Study of cochlear microphonic potentials in auditory neuropathy

Soares, Ilka do Amaral; Menezes, Pedro de Lemos; Carnaúba, Aline Tenório Lins; Andrade, Kelly Cristina Lira de; Lins, Otávio Gomes

doi:10.1016/j.bjorl.2015.11.022

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…The higher the stimulation intensity, the greater the displacement of the basement membrane and the corresponding increase in CM activity. 21,22 The classifying audiometric configurations of OAE absent group was mostly flat type, while the OAE present group was mostly rising type. 23 In terms of the grades of pure-tone hearing loss, which was predominantly severe or profound, and the average threshold was around 95 dB HL in both groups.…”

Section: Discussionmentioning

confidence: 95%

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The audiological characteristics of infant auditory neuropathy patients without otoacoustic emission

Lan

Shi

et al. 2022

Laryngoscope Investig Oto

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Objective: To explore the audiological characteristics of infant auditory neuropathy (AN) patients with cochlear microphonic (CM) recorded but absent otoacoustic emission (OAE), clinically reducing the rate of missed diagnosis of AN. Methods:We retrospectively analyzed the audiological characteristics of infant AN patients in our medical center between 2003 and 2020. A total of 18 infant AN patients were OAE absent group, with CM present and distortion product otoacoustic emission (DPOAE) absent in both ears. A total of 44 infant AN patients were OAE present group, with CM and DPOAE present in both ears.Results: (1) The found age in OAE absent group was 0.9 (0.02) years old, which was younger than 1.11 (1.63) years old in OAE present group (p = .041). (2) The CM threshold of OAE absent group was 80 (10) dB nHL, which was significantly higher (p < .001) than OAE present group. CM amplitude were smaller (p < .05), and CM duration were shorter (p < .05) in OAE absent group. (3) The thresholds of auditory steady-state response (ASSR) at 0.5, 1, 2, and 4 kHz were 94 (10), 94 (10), 87 (20), and 81 (10) dB HL cg, respectively in OAE absent group, which were higher than those in OAE present group (p < .01).Conclusions: Infant AN patients with CM present and OAE absent showed earlier detection and different audiological performance, which was manifested in ASSR thresholds, audiometric configurations and CM performance. CM thresholds were increased, amplitude and duration were decreased, non-linearity of I/O function was reduced.

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Section: Discussionmentioning

confidence: 95%

“…CM amplitude directly reflects the stimulus amplitude. The higher the stimulation intensity, the greater the displacement of the basement membrane and the corresponding increase in CM activity 21,22 …”

Section: Discussionmentioning

confidence: 99%

The audiological characteristics of infant auditory neuropathy patients without otoacoustic emission

Lan

Shi

et al. 2022

Laryngoscope Investig Oto

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“…It can be recorded in people who are infected. Different interpratations can be made for this lack of matching results, including the possibility of partial involvement of the middle ear and consequently [18], the absence of recording of otoacoustic emissions or significant damage hair cells [2].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with AN/AD, the function of the external hair cells of the cochlea is normal, while the neural conduction at the level of the vestibulo-cochlear is damaged. In this regard, the responses of otoacoustic emissions (OAE) are normal and there is abnormality in brainstem response [1][2][3]. For this reason, children and infants with this neurological disorder are not detected using OAE.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Causes of Auditory Neuropathy/Dys-synchrony (AN/AD) in Children with Hearing Impairment

Gohari

Emami

Mirbagheri

et al. 2018

Indian J Otolaryngol Head Neck Surg

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There are a wide variety of hearing impairments that part of it is auditory neuropathy/dys-synchrony (AN/ AD). So, the object of this study was determination the prevalence and causes of AN/AD in children with hearing impairment. This study was a descriptive cross-sectional survey. The sample size consisted of 105 hearing impairment children. All them were under hearing screening tests (tympanometry), distortion and transient evoked otoacoustic emissions (DPOAEs ? TEOAE) and automated auditory brainstem response (AABR). If they were suspected to AN/AD, for complete diagnostic measurements were referred to our hospital. Four cases (8 ears) with AN/ AD were diagnosed, which had an average age 37 months (SD = 8.67). So, the prevalence of AN/AD was 3.8 % among hearing impaired children. The findings of this study showed that there are the relationships between AN/ AD and fluctuating hearing loss, acoustic reflex, high bilirubin, blood exchange after birth, neonatal intensive (NICU) care unit (P \ 0.05). The simultaneous use of both ABR and OAE tests in the birth screening provide much more useful information than when each of these tests is used alone.

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“…For SHL, hair cells in the cochlear high frequency region are more easily involved, often showing a descending hearing. 6 SHL based on low frequency hearing loss can also be seen in the early Meniere’s disease. Due to loudness recruitment, stapes muscle reflex can often be induced, the low frequency amplitude of distortion product otoacoustic emission is decreased, auditory brainstem response wave I and action potential can be induced, and patients have a typical triple sign, i.e.…”

Section: Discussionmentioning

confidence: 99%

Clinical relationship between auditory neuropathy and nervous system diseases

et al. 2017

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Objective:To explore the clinical relationship between auditory neuropathy (AN) and nervous system diseases.Methods:A total of 134 AN patients who were treated in our hospital from December 2011 to April 2016 were selected. Then 120 cases (240 ears) with complete data of pure tone audiometry and acoustic immittance test were selected as an AN1 group, which was compared with 30 patients (49 ears) with general sensorineural hearing loss (SHL) in regard to the results of pure tone audiometry and acoustic immittance test. On the other hand, 79 cases (158 ears) of the 134 patients with complete data of DP otoacoustic emission test were selected as an AN2 group, which was compared with 30 normal subjects (60 ears) regarding the results of DP otoacoustic emission test.Results:Increases in the pure-tone hearing threshold by air conduction of AN1 group significantly exceeded those of SHL group at 0.125 and 0.25 kHz (low frequency) (P<0.05). The former group had significantly lower values at 1.0, 2.0 kHz (moderate frequency) and 4.0, 8.0 kHz (high frequency) (P<0.05). Of 134 patients, 14 (19 ears) had evoked V wave upon auditory brainstem response, whereas no waves after I wave were evoked in other tested ears. Distortion product (DP) otoacoustic emissions could all be evoked. AN2 group had significantly higher amplitudes of DP-gram than those of normal control group at 0.5 and 0.7 kHz (low frequency) (P<0.05). Except for three cases of unsteady walking and 10 of dizziness, others did not suffer from typical symptoms of vertigo attack. As to caloric test-induced electronystagmograms, there were 30 bilaterally normal cases (75.0%), one case of left-side semicircular canal paresis (25%) and nine cases of bilateral semicircular canal paresis (22.5%). Four patients with other nervous system diseases were complicated with AN. Other nervous system disorders included three cases of optic nerve atrophy and 7 of lower limb nerve damage.Conclusion:According to characteristic hearing dysfunction, AN may occur in the afferent pathway of acoustic nerve, probably accompanied by the pathological changes of efferent nerve in the olivocochlear system inside the brainstem.

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Study of cochlear microphonic potentials in auditory neuropathy

Cited by 11 publications

References 25 publications

The audiological characteristics of infant auditory neuropathy patients without otoacoustic emission

The audiological characteristics of infant auditory neuropathy patients without otoacoustic emission

The Prevalence and Causes of Auditory Neuropathy/Dys-synchrony (AN/AD) in Children with Hearing Impairment

Clinical relationship between auditory neuropathy and nervous system diseases

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