Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Bandeira, António; Gois, Luana Leandro; Campos, Gúbio Soares; Sardi, Sílvia Inês; Yssel, Hans; Vieillard, Vincent; Autran, Brigitte; Grassi, Maria Fernanda Rios

doi:10.1016/j.bjid.2020.08.005

Cited by 8 publications

(6 citation statements)

References 25 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies demonstrate that the targets of this work have differential expression during the period of ZIKV infection, which therefore suggests the possible use of these markers to ascertain harm during infection by this virus (40)(41)(42).…”

Section: This Possible Relation Between Infection Time and Target Mrn...mentioning

confidence: 87%

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Mendes

Melo

Luna

et al. 2022

Preprint

View full text Add to dashboard Cite

The Zika virus (VZIK) is a Flavivirus of the Flaviviridae family. With the ability to infect neural progenitor cells, microcephaly is the most serious and irreversible neurological complication associated with ZIKV. In this work, we evaluated the mRNA expression of cytokines involved in the inflammatory process that occurred during Zika virus infection in Mesocricetus auratus. The samples came from the real tissue of animals infected through sexual transmission and comprising 3 different groups of animals (TS-01, TS-02 and ZP-01).The project started with the extraction of viral RNA and mRNA from the kidneys of ZIKV-infected animals. After this step, RT-qPCR was carried out to quantify both the viral load and the expression of cytokines associated with the inflammatory process that occurred during the ZIKV infection. As can be seen in our results, this work corroborates different studies that demonstrate that ZIKV can infect and cause an inflammatory response to the kidneys, even causing a high viral load.

show abstract

Section: This Possible Relation Between Infection Time and Target Mrn...mentioning

confidence: 87%

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Mendes

Melo

Luna

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…ZIKV belongs to the RNA virus in the Flaviviridae family, closely related to other flaviviruses, including DENV, West Nile virus, Japanese encephalitis virus, Chikungunya virus, and yellow fever virus ( Arora, 2020 ). Zika infection was closely related to CNS and PNS diseases, in particular stroke or transient ischemic attack, GBS ( Ferreira et al, 2020 ), meningoencephalitis, transverse myelitis ( Da Silva et al, 2017 ), retroorbital pain ( Sharma et al, 2020 ), and myalgia ( Bandeira et al, 2020 ). Evidence has shown a close relationship between Zika infection during pregnancy, congenital abnormalities, and microcephaly ( Mlakar et al, 2016 ).…”

Section: Neurological Manifestations Of Emerging Infectious Diseasesmentioning

confidence: 99%

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

et al. 2021

View full text Add to dashboard Cite

Growing studies are revealing the critical manifestations of influenza, dengue virus (DENV) infection, Zika virus (ZIKV) disease, and Ebola virus disease (EVD) as emerging infectious diseases. However, their corresponding mechanisms of major complications headed for neuronal dysfunction are not entirely understood. From the mechanistic point of view, inflammatory/oxidative mediators are activated during emerging infectious diseases towards less cell migration, neurogenesis impairment, and neuronal death. Accordingly, the virus life cycle and associated enzymes, as well as host receptors, cytokine storm, and multiple signaling mediators, are the leading players of emerging infectious diseases. Consequently, chemokines, interleukins, interferons, carbohydrate molecules, toll-like receptors (TLRs), and tyrosine kinases are leading orchestrates of peripheral and central complications which are in near interconnections. Some of the resulting neuronal manifestations have attracted much attention, including inflammatory polyneuropathy, encephalopathy, meningitis, myelitis, stroke, Guillain-Barré syndrome (GBS), radiculomyelitis, meningoencephalitis, memory loss, headaches, cranial nerve abnormalities, tremor, and seizure. The complex pathophysiological mechanism behind the aforementioned complications urges the need for finding multi-target agents with higher efficacy and lower side effects. In recent decades, the natural kingdom has been highlighted as promising neuroprotective natural products in modulating several dysregulated signaling pathways/mediators. The present study provides neuronal manifestations of some emerging infectious diseases and underlying pathophysiological mechanisms. Besides, a mechanistic-based strategy is developed to introduce candidate natural products as promising multi-target agents in combating major dysregulated pathways towards neuroprotection in influenza, DENV infection, ZIKV disease, and EVD.

show abstract

“…ZIKV is known to also infect liver cells including the hepatocytes 9 . The infection induced liver inflammation or hepatitis which can result in liver damage and dysfunction in infected patients 10 , 11 . To date, there is no specific antiviral or vaccine available to treat or prevent ZIKV infection.…”

Section: Introductionmentioning

confidence: 99%

Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells

Chin

Zainal

Sam

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Neonatal microcephaly and adult Guillain–Barré syndrome are severe complications of Zika virus (ZIKV) infection. The robustly induced inflammatory cytokine expressions in ZIKV-infected patients may constitute a hallmark for severe disease. In the present study, the potential role of high mobility group box 1 protein (HMGB1) in ZIKV infection was investigated. HMGB1 protein expression was determined by the enzyme-linked immunosorbent assay (ELISA) and immunoblot assay. HMGB1’s role in ZIKV infection was also explored using treatment with dexamethasone, an immunomodulatory drug, and HMGB1-knockdown (shHMGB1) Huh7 cells. Results showed that the Huh7 cells were highly susceptible to ZIKV infection. The infection was found to induce HMGB1 nuclear-to-cytoplasmic translocation, resulting in a > 99% increase in the cytosolic HMGB1 expression at 72-h post-infection (h.p.i). The extracellular HMGB1 level was elevated in a time- and multiplicity of infection (MOI)-dependent manner. Treatment of the ZIKV-infected cells with dexamethasone (150 µM) reduced HMGB1 extracellular release in a dose-dependent manner, with a maximum reduction of 71 ± 5.84% (P < 0.01). The treatment also reduced virus titers by over 83 ± 0.50% (P < 0.01). The antiviral effects, however, were not observed in the dexamethasone-treated shHMGB1 cells. These results suggest that translocation of HMGB1 occurred during ZIKV infection and inhibition of the translocation by dexamethasone coincided with a reduction in ZIKV replication. These findings highlight the potential of targeting the localization of HMGB1 in affecting ZIKV infection.

show abstract

Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Cited by 8 publications

References 25 publications

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Analysis of cytokine mRNA expression during Zika infection in Mesocricetus auratus

Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals

Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells

Contact Info

Product

Resources

About