Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon

da Silva, Marcos Eduardo Passos; Gomes, Maicon Aleandro da Silva; Rodrigues, Renata Santos; Lima, Nucia Cristiane da Silva; Carvalho, Anjo Gabriel; Taborda, Roger Lafontaine Mesquita; Matos, Najla Benevides

doi:10.1016/j.bjid.2023.103687

Cited by 4 publications

(9 citation statements)

References 29 publications

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“…Although the increase in resistance in A. baumannii was not as high as that in E. coli and K. pneumoniae , this bacterium already has intrinsic resistance to ertapenem and a high rate of resistance to meropenem and imipenem, as demonstrated by studies in Rondônia where the resistance to carbapenem was 76.2% 11 , 4.91% higher than what we found in our study; IC1 was the most frequent clonal group, followed by IC5 and IC4 12 . Furthermore, the greatest ARG plasticity was detected in A. baumannii , which presented with bla KPC -like or bla NDM -like together with bla OXA23 -like and bla OXA58 -like or even bla OXA23 -like together with bla OXA143 -like.…”

Section: Discussioncontrasting

confidence: 54%

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

dos Santos,

Cayô,

Valiatti

et al. 2024

Sci Rep

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Brazil is recognized for its biodiversity and the genetic variability of its organisms. This genetic variability becomes even more valuable when it is properly documented and accessible. Understanding bacterial diversity through molecular characterization is necessary as it can improve patient treatment, reduce the length of hospital stays and the selection of resistant bacteria, and generate data for health and epidemiological surveillance. In this sense, in this study, we aimed to understand the biodiversity and molecular epidemiology of carbapenem-resistant bacteria in clinical samples recovered in the state of Rondônia, located in the Southwest Amazon region. Retrospective data from the Central Public Health Laboratories (LACEN/RO) between 2018 and 2021 were analysed using the Laboratory Environment Manager Platform (GAL). Seventy-two species with carbapenem resistance profiles were identified, of which 25 species carried at least one gene encoding carbapenemases of classes A (blaKPC-like), B (blaNDM-like, blaSPM-like or blaVIM-like) and D (blaOXA-23-like, blaOXA-24-like, blaOXA-48-like, blaOXA-58-like or blaOXA-143-like), among which we will highlight Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Serratia marcescens, and Providencia spp. With these results, we hope to contribute to the field by providing epidemiological molecular data for state surveillance on bacterial resistance and assisting in public policy decision-making.

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Section: Discussioncontrasting

confidence: 54%

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

dos Santos,

Cayô,

Valiatti

et al. 2024

Sci Rep

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“…The pathogenicity of Acinetobacter is to cause infection when the body's resistance is reduced, which can cause respiratory and wound infections, and in severe cases can lead to death. It is often distributed in hospitals, water, and soil [40]. A strain of Brevundimonas vesicularis screened in this study is a rare opportunistic pathogen in humans.…”

Section: Discussionmentioning

confidence: 99%

Spatial Distribution and Seasonal Variation of Antibiotic-Resistant Bacteria in an Urban River in Northeast China

Xiao,

Wang,

et al. 2024

Water

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As the largest freshwater river flowing through Harbin, the Songhua River is a standby water source. It is very important to know the species and distribution of antibiotic-resistant bacteria (ARB) in the river. In this study, five antibiotics were selected to screen and identify ARB in spring and autumn. The results showed that the concentration of cefotaxime-resistant bacteria was the highest, and the maximum concentration at S6 in spring was up to 1.40 × 104 CFU/mL. In spring and autumn, bacteria resistant to three antibiotics were screened at S1 of the Songhua River, and bacteria resistant to five antibiotics were screened at S6. No multiple antibiotic-resistant bacteria (MARB) were screened in the other four sites in autumn, while MARB were screened in the other three samples except S2 in spring. In all sample areas in spring and autumn, the probability of screening MARB at S1 and S6 was the highest, reaching 100%. The identification results of 16S rDNA polymerase chain reaction (PCR) products of ARB showed that a total of 51 ARB strains from 15 bacterial genera were screened in the Songhua River, of which 20 ARB strains were from Pseudomonas. Among the 15 bacterial genera, bacteria from 8 bacterial genera have pathogenicity. The results of this study revealed the concentration, spatial distribution, and seasonal variation of culturable ARB in the Songhua River, providing data support for the remediation of antibiotic resistance gene (ARG) pollution in the river.

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“…Day-to-day life also involves risks caused by handling chemicals, body fluids and contact with infected people. [1][2][3][4][5][6][7][8][9][10][11][12][13] Therefore, when caring for patients and performing other duties, it is essential to use Personal Protective Equipment (PPE). Among the most commonly used in a hospital unit are [1][2][3][4][5][6][7][8][9][10][11][12][13]:…”

Section: Frequent Hand Washingmentioning

confidence: 99%

“…[1] It has been reported that the incidence of nosocomial infections in the intensive care unit (ICU) is around 2 to 5 times higher than in the general hospital population. [2] The increase in morbidity and mortality associated with nosocomial infections in the ICU is a matter of great current concern. Serious medico-legal issues also arise in this context, as the patient or their family sometimes blame the hospital staff for the infection and demand compensation.…”

Section: Introductionmentioning

confidence: 99%

Community-Acquired Infections Vs. Healthcare-Associated Infections-Hais as the Main Cause of Death in ICUS, Care and Procedures

Malaquias,

Paschoal,

da Costa

et al. 2024

Int. J. Res. Publ. Rev.

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Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon

Cited by 4 publications

References 29 publications

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

Spatial Distribution and Seasonal Variation of Antibiotic-Resistant Bacteria in an Urban River in Northeast China

Community-Acquired Infections Vs. Healthcare-Associated Infections-Hais as the Main Cause of Death in ICUS, Care and Procedures

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