Allergic fungal sinusitis eroding the pterygoid plates: a rare case series

Marglani, Osama; Shaikh, Ahmed

doi:10.1016/j.bjorl.2014.05.028

Cited by 6 publications

(14 citation statements)

References 8 publications

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“…[27] To the best of our knowledge, this is the first case of fungus ball owing to G. candidum reported in Iran. A. flavus was the most common species in the present study, whereas Marglani and Shaikh[9] reported Aspergillus terreus and Aspergillus fumigatus as the etiologic agent of AFS by phenotypic methods. Cavanna et al .…”

Section: Discussionmentioning

confidence: 55%

“…Noninvasive types contain AFS and fungus ball. [9] AFS is pathologically and clinically a specific form of rhinosinusitis in atopic immunocompetent people. It is most frequent among young individuals; the mean age of occurrence is about 21 years, whereas the mean age of patients in the present study was 46 years.…”

Section: Discussionmentioning

confidence: 99%

“…[67] A variety of fungal agents such as yeasts, dematiaceous fungi, and hyaline fungi have been involved in fungal sinusitis. [89] The aim of the present study is to identify the etiologic agents of fungal sinusitis isolated from AFS and fungus ball using molecular methods.…”

Section: Introductionmentioning

confidence: 99%

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An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

et al. 2017

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Background:Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus. Fungal sinusitis caused by various fungi such as Aspergillus species, Penicillium, Mucor, Rhizopus, and phaeohyphomycetes. The aim of the present study is to identify fungal species isolated from noninvasive fungal sinusitis by molecular methods.Materials and Methods:During 2015–2016, a total of 100 suspected patients were examined for fungal sinusitis. Functional endoscopic sinus surgery was performed using the Messerklinger technique. Clinical samples were identified by phenotypic and molecular methods. Polymerase chain reaction (PCR) sequencing of ITS1-5.8S-ITS2 region and PCR-restriction fragment length polymorphism with MspI restriction enzyme was performed for molecular identification of molds and yeasts, respectively.Results:Twenty-seven out of 100 suspected cases (27%) had fungal sinusitis. Nasal congestion (59%) and headache (19%) were the most common clinical signs among patients. Fifteen patients (55.5%) were male and 12 patients (44.5%) were female. Aspergillus flavus was the most prevalent fungal species (26%), followed by Penicillium chrysogenum (18.5%) and Candida glabrata species complex (15%).Conclusion:Since clinical manifestations, computed tomography scan, endoscopy, and histopathological findings are very nonspecific in AFS and fungus ball; therefore, molecular investigations are compulsory for precise identification of etiologic agents and appropriate management of these fungal infections.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

et al. 2017

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“…Paranasal fungal sinusitis infections are seen in two different forms as invasive and non-invasive. Invasive fungal sinusitis is observed in patients with impaired immune resistance and diabetes, whereas non-invasive form is observed in patients with normal immune resistance as allergic fungal sinusitis and myceloma (fungus ball) [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The diagnostic criteria for allergic fungal sinusitis which form non-invasive fungal sinusitis were first described and published by Millar in 1981. The diagnosis of mycetoma can be made easily by nasal examination, imaging, and histopathological methods [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Frequency of non-invasive fungal sinusitis in patients undergoing surgery for chronic rhinosinusitis

Gümüşsoy¹

2019

Int Med

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Background: In this study, we investigated the presence of non-invasive fungal sinusitis in patients who underwent endoscopic sinus surgery with the diagnosis of chronic rhinosinusitis in our clinic. Methods: A total of 283 patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis in our clinic between 2008-2018, who were at the ages of 18 or above, and who did not have invasive fungal sinusitis and tumor were included in the study. Sinus pathology was examined by routine examination using nasal endoscopy and computed tomography. Eosinophil count, total, and specific IgE levels were measured in the peripheral blood samples of the patients. Sinus surgery was performed under general and local anesthesia with the Messerklinger technique. Aspirated secretions from the sinuses and removed surgical tissues were examined microbiologically and histopathologically. Results: 68 females, 215 males, totally 283 patients with a mean age of 41 had sinus surgery; 11 (40.74%) females and 16 (59.26%) males, totally 27 (9.54%) patients had non-invasive fungal sinusitis. 18 (6.36%) of the cases were microbiologically reported as allergic fungal sinusitis while 9 (3.18%) of them reported as mycetoma. Nasal obstruction (19, 70.37%) and headache (13, 48.14%) were the most common clinical findings. Eosinophilic mucus was detected in the sinus material of the patients with allergic fungal sinusitis. According to their prevalence, Aspergillus, Penicillium, and Candida were the most prevalent in the patients with allergic fungal sinusitis, respectively; Aspergillus fumigatus and Aspergillus flavus were the most prevalent in the patients with allergic fungal sinusitis, respectively. Radiologically, fungal balls localized at the maxillary sinuses in six patients, the sphenoid sinuses in two patients, and the ethmoid sinus in one patient. As a treatment, sinus surgery was performed as a complete evacuation of the mucus and removal of pathological and polypoid tissues. The follow-up periods of the patients ranged between 7-31 months; the mean duration of follow-ups was 17 months. Non-invasive fungal infections were not treated with antifungal therapy, no recurrence was observed. Conclusions: In this study, non-invasive fungal sinus infection was detected 9.54% of patients. Nasal examination, radiological, and immunological examination should be applied to patients as additional examinations on the suspicion of pre-operative fungal rhinosinusitis; samples should be taken from the sinuses during surgery and should be examined for fungus microbiologically and histopathologically. Antifungal therapy was not administered to patients with non-invasive fungal infection. Endoscopic sinus surgery is a successful method in the treatment of non-invasive fungal rhinosinusitis.

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Clinical and radiological evaluation of maxillofacial and otorhinolaryngological manifestations of Hansen’s disease

Santo

Serafim

Loureiro

et al. 2022

Sci Rep

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To characterize maxillofacial, otorhinolaryngological and oral manifestations of Hansen’s disease (HD), we conducted a cross-sectional study in 21 current patients attending the Unidade Básica de Saúde de Jardim América, Espírito Santo, Brazil and 16 former patients resident at Pedro Fontes Hospital using data from computed tomography imaging, rhinoscopy, and oroscopy. Maxillofacial characteristics were compared with 37 controls. Differences in bone alterations across the three groups were determined mainly by severe resorption/atrophy being more frequent in former HD patients, with severe resorption/atrophy of the anterior alveolar process of maxilla in 50.0% (8/16) of former patients, 28.6% (6/21) of current patients and 10.8% (4/37) of controls and of nasal bones and aperture in 31.3% (5/16) of former patients compared with 0/21 current patients and two controls. There were no substantial differences in otorhinolaryngological and oroscopic findings between the two patient groups. HD patients had more tooth loss than the age-matched control group. Maxillofacial, otorhinolaryngological and oroscopic finding scores were strongly correlated only in current HD patients. Correlation between otorhinolaryngological and maxillofacial scores suggests that protocols for HD patient assessment and follow-up could include otorhinolaryngological evaluation, with radiological imaging where necessary, subject to replication of our findings in a larger study.

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Allergic fungal sinusitis eroding the pterygoid plates: a rare case series

Cited by 6 publications

References 8 publications

An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

An investigation on non-invasive fungal sinusitis; Molecular identification of etiologic agents

Frequency of non-invasive fungal sinusitis in patients undergoing surgery for chronic rhinosinusitis

Clinical and radiological evaluation of maxillofacial and otorhinolaryngological manifestations of Hansen’s disease

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