Susceptibility to first choice antimicrobial treatment for urinary tract infections to Escherichia coli isolates from women urine samples in community South Brazil

Tano, Zuleica Naomi; Kobayashi, Renata Katsuko Takayama; Candido, Evelyn Poliana; Dias, Juliana Buck; Perugini, Luis Felipe; Vespero, Eliana Carolina; Pavanelli, Wander Rogério

doi:10.1016/j.bjid.2022.102366

Cited by 6 publications

(4 citation statements)

References 36 publications

(44 reference statements)

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“…Most Enterobacteriaceae isolates are susceptible to quinolones and phenicols, which have been considered highly effective treatments for UTIs. Naomi et al [36] obtained the same results. Quinolones are the most frequently selected antibacterials for treating uncomplicated UTIs in many countries [31,32].…”

Section: Disk Diffusion Susceptibility Testingmentioning

confidence: 52%

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Benmoumou

Hamaidi-Chergui

Bouznada

et al. 2023

Advanced Research in Life Sciences

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Urinary tract infections (UTIs) are currently one of the most important medical practice visits. The spread of antibiotic-resistant bacteria in the community complicates the therapeutic management. The aim of this study is to investigate the bacteria associated with community acquired urinary tract infections (CA-UTIs) and the antibiotic resistance pattern of bacterial isolates during 2021 in Algiers, northern Algeria. A total of 548 urine samples from patients with CA-UTIs symptoms were analyzed. Pure bacterial isolates were identified using morphological and biochemical characteristics, and subjected to antibiogram evaluation using the disk diffusion method. A total 133 out of 548 patients (24.27%) had positive CA-UTIs, mainly affecting women (84.21%). A percentage of 87.22% of isolates were identified as Enterobacteriaceae, which were represented mostly by Escherichia coli (76 isolates), Klebsiella pneumoniae (13 isolates), and Proteus mirabilis (13 isolates). A number of 125 isolates (93.98%) were resistant to at least one antibiotic tested. The results showed the highest antibiotic resistance to ampicillin (92.24%) and amoxicillinclavulanic acid (91.37%), and revealed the most sensitivity to cefotaxime and nitrofurantoin (95.69%) and colistin (93.11%). The results of this study revealed high concerns about CA-UTIs caused by multidrug-resistant Enterobacteriaceae.

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Section: Disk Diffusion Susceptibility Testingmentioning

confidence: 52%

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Benmoumou

Hamaidi-Chergui

Bouznada

et al. 2023

Advanced Research in Life Sciences

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“…Pandemic ExPEC lineages, such as ST131, have also been central to a global increase in extended-spectrum β-lactamase (ESBL)producing E. coli, as well as resistance to other clinically important antibiotic classes [4,7,8]. A combination of sulphonamide and trimethoprim is a standard treatment for UTIs but resistance rates to these frontline antibiotics are increasing globally, leading to the elevated use of extended-spectrum β-lactams and fluoroquinolones [9][10][11][12][13]. Previously we performed whole genome sequencing (WGS) on 67 trimethoprim-resistant ExPEC from patients attending a regional Australian hospital in 2006-2008 [14] and reported genes conferring resistance to extended-spectrum β-lactams, heavy metals and quaternary ammonium ions co-occurring with genes encoding resistance to trimethoprim.…”

Section: Introductionmentioning

confidence: 99%

Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids

Elankumaran

Kudinha

et al. 2023

Microbial Genomics

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Extraintestinal pathogenic Escherichia coli (ExPEC) are the most frequent cause of urinary tract infections (UTIs) globally. Most studies of clinical E. coli isolates are selected based on their antimicrobial resistance (AMR) phenotypes; however, this selection bias may not provide an accurate portrayal of which sequence types (STs) cause the most disease. Here, whole genome sequencing (WGS) was performed on 320 E. coli isolates from urine samples sourced from a regional hospital in Australia in 2006. Most isolates (91%) were sourced from patients with UTIs and were not selected based on any AMR phenotypes. No significant differences were observed in AMR and virulence genes profiles across age sex, and uro-clinical syndromes. While 88 STs were identified, ST73, ST95, ST127 and ST131 dominated. F virulence plasmids carrying senB-cjrABC (126/231; 55%) virulence genes were a feature of this collection. These senB-cjrABC+ plasmids were split into two categories: pUTI89-like (F29:A-:B10 and/or >95 % identity to pUTI89) (n=73) and non-pUTI89-like (n=53). Compared to all other plasmid replicons, isolates with pUTI89-like plasmids carried fewer antibiotic resistance genes (ARGs), whilst isolates with senB-cjrABC+/non-pUTI89 plasmids had a significantly higher load of ARGs and class 1 integrons. F plasmids were not detected in 89 genomes, predominantly ST73. Our phylogenomic analyses identified closely related isolates from the same patient associated with different pathologies and evidence of strain-sharing events involving isolates sourced from companion and wild animals.

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“…SARS-CoV-2 together with the Bat_SARS-like coronavirus forms a distinct strain in the sarbecovirus subtype [6]. Opportunistic pathogens can bring superinfections as Urinary tract infection (UTI) and respiratory tract infection (RTI) in hospitalized patients, particularly when they coexist with viral respiratory tract infections [7]. UTI and RTI are the most common infections in hospitals, accounting for up to 35% of nosocomial infections, and the second most prevalent source of bacteremia in hospitalized patients [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bacterial coinfections and susceptible antibiotic profiles in hospitalized COVID-19 patients in Koya district, Iraq

Omar,

Mustafa

2023

J Infect Dev Ctries

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Introduction: Bacterial coinfection among intensive care unit (ICU) COVID-19 patients is not widely studied in Iraq. Hence, the current study was performed to determine the prevalence of secondary bacterial infection and susceptible profile in ICU patients with COVID-19 infections. Methodology: The study was conducted from November 2021 to April 2022, in Mad Center/ Shahid Doctor Khalid Hospital/Koya district. The midstream urine (MSU), sputum, and throat swab (TS) were obtained. Age, gender, clinical characteristics, bacterial identities, and antibiotic sensitivity profiles were collected for 200 COVID-19 patients. The standard biochemical tests confirmed the bacterial isolates. Antibiotic susceptibility was implemented by using the disk diffusion method. Results: Out of 200 ICU patients, 87 (43.5%) of them had bacterial coinfection. The most predominant bacteria were isolated Acinetobacter baumannii (25.3%), Escherichia coli (18.3%), Pseudomonas aeruginosa (16%), Klebsiella pneumonia (11.5%), followed by Staphylococcus aureus (4.6%), and Enterococcus spp. (3.5%). Gram-negative bacteria showed a high level of sensitivity to Ertapenem (90.7%) and Piperacillin/Tazobactam (84.9%). Gram-positive isolates showed high sensitivity to Teicoplanin (77.2%) and Rifampicin (71%). Conclusions: The susceptibility rate of the isolated bacteria is moderate; this indicates that early diagnosis of coinfections and more accurate use of antibiotics are necessary to mitigate the severity of COVID-19.

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Susceptibility to first choice antimicrobial treatment for urinary tract infections to Escherichia coli isolates from women urine samples in community South Brazil

Cited by 6 publications

References 36 publications

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids

Evaluation of bacterial coinfections and susceptible antibiotic profiles in hospitalized COVID-19 patients in Koya district, Iraq

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