Infectivity of Simulium damnosum s.l. and therapeutic coverage of ivermectin distribution 10 years post treatment around Owena Dam, Ondo state, Nigeria

Akinsanya, Bamidele; Adewale, Babatunde; Adenusi, Adedotun A.; LAWAL, A.I.; Rahman, Olalekan

doi:10.1016/j.bjid.2019.10.003

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…A combination of cross-sectional and longitudinal compliance was reported by 13 studies, whereby compliance to a defined (43–50) or undefined (51–55) number of rounds were reported, alongside compliance at the latest round of MDA. Four of these studies defined compliance in line with the definitions considered for this review (45,51–53).…”

Section: Resultsmentioning

confidence: 99%

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

Maddren

Gomez

Forbes

et al. 2022

Preprint

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Repeated rounds of mass drug administration are the mainstay of transmission control for five of the 20 recognised neglected tropical diseases (NTDs); soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. MDA programme efficiency is reliant upon participants swallowing treatment consistently at each treatment round, measured by the parameter compliance; the proportion of eligible participants swallowing treatment. Individually linked longitudinal compliance data is crucial for assessing MDA programmes, as such data will elucidate treatment behaviour patterns. Accurate monitoring of compliance across species will require the unanimous acceptance of epidemiological parameters across the research community. This review aims to update the review previously completed by Shuford et al (2016), which predominantly highlighted the interchange of parameters coverage (receiving treatment) and compliance (swallowing treatment). This review aims to find to collect the latest longitudinal compliance data reported by control programmes globally for the five MDA controllable species, searching PubMed and Web of Science in January 2022 for articles written since 2016 in English and Spanish. The review adhered to PRISMA guidelines and is registered with PROSPERO (registration number: CRD42022301991). Study title screening was aided by Rayyan, a machine learning software. Studies were considered for inclusion if primary compliance data for more than one time point, in a population larger than 100 participants were identified. All data analysis was conducted in R. A total of 89 studies were identified containing compliance data, 57 were longitudinal studies, 25 of which reported individually linked data which were analysed further. The association of increasing age with systematic treatment during was commonly reported. The review is limited by paucity of data. It is recommended for WHO to clearly define coverage, compliance, and longitudinal compliance in their treatment guides. Current definitions for species-specific guides contradict each other which may influence the incongruency seen definitions seen in this review.

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Section: Resultsmentioning

confidence: 99%

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

Maddren

Gomez

Forbes

et al. 2022

Preprint

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“…Onchocerciasis has also been associated with a variety of psychosocial and economic impacts. It results in social stigma of infected persons and their families, disturbed sleep and reduced earnings among infected adults, poor school performance and higher dropout rates of children and high health costs (5).…”

Section: Introductionmentioning

confidence: 99%

Serological and parasitological assessment of onchocerciasis transmission and associated factors at Abeshige district, Guragae zone, Southwest Ethiopia: Cross-sectional study

Arega

Feleke

Zeleke

et al. 2023

Preprint

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Background: One of the crippling neglected tropical diseases, onchocerciasis (river blindness), is caused on by the skin-dwelling filarial nematode Onchocerca volvulus, an important vector-borne neglected tropical disease transmitted by the bite of infected black fly. The adult worm lives in the subcutaneous tissues producing thousands of microfilariae that cause skin and eye disease. In Ethiopia, onchocerciasis elimination program has been under way for more than two decades and has been mainly targeting hyper-endemic districts. However, the transmission status in hypoendemic areas wasn’t assessed and targeted for intervention. This study was therefore carried out to assess onchocerciasis transmission status and associated factors in the hypoendemic Abeshige district and generate evidence for program decision making. Objective: This study assessed onchocerciasis transmission status and associated factors in first line villages of Abeshige districts. Method: A community-based cross-sectional study was conducted in three purposively selected first line villages of the Abeshige district from April to May 2022. The study participants (n=300, 100 for each village) were randomly selected and enrolled using single proportion formula. Demographic information and participant’s knowledge, attitude and practices data were collected using a standard questionnaire. Finger prick blood sample for serologic test and skin snip samples for microfilariae examination were collected and examined. Data was entered into Epi-info software version 7.1, and imported to SPSS version 26 software for analysis. The association between dependent and independent variables was done using bivariate logistic regression and the P-value <0.05% was considered statistically significant. Result: out of the 300 examined study participants, 31 (10.1%), 17 (5.7%), 1 (0.33%) were positive by Ov-16 ELISA, Ov-16 RDT and skin snip microscopy, respectively. The participants have poor knowledge, attitude and practice about disease causation, transmission and prevention. None of the study participants have demonstrated palpable nodules, skin depigmentation, blindness, eye inflammation and itching. Age, sex and distance from the river were the independent variables those had significant associations with positivity for Ov-16 ELISA results (P<0.05). Conclusion: the serological prevalence of onchocerciasis was above the WHO recommended threshold (5%) for the implementation of elimination programs. Age, sex and distance from the fast-flowing rivers had significantly associated with positivity of Ov-16 ELISA test. The majority of the population had poor knowledge, attitude and practice about onchocerciasis. Therefore, ivermectin treatment intervention is recommended to be implemented in the district to eliminate the disease. Inclusion of health education in the intervention program is also very important.

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Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

et al. 2023

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Repeated distribution of preventative chemotherapy (PC) by mass drug administration forms the mainstay of transmission control for five of the 20 recognised neglected tropical diseases (NTDs); soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. The efficiency of such programmes is reliant upon participants swallowing the offered treatment consistently at each round. This is measured by compliance, defined as the proportion of eligible participants swallowing treatment. Individually linked longitudinal compliance data is important for assessing the potential impact of MDA-based control programmes, yet this accurate monitoring is rarely implemented in those for NTDs. Longitudinal compliance data reported by control programmes globally for the five (PC)-NTDs since 2016 is examined, focusing on key associations of compliance with age and gender. PubMed and Web of Science was searched in January 2022 for articles written in English and Spanish, and the subsequent extraction adhered to PRISMA guidelines. Study title screening was aided by Rayyan, a machine learning software package. Studies were considered for inclusion if primary compliance data was recorded for more than one time point, in a population larger than 100 participants. All data analysis was conducted in R. A total of 89 studies were identified containing compliance data, 57 were longitudinal studies, of which 25 reported individually linked data reported by varying methods. The association of increasing age with the degree of systematic treatment was commonly reported. The review is limited by the paucity of data published on this topic. The varying and overlapping terminologies used to describe coverage (receiving treatment) and compliance (swallowing treatment) is reviewed. Consequently, it is recommended that WHO considers clearly defining the terms for coverage, compliance, and longitudinal compliance which are currently contradictory across their NTD treatment guidelines. This review is registered with PROSPERO (number: CRD42022301991).

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Infectivity of Simulium damnosum s.l. and therapeutic coverage of ivermectin distribution 10 years post treatment around Owena Dam, Ondo state, Nigeria

Cited by 3 publications

References 24 publications

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

Serological and parasitological assessment of onchocerciasis transmission and associated factors at Abeshige district, Guragae zone, Southwest Ethiopia: Cross-sectional study

Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review

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