Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)

Sabioni, Leticia R; Lorenzo, Andréa Rocha de; Castro‐Faria‐Neto, Hugo C.; Estato, Vanessa; Tibiriçá, Eduardo

doi:10.1016/j.bjid.2022.102719

Cited by 5 publications

(3 citation statements)

References 26 publications

(27 reference statements)

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“…The mechanism contributing to increased postoperative MACE in patients with preoperative COVID-19 remains a key knowledge gap and has important implications in identifying therapeutic strategies for reducing postoperative MACE. One of the primary mechanisms contributing to CVD following SARS-CoV-2 infection is endothelial dysfunction and vascular inflammation ( 31 , 32 ), and the stress of surgery is reported to have detrimental effects on the endothelium even among patients undergoing noncardiac surgeries ( 9 – 11 ). In fact, preoperative endothelial dysfunction is associated with an increased risk for postoperative myocardial injury in patients undergoing noncardiac surgery ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Preoperative SARS-CoV-2 infection increases risk of early postoperative cardiovascular complications following noncardiac surgery

SenthilKumar

Verhagen

Sheriff

et al. 2023

American Journal of Physiology-Heart and Circulatory Physiology

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As the COVID-19 pandemic progresses to an endemic phase, a greater number of patients with a history of COVID-19 will undergo surgery. Major adverse cardiovascular and cerebrovascular events (MACE) are the primary contributors to postoperative morbidity and mortality; however, studies assessing the relationship between a previous SARS-CoV-2 infection and postoperative MACE outcomes are limited. Here, we analyzed retrospective data from 457,804 patients within the N3C Data Enclave-the largest national, multi-institutional dataset on COVID-19 in the United States. 7.4% of patients had a history of COVID-19 prior to surgery. When controlling for comorbidities, age, race, and risk of surgery, patients with preoperative COVID-19 had an increased risk for 30-day postoperative MACE. MACE risk was influenced by an interplay between COVID-19 disease severity and time between surgery and infection; in those with mild disease, MACE risk was not increased even among those undergoing surgery within 4 weeks following infection. In those with moderate disease, risk for postoperative MACE was mitigated 8 weeks after infection, while patient with severe disease continued to have elevated postoperative MACE risk even after waiting 8 weeks. Being fully vaccinated decreased the risk for postoperative MACE in both patients with no history of COVID-19 and in those with breakthrough COVID-19 infection. Together, our results suggest that a thorough assessment of the severity, vaccination status, and timing of SARS-CoV-2 infection must be a mandatory part of perioperative stratification.

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Section: Discussionmentioning

confidence: 99%

Preoperative SARS-CoV-2 infection increases risk of early postoperative cardiovascular complications following noncardiac surgery

SenthilKumar

Verhagen

Sheriff

et al. 2023

American Journal of Physiology-Heart and Circulatory Physiology

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“…12 Several works have focused on the importance of myocardial damage and the close relationship with the LC syndrome; in contrast, the evidence on vascular damage present during LC is still scarce. 7,13,14 The aim of the present commentary is to consider vascular damage during LC and to design a pathway that from pathophysiological aspects leads to the clinic. This should facilitate the diagnosis and management of vascular LC.…”

Section: Introductionmentioning

confidence: 99%

“…Several works have focused on the importance of myocardial damage and the close relationship with the LC syndrome; in contrast, the evidence on vascular damage present during LC is still scarce. 7,13,14…”

Section: Introductionmentioning

confidence: 99%

Vascular “Long COVID”: A New Vessel Disease?

et al. 2023

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Vascular sequelae following (SARS-CoV-2 coronavirus disease) (COVID)-19 infection are considered as “Long Covid (LC)” disease, when occurring 12 weeks after the original infection. The paucity of specific data can be obviated by translating pathophysiological elements from the original Severe Acute Respiratory Syndrome-Corona Virus (SARS-CoV-2) infection (In a microcirculatory system, a first “endotheliitis,” is often followed by production of “Neutrophil Extracellular Trap,” and can evolve into a more complex leukocytoklastic-like and hyperimmune vasculitis. In medium/large-sized vessels, this corresponds to endothelial dysfunction, leading to an accelerated progression of pre-existing atherosclerotic plaques through an increased deposition of platelets, circulating inflammatory cells and proteins. Associated dysregulated immune and pro-coagulant conditions can directly cause thrombo-embolic arterial or venous complications. In order to implement appropriate treatment, physicians need to consider vascular pathologies observed after SARS-Cov-2 infections as possible “LC” disease.

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Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study

Escobar

Peçanha

Duque

et al. 2023

Microvascular Research

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Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)

Cited by 5 publications

References 26 publications

Preoperative SARS-CoV-2 infection increases risk of early postoperative cardiovascular complications following noncardiac surgery

Preoperative SARS-CoV-2 infection increases risk of early postoperative cardiovascular complications following noncardiac surgery

Vascular “Long COVID”: A New Vessel Disease?

Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study

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