The impact of hepatitis E infection on hepatic fibrosis in liver transplanted patients for hepatitis C infection

Moraes, Adriano Claudio Pereira de; Gomes‐Gouvêa, Michele Soares; Ferreira, Ariana Carolina; Pinho, João Renato Rebello; Mello, Evandro Sobroza de; D’Albuquerque, Luiz Augusto Carneiro; Abdala, Edson; Carrilho, Flair José

doi:10.1016/j.bjid.2021.101587

Cited by 2 publications

(3 citation statements)

References 15 publications

(22 reference statements)

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“…The anti-HEV IgG prevalence of 10.2% found in the present study is comparable to those reported in two studies employing the Mikrogen kit in the evaluation of LTRs in southeastern Brazil (8.1% and 8.2%), albeit lower than the 18.7% reported in a study employing the Wantai kit in the evaluation of LTRs in the southern region of the country [ 26 , 27 , 28 ]. Southern is the region with the highest number of pig farms as well as the highest consumption of pork, and the prevalence of anti-HEV IgG positivity has been reported to be higher (up to 40.3%) there than in any other region of the country [ 28 , 29 , 30 ].…”

Section: Discussionsupporting

confidence: 75%

“…In Brazil, within and outside the context of SOT, there is a low detection rate for HEV RNA, which has been reported to be undetectable in some studies. In a study of 294 LTRs in southeastern Brazil, HEV RNA was detected in only 5.8% [ 27 ]. In a study of 80 LTRs in the southern region of the country, no HEV RNA was detected in any of the recipients [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

Zicker,

Pinho,

Welter

et al. 2024

Viruses

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The hepatitis E virus is a major etiological agent of chronic hepatitis in immunosuppressed individuals. Seroprevalence in the liver transplantation setting varies according to the seroprevalence of the general population in different countries. This was a prospective cohort study of liver transplant recipients in southeastern Brazil. Recipients were systematically followed for one year, with the objective of determining the prevalence, incidence, and natural history of HEV infection in this population. We included 107 liver transplant recipients and 83 deceased donors. Positivity for anti-HEV IgG was detected in 10.2% of the recipients and in 9.7% of the donors. None of the patients tested positive for HEV RNA at baseline or during follow-up. There were no episodes of reactivation or seroconversion, even in cases of serological donor-recipient mismatch or in recipients with acute hepatitis. Acute and chronic HEV infections seem to be rare events in the region studied. That could be attributable to social, economic, and environmental factors. Our data indicate that, among liver transplant recipients, hepatitis E should be investigated only when there are elevated levels of transaminases with no defined cause, as part of the differential diagnosis of seronegative hepatitis after transplantation.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

Zicker,

Pinho,

Welter

et al. 2024

Viruses

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“…The results reported were 12.5%, 23.5%, and 40%, respectively ( 28 ). In another study published by de Moraes et al , the analysis showed viral agents-related cirrhosis (HCV, HBV, and HBV/HCV co-infection), especially HCV infection, were associated with the highest positivity rates of anti-HEV IgG and detection of HEV-RNA ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Higher Risk of Chronic Hepatitis E Virus infection in Patients with Human Immunodeficiency Virus-1: An Iranian Cross- sectional Study

et al. 2023

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Background & Objective: Occurrence of Hepatitis E Virus (HEV) infection may be common in Human Immunodeficiency Virus (HIV-1) patients and may lead to chronic infection as well as cirrhosis. We intended to determine the incidence of HEV infection among HIV-1 patients compared to individuals without HIV-1 infection. Methods: In our cross-sectional study, 87 HIV-1-positive patients were compared to 93 healthy individuals in Kerman, Iran. Plasma and peripheral blood mononuclear cells (PBMCs) were obtained from all the participants. Plasma samples were evaluated for HEV IgM and IgG using the ELISA kit. Then, reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) was used in RNA extractions from PBMCs to check for the presence of HEV RNA. Results: Among the subjects examined in our study, 61 (70.1%) and 71 (77.4%) out of patients with HIV-1 infection and healthy individuals were male, respectively. The average ages of patients with HIV-1 and the control group were 40.2 years and 39.9 years, respectively. No discernible differences were found between the two groups based on IgM and IgG seropositivity against the HEV. However, HEV-RNA was found in 8% of patients with HIV-1 and 1.1% of HIV-1-negative individuals (P=0.03). There was also an association between the HEV genome and anti-HEV and anti-HCV antibodies in HIV-1-positive patients (P=0.02 and P=0.014, respectively). Conclusion: HEV infection may be more common in HIV-1 patients and may develop a chronic infection in immunocompromised individuals. Molecular-based HEV diagnostic tests, including RT-PCR assays, should be performed in HIV-1 patients with unknown impaired liver function tests.

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The impact of hepatitis E infection on hepatic fibrosis in liver transplanted patients for hepatitis C infection

Cited by 2 publications

References 15 publications

The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

Higher Risk of Chronic Hepatitis E Virus infection in Patients with Human Immunodeficiency Virus-1: An Iranian Cross- sectional Study

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