Oral manifestations in AIDS

Hirata, Cleonice Hitomi Watashi

doi:10.1016/j.bjorl.2014.12.001

Cited by 14 publications

(24 citation statements)

References 3 publications

(2 reference statements)

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“…36 The prevalence of xerostomia among HIV-infected patients, has been estimated to range from 1.2 to 40% 22 and reduced salivary flow rate occurs in 2-30% of subjects. 37 The findings of the research reported here indicated that 68.2% of the subjects whose saliva contained HCMV positive had xerostomia, while 54.5% of the subjects experienced a low unstimulated salivary flow rate (0.1-0.2 ml/min). Statistical analysis confirmed a significant relationship between the presence of HCMV in saliva and xerostomia.…”

Section: Discussionmentioning

confidence: 52%

“…43,44 A number of investigators have also reported that oral manifestation of HCMV correlates with the severity of immunosuppression in AIDS patients with CD4 counts below 100 cells/mm3 in the disseminated form of the disease. 37 This indicates that HCMV reactivation in HIV-infected patients may occur under advanced immunosuppressive conditions.…”

Section: Discussionmentioning

confidence: 99%

“…44 Furthermore, antiretroviral drugs (including nucleoside transcriptase inhibitors and protease inhibitors) may also cause xerostomia or hyposalivation. 37 However, the exact mechanism by which this ART can lead to salivary disfunction remains unclear. The suggested mechanism may be due to alteration of the structure and composition of saliva due to the chemical structure of antiretroviral drugs leading to a reduced salivary flow rate.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate

Sufiawati¹,

Suniti²,

Nelonda³

et al. 2019

Dent. J.

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Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox’s questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p<0.05), but not with gB-1. There was no significant relationship between xerostomia and SFR rates in the research subjects with HCMV positive saliva (p> 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate

Sufiawati¹,

Suniti²,

Nelonda³

et al. 2019

Dent. J.

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“…O grupo III abrange lesões como por exemplo a osteomielite 11 . Estas lesões não são únicas para portadores do HIV, mas o aparecimento de algumas lesões bucais são fortemente sugestivas de comprometimento da resposta imune, por isso o aparecimento nesses pacientes 12 . Estas podem ser fúngicas, bacterianas e virais, além de processos neoplásicos e lesões de natureza desconhecida 9 .…”

Section: Resultsunclassified

“…A maior parte desses tratamentos não cura, mas reduz o tamanho e o número. Estudos recentes mostram alguma eficácia com agentes anti-angiogenesis, tais como talidomida e ácido retinóico 12 .…”

Section: Lesões Neoplásicas 41 Sarcoma De Kaposiunclassified

Manifestações bucais de pacientes soropositivos para HIV/AIDS

Paulique¹,

Cruz²,

Simonato³

et al. 2017

Arch Health Invest

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ResumoIntrodução: As lesões bucais ocorrem com frequência em pacientes infectados pelo vírus HIV, podendo ser a representação dos primeiros sinais da doença, o que torna importante o diagnóstico inicial precoce pelos cirurgiões-dentistas. Objetivo: Apresentar uma síntese das informações mais relevantes sobre as principais manifestações bucais em pacientes soropositivos para HIV/AIDS. Material e Método: Foi realizada uma revisão da literatura em livros e bases de dados eletrônicos. Resultados: Os pacientes soropositivos podem desenvolver várias lesões bucais e peribucais, que não são únicas para portadores do HIV, mas ocorrem em maior frequência quando associadas a imunossupressão. As mais prevalentes são Infecções

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