“…Acute and PACS are characterized by a large panel of clinical manifestations ranging from asymptomatic symptoms to fatal respiratory failure, and are often associated with manifestations shared with SAD such as musculoskeletal, dermatological, pulmonary, digestive, cardiovascular, kidney injury, thromboembolic events and neurological symptoms [ 83 , 86 , 92 , [114] , [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] ]). Potential mechanisms contributing to SAD-associated clinical symptoms include direct virus replication in acute/chronic infection, inflammation, and immune changes in response to the infection [ 126 ].…”