Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children's Hospital

Lyu, Shuang; Shi, Wei; Dong, Fang; Xu, Bao Ping; Liu, Gang; Wang, Quan; Yao, Kai Hu; Yang, Yong Hong

doi:10.1016/j.bjid.2024.103734

The Brazilian Journal of Infectious Diseases

2024

DOI: 10.1016/j.bjid.2024.103734

|View full text |Cite

Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children's Hospital

Shuang Lyu,

Wei Shi,

Fang Dong

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Estimation of in Vivo Performance of Sulfamethoxazole and Trimethoprim From Oral Suspensions Using in Vitro Release Data From a Mini Paddle Apparatus

RUIZ-SEGURA,

RIOS-RODRÍGUEZ,

REYES-RAMÍREZ

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

Objective: To estimate plasma concentrations-time profiles of sulfamethoxazole (SMZ) and trimethoprim (TMP) from oral pediatric suspensions through in vitro data generated with a mini paddle apparatus and dissolution media of physiological relevance. Post-marketing evaluation of pediatric formulations is always necessary. Methods: Dissolution profiles of SMZ/TMP were obtained with a mini paddle apparatus at 100 rpm and 200 ml of 0.1 N HCl (pH 1.2), pH 4.5 acetate buffer, and pH 6.8 phosphate buffer. The reference and three multi-source pediatric formulations were tested. Drugs were quantified by a UV derivative method. Dissolution profiles were compared with model-independent and model-dependent methods. Plasma levels were estimated with dissolution data and published in vivo information. Percent of prediction error (%PE) for Cmax and AUC0-inf at each condition was calculated. Results: In all conditions, similar dissolution profiles were found excepting for TMP of C drug product at pH 1.2 (f2<50). With model-independent comparisons significant differences in in vitro release performance of SMZ and TMP from all multi-source formulations were found (*P<0.05). When comparing the hypothetical Cmax and AUC0-inf of both drugs with in vivo data PE<15% were found only with reference and one formulation at pH 1.2. Conclusion: The mini paddle apparatus and dissolution media of pH 1.2 were the best conditions to estimate in vivo plasma concentrations of SMZ and TMP from reference. These settings seem adequate to evaluate in vitro performance of multi-source formulations. It is necessary to carried out human studies with the used fixed-dose combination formulations to correlate in vitro/in vivo data.

show abstract

Estimation of in Vivo Performance of Sulfamethoxazole and Trimethoprim From Oral Suspensions Using in Vitro Release Data From a Mini Paddle Apparatus

RUIZ-SEGURA,

RIOS-RODRÍGUEZ,

REYES-RAMÍREZ

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children's Hospital

Cited by 1 publication

References 34 publications

Estimation of in Vivo Performance of Sulfamethoxazole and Trimethoprim From Oral Suspensions Using in Vitro Release Data From a Mini Paddle Apparatus

Estimation of in Vivo Performance of Sulfamethoxazole and Trimethoprim From Oral Suspensions Using in Vitro Release Data From a Mini Paddle Apparatus

Contact Info

Product

Resources

About