Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients

Comerlato, Pedro Henrique; Stefani, Joel; Viana, Marina Verçoza; Viana, Luciana Verçoza

doi:10.1016/j.bjid.2020.02.002

Cited by 5 publications

(5 citation statements)

References 31 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased doses of glucose and fat were independent factors for early pediatric ICU (PICU) survival ( 43 ). Previous studies have confirmed that the amount of calories can also affect prognosis ( 44 , 45 ). However, without individual patient data, we could not evaluate these findings.…”

Section: Discussionmentioning

confidence: 80%

RETRACTED: Effect of supplemental parenteral nutrition on all-cause mortality in critically Ill adults: A meta-analysis and subgroup analysis

2022

View full text Add to dashboard Cite

ObjectiveSeveral observational studies have demonstrated that increased nutritional delivery by supplemental parenteral nutrition (SPN) plus enteral nutrition (EN) reduces the rate of all-cause mortality in critically ill patients. Therefore, we aimed to compare and evaluate the effect of SPN plus EN on all-cause mortality in critically ill adults.MethodsRandomized controlled trials were retrieved from PubMed, Embase, Google Scholar, Cochrane Library, and Sinomed (up to May 2021). Adults with severe illness treated with SPN plus EN or with EN alone were enrolled. The risk of bias was evaluated using the Newcastle–Ottawa scale, and a meta-analysis was conducted using Stata software. The primary outcome was all-cause mortality and was evaluated by pooled odds ratio (OR) with the fixed-effects model. Required information size was also calculated using trial sequential analysis.ResultsWe identified 10 randomized controlled trials, with a total of 6,908 patients. No significant differences in rate of all-cause mortality (OR = 0.96, 95% CI: 0.84–1.09, P = 0.518), intensive care unit (ICU) mortality (OR = 0.90, 95% CI: 0.75–1.07, P = 0.229), and hospital mortality (OR = 0.95, 95% CI: 0.82–1.10, P = 0.482) were found between the SPN plus EN and EN alone groups. SPN plus EN support was associated with a significantly decreased risk of infection (OR = 0.83, 95% CI: 0.74–0.93, P = 0.001), although the duration of mechanical ventilation [standardized mean difference (SMD) = − 0.20], length of hospital stay (SMD = 0.12), and ICU stay (SMD = − 0.57) were similar between the two groups (all P > 0.05). Meta-regression analyses showed no significant correlations between all-cause mortality and baseline clinical factors, including patients’ age, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, time of SPN initiation, and follow-up duration (all P > 0.05). Subgroup analysis showed that SPN plus EN support was associated with a trend toward decreased rate of all-cause mortality in studies with follow-up < 30 days (OR = 0.61, 95% CI: 0.36–1.02, P = 0.058). Trial sequence analysis showed that the required information size for all-cause mortality was 16,972, and the cumulative Z-curve indicated no significant differences in the risk of all-cause mortality between the two groups (P > 0.05).ConclusionSPN plus EN support can significantly reduce the risk of infection, although it has no significant effect on all-cause mortality among critically ill patients. More studies are warranted to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 80%

RETRACTED: Effect of supplemental parenteral nutrition on all-cause mortality in critically Ill adults: A meta-analysis and subgroup analysis

2022

View full text Add to dashboard Cite

show abstract

“…[ 12 13 ] However, multiple studies have documented fewer infectious complications with preoperative TPN administration in malnourished patients undergoing general surgery. [ 6 14 15 ] Central line-related infections range from 9% to 15% in recent studies,[ 16 17 ] and higher than 30% in older studies. [ 18 19 ] Central lines that are inserted for parenteral nutrition carry a higher risk of line infection than other insertion indications.…”

Section: Discussionmentioning

confidence: 99%

The impact of preoperative total parenteral nutrition on the surgical complications of Crohn’s disease: A retrospective cohort study

Traiki

Aljomah

Alsalouli

et al. 2022

Saudi Journal of Gastroenterology

View full text Add to dashboard Cite

Background: Crohn’s disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients, with a significant impact on disease outcomes. In this single-center retrospective cohort study, we aimed to investigate the impact of total parenteral nutrition (TPN) on the surgical outcomes of patients with CD. Methods: This study included patients with CD who underwent abdominal surgery. We compared patients who received preoperative total parenteral nutrition (TPN group) to those who did not (non-TPN group). Prolonged oral intolerance, albumin level <30 g/L, and body mass index <18.5 were the main indications for TPN. We evaluated postoperative surgical complications in both groups. Results: Between January 2010 and October 2018, 169 eligible patients underwent abdominal surgery. The TPN and non-TPN groups included 40 and 129 patients, respectively. The mean albumin level was significantly lower in the TPN group ( P = 0.013). Laparoscopic surgery was performed in 76.9% of the patients, with a conversion rate of 11.6%. Infectious and non-infectious complications developed in 8.9% and 16% of patients, respectively. Surgical complications were comparable between the groups ( P >0.05). Conclusions: Despite oral intake intolerance and severe disease in the TPN group, the surgical complications were comparable between the groups.

show abstract

“…Catheter-related bloodstream infection (CRBSI) is a serious complication that can frequently occur with up to 18 catheter infectious events in 1,000 catheter days 20. It is most often caused by poor management of the catheter insertion site.…”

Section: Treatment Optionsmentioning

confidence: 99%

“…19 www.Nursing2023.com Catheter-related bloodstream infection (CRBSI) is a serious complication that can frequently occur with up to 18 catheter infectious events in 1,000 catheter days. 20 It is most often caused by poor management of the catheter insertion site. Prolonged use of PN and a lack of enteral feeding may result in small intestine bacterial overgrowth within the gut lining, leading to an increased risk for sepsis.…”

Section: Parenteral Nutritionmentioning

confidence: 99%

Short bowel syndrome with intestinal failure in adults

Vaz

Shannon

Zaloom

2023

Nursing

View full text Add to dashboard Cite

show abstract

Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients

Cited by 5 publications

References 31 publications

RETRACTED: Effect of supplemental parenteral nutrition on all-cause mortality in critically Ill adults: A meta-analysis and subgroup analysis

RETRACTED: Effect of supplemental parenteral nutrition on all-cause mortality in critically Ill adults: A meta-analysis and subgroup analysis

The impact of preoperative total parenteral nutrition on the surgical complications of Crohn’s disease: A retrospective cohort study

Short bowel syndrome with intestinal failure in adults

Contact Info

Product

Resources

About