Primary laryngeal aspergillosis in the immunocompetent state: a clinical update

Dutta, Mainak; Jotdar, Arijit; Kundu, Sohag; Ghosh, Bhaskar; Mukhopadhyay, Subrata

doi:10.1016/j.bjorl.2015.06.002

Cited by 15 publications

(12 citation statements)

References 6 publications

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“…Globally, only 38 cases have been documented over the last five decades [2]. Patients commonly present with sore throat, hoarseness of voice, cough, and odynophagia [3], and our patient had progressive vocal fatigue. The pathogenesis of laryngeal aspergillosis is not well understood but is most likely multifactorial.…”

Section: Discussionmentioning

confidence: 89%

Pulmonary tuberculosis in an immunocompetent patient with primary laryngeal aspergillosis

Sarkar¹,

Gope

2020

Respirology Case Reports

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Primary laryngeal aspergillosis in an immunocompetent host is a rare entity. On the other hand, pulmonary tuberculosis (PTB) among healthcare workers in a tuberculosis endemic zone with high risk of exposure is not uncommon but may be underdiagnosed especially when masquerading as another disease. In this report, we are presenting a 45-year-old physician who presented with chronic dry cough, hoarseness of voice, and progressive vocal fatigue. Fibreoptic laryngoscopy (FOL) showed whitish patches on both vocal folds and he was initially diagnosed with laryngeal aspergillosis following histopathological examination. As there was no significant improvement on antifungal treatment, we re-evaluated the case and, on further investigation, concomitant PTB was detected. Patient responded to category-I anti-tubercular drugs with complete recovery.

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Section: Discussionmentioning

confidence: 89%

Pulmonary tuberculosis in an immunocompetent patient with primary laryngeal aspergillosis

Sarkar¹,

Gope

2020

Respirology Case Reports

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“…The pathogenesis of laryngeal aspergillosis in an immunocompetent host is not well understood. The Aspergillus conidia are ubiquitous in nature as the fungus grows in a saprophytic environment (soil and decaying matter), it could well be possible that exposure of heavy fungal load in air may allow the fungus colonise the dark airway cavities [ 3 ] which could favour their slow germination without any symptoms. Such colonisation of the paranasal sinuses leads to fungal ball formation [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Age group ranged from 12 to 74 years. Dutta M et al [ 3 ] reported in 2015 that 50% of immunocompetent subjects with primary laryngeal aspergillosis had no identifiable contributory factors, but 14.29% had vocal abuse and steroid intake. Smoking, broad-spectrum antibiotics and exposure to radiation was detected in 10.7% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…It often mimics the pre-malignant and malignant conditions (squamous cell carcinoma) of larynx. Fungal laryngitis is usually characterized by sore throat, earache, hoarseness of voice, cough, odynophagia, formation of endolaryngeal and perilaryngeal white plaques, granulation tissue, ulcerations, erythema and edema [ 3 ]. Diagnosis and prompt treatment are essential to prevent complications like scarring of the vocal folds, compromised airway due to glottic edema and dissemination of the pathogen.…”

Section: Introductionmentioning

confidence: 99%

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Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update

et al. 2018

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BackgroundLaryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. Primary laryngeal aspergillosis in immunocompetent individuals is extremely rare, with a few cases documented over the last five decades.Case presentationWe report a case of primary localised laryngeal aspergillosis in a 21-year-old apparently immunocompetent student. Septate hyphae were observed on histopathology of the laryngeal lesion, which was further confirmed as Aspergillus fumigatus after extraction of fungal DNA from formalin fixed paraffin embedded tissue (FFPET) and sequencing. The patient responded well to oral itraconazole therapy over a month.ConclusionsSince last few decades, cases of primary laryngeal aspergillosis in immunocompetent individuals are on the rise, globally. This is the first case of invasive laryngeal aspergillosis reported in Nepal. The extraction of DNA from tissue and sequencing helps to identify the etiological agent, when culture fails to isolate the fungus.

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“…This is the first report of primary laryngeal aspergillosis in a SOT recipient. After an extensive review of the literature, we found other 35 cases of primary laryngeal aspergillosis that have been published in patients with different immune states . We summarize relevant features in Table .…”

Section: Introductionmentioning

confidence: 99%

Aspergillus infection of the larynx in a solid organ transplant recipient

Wisniowski-Yáñez

Ramírez-Anguiano

Rosado-Canto

et al. 2018

Transplant Infectious Dis

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Primary laryngeal aspergillosis is a rare condition. Only a few cases have been reported in the past years. Most of them have been reported in healthy patients or with a mild immunocompromised state. We report a case of primary laryngeal aspergillosis in a solid organ transplant recipient (SOT), an infection not previously described in this population; we reviewed the published literature in all populations.

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Primary laryngeal aspergillosis in the immunocompetent state: a clinical update

Cited by 15 publications

References 6 publications

Pulmonary tuberculosis in an immunocompetent patient with primary laryngeal aspergillosis

Pulmonary tuberculosis in an immunocompetent patient with primary laryngeal aspergillosis

Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update

Aspergillus infection of the larynx in a solid organ transplant recipient

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