The facial palsy as first symptom of the temporal bone lung cancer metastasis

Djerić, D; Boričić, Ivan; Tomanović, Nada; Čvorović, Ljiljana; Blažić, Srbislav; Folić, Miljan; Djorić, Igor

doi:10.1016/j.bjorl.2015.09.007

Cited by 4 publications

(4 citation statements)

References 7 publications

(13 reference statements)

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“…Of those, 2,308 were excluded from review, and the remaining 576 full‐text articles were scrutinized for eligibility. After excluding 467 articles, a total of 109 articles published from 1948 to 2019 remained in the final analysis 4–6,9–11,14–116 . This provided a total of 255 individual cases for data extraction.…”

Section: Resultsmentioning

confidence: 99%

Metastatic Disease of the Temporal Bone: A Contemporary Review

et al. 2020

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Objectives To identify the frequency and primary site of metastatic pathologies to the temporal bone and characterize the associated symptomatology. Methods The MEDLINE, Embase, and Web of Science databases were systematically reviewed according to the PRISMA guidelines to identify all cases of pathologically confirmed distant temporal bone metastases published with English translation until October 2019. Descriptive statistics were performed. Results Out of 576 full‐length articles included for review, 109 met final criteria for data extraction providing 255 individual cases of distant temporal bone metastases. There was a male predominance (54.9%) with median age of 59.0 years (range 2–90). The most common locations of primary malignancy included the breasts (19.6%), lungs (16.1%), and prostate (8.6%). Most tumors were carcinomas of epithelial origin (75.3%) and predominantly adenocarcinoma (49.4%). The commonest metastatic sites encountered within the temporal bone were the petrous (72.0%) and mastoid (49.0%) portions. Bilateral temporal bone metastases occurred in 39.8% of patients. Patients were asymptomatic in 32.0% of cases. Symptomatic patients primarily reported hearing loss (44.3%), facial palsy (31.2%), and otalgia (16.6%) for a median duration of 1 month. Petrous lesions were associated with asymptomatic cases (P = .001) while mastoid lesions more often exhibited facial palsy (P = .026), otalgia (P < .001), and otorrhea (P < .001). Non‐carcinomatous tumors were associated with petrosal metastasis (P = .025) and asymptomatic cases (P = .109). Carcinomatous metastases more often presented with otalgia (P = .003). Conclusions Temporal bone metastasis is uncommon but should be considered in patients with subacute otologic symptoms or facial palsy and history of distant malignancy. Laryngoscope, 131:1101–1109, 2021

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Section: Resultsmentioning

confidence: 99%

Metastatic Disease of the Temporal Bone: A Contemporary Review

et al. 2020

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“…In the current case, however, the tumor showed diffuse invasive growth, and the patient had "mass effect" and neurological dysfunction. If the tumor involves the skull base, most cranial nerves can be involved, resulting in paralysis [4][5][6][7][8][9][10] . Tumors of the middle and posterior fossa involve more nerves, and patients can show different syndromes, such as acute cavernous sinus syndrome, Garxin syndrome, and occipital condylar syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with skull metastasis of lung cancer have a very poor prognosis, especially when the tumor invades the skull base and cannot be removed by surgery. Even different radiotherapy and chemotherapy schemes may not result in an ideal response, and patients often die within months of their diagnosis, or are at risk of sudden death [5] . The current patient initially refused surgical treatment because of the surgical risk.…”

Section: Discussionmentioning

confidence: 99%

Calvarial Metastasis of Lung Cancer: a Case Report and Literature Review

Xing¹,

Wang²,

Guo³

et al. 2021

Preprint

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Background: The skull is an uncommon site for bone metastasis of lung cancer. The most common type of skull metastasis is calvarial circumscribed intraosseous lesions. However, the use of targeted therapy or surgery remains controversial and the prognosis is poor.Case presentation: Skull metastasis was detected in a woman 4 years after resection of non-small cell lung cancer. Despite targeted drug therapy, the tumor continued to grow. However, the patient refused surgical treatment until she developed neurological deficit. An epidural effusion occurred after the operation. The patient was followed up for 16 months and her condition remained stable.Conclusion: Skull metastases of lung cancer can grow invasively. The current and previously reported cases highlight the importance of prompt removal of tumors located in the calvaria.

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“…Meanwhile, omission of congenital abnormalities, systemic inflammation or infection, or trauma as a prime cause of facial palsy should raise a suspicion of metastatic tumors to the temporal bone, as well as primary malignancies. Temporal bone metastasis is a rare clinical event and imposes a diagnostic challenge due to its asymptomatic feature in most cases [4]. The mounting clinical report displays the involvement of temporal bone metastasis as the cause of facial nerve palsy [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Isolated Facial Nerve Palsy Due to Temporal Bone Metastasis

Isaac

Pasha

Yap³

et al. 2022

Cureus

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Isolated facial nerve palsy resulting from temporal bone metastasis is rare and has been sparsely reported in the literature to be the initial presentation of cancer. The most commonly reported sites of origin of such metastases include the breast, lung, kidney, gastrointestinal tract, larynx, prostate, and thyroid, to name a few. Here, we discuss a patient initially presenting with isolated lower motor neuron facial nerve palsy. The diagnosis was revised to that of breast cancer with metastasis to the temporal bone resulting in facial nerve paralysis following the subsequent clinical presentation.

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The facial palsy as first symptom of the temporal bone lung cancer metastasis

Cited by 4 publications

References 7 publications

Metastatic Disease of the Temporal Bone: A Contemporary Review

Metastatic Disease of the Temporal Bone: A Contemporary Review

Calvarial Metastasis of Lung Cancer: a Case Report and Literature Review

Isolated Facial Nerve Palsy Due to Temporal Bone Metastasis

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