, double-blind, placebo-controlled trials, of which 9 involved solely paediatric subjects. Overall, sublingual immunotherapy is safe and is efficacious in Asian populations in allergic rhinitis (AR) and asthma. House dust-mite SLIT is effective in both mono- and polysensitized AR patients. Efficacy of SLIT is comparable to subcutaneous immunotherapy. Data on long term efficacy is lacking. A disproportionate majority of research originates from China and Japan, reflecting an asymmetry of access to SLIT within Asia. Significant disparities exist in the development of the allergy speciality, prescription patterns of SLIT, and pharmacological potencies of different SLIT products within and between Asian nations. We conclude that current available evidence suggests SLIT is efficacious in Asians but data quality of evidence is hampered by non-placebo controlled studies with methodological limitations. More data is needed in South and Southeast Asian populations. Future efforts may be directed towards improving access to SLIT in developing countries, standardization of SLIT dosage, and evaluating long term clinical outcomes.

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Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Cited by 5 publications

References 21 publications

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Specific sublingual immunotherapy in children with perennial rhinitis: a systemic review and meta‐analysis

The efficacy of sublingual immunotherapy for allergic diseases in Asia

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