Thermotolerance of Histoplasma capsulatum at 40 °C predominates among clinical isolates from different Latin American regions

Comparative Proteomic Analysis of Histoplasma capsulatum Yeast and Mycelium Reveals Differential Metabolic Shifts and Cell Wall Remodeling Processes in the Different Morphotypes

“…The thermally dimorphic fungus Histoplasma capsulatum is the etiological agent of histoplasmosis, an important systemic mycosis with a worldwide distribution that is endemic to areas of the United States of America, especially in the Ohio and Mississippi River Valleys, and most Latin American countries (Armstrong et al, 2018;Sahaza et al, 2020). Histoplasmosis causes a wide spectrum of clinical forms, from an asymptomatic, self-limited illness to a progressive disseminated and often fatal disease.…”

Immunoproteomics Reveals Pathogen’s Antigens Involved in Homo sapiens–Histoplasma capsulatum Interaction and Specific Linear B-Cell Epitopes in Histoplasmosis

“…The mycelial form of H. capsulatum is found in the environment and the yeast form is observed during parasitism. Under laboratory conditions, the mycelium form can be cultivated from 25 to 30°C; a temperature switch-up to between 35 and 37°C-in enriched media can reversibly induce the yeast morphotype in this fungus (Sahaza et al, 2020).…”