Quality of life, risk behaviors and depression among carriers of hepatitis C virus and human T-cell lymphotropic virus type 1: a comparative study

Henrique-Araújo, Ricardo; Caribé, André C.; Argôlo, Felipe Coelho; Jesus-Nunes, Ana Paula; Morais-de-Jesus, Mychelle; Dantas-Duarte, Adriana; Moreira, Tayne Miranda; Oliveira, Irismar Reis de

doi:10.1016/j.bjid.2019.06.013

Cited by 4 publications

(2 citation statements)

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“…They also presented more frequently past major depressive episodes. However, in that study AC and patients with HAM/TSP were not analysed separately [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life

et al. 2020

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Background: HTLV-1 is a neglected sexually transmitted infection despite being the cause of disabling neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is no treatment for this infection and public health policies are essential to reduce its transmission. However, there are no data to support adequate cost-effective analysis in this field. The aim of this study was to obtain health state utility values for individuals with HAM/TSP and HTLV-1 asymptomatic carriers (AC). The impact of both states on quality of life (QoL) is described and compared to other diseases. Methods: A cross-sectional observational study of 141 individuals infected with HTLV-1 (79 with HAM/TSP and 62 AC) from three Brazilian states (Rio de Janeiro, São Paulo and Alagoas) and from the United Kingdom. Participants completed a validated general health questionnaire (EQ-5D, Euroqol) from which country specific health state utility values are generated. Clinical and epidemiological data were collated. Principal findings: Health state utility value for HAM/TSP was 0.2991. QoL for 130 reported clinical conditions ranges from 0.35 to 0.847. 12% reported their quality of life as worse as death. Low QoL was associated with severity rather than duration of disease with a moderate inverse correlation between QoL and Osame’s Motor Disability Score (-0.4933) Patients who are wheelchair dependent had lowest QoL whilst those still walking unaided had the highest. AC also reported impaired QoL (0.7121) compared to general population. Conclusion: HTLV-1 and its associated neurological disease has a marked impact on QoL. This study provides robust data to support the development of cost-utility analysis of interventions for HTLV-1.

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“…They also presented more frequently past major depressive episodes. However, in that study AC and patients with HAM/TSP were not analysed separately [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life

et al. 2020

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“…On the other hand, the more these people are accepted by society and family and away from disgraceful and destructive thoughts about the disease, the more positive their views and attitudes toward life will be and this will help them accept the disease. As a result, they perform self-care behaviors, show high resilience, are hopeful for the future, and are thus happier and less depressed [47].…”

Section: Discussionmentioning

confidence: 99%

Stigma, Anxiety, Depression, and Quality of Life Among Patients With Hepatitis C in Iran

Movahedi

Moshirpanahi²,

Mokhayeri³

et al. 2022

CJHR

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Background: Hepatitis C is one of the most challenging viral infections worldwide. Patients with hepatitis C may experience some disease-related stigma. Objectives: The aim of this study was to evaluate perceived stigma and its role in predicting anxiety, depression, and quality of life among patients with hepatitis C. Materials & Methods: This cross-sectional analytic study was conducted in behavioral counseling centers of three cities, i.e., Khorramabad, Boroujerd and Noorabad, located in the western part of Iran, from May to August 2019. Stratified multistage sampling was used to select 144 patients diagnosed with hepatitis C. The WHOQOL-BREF Scale, Stigma Impact Scale (SIS), Beck Depression Inventory, Second Edition (BDI-II), and Beck Anxiety Inventory, Second Edition (BAI) were used to collect the data. Univariate and multivariate linear regression models were used to estimate the association of covariates on stigma and quality of life. The Stata 16 software was used to analyze the data at the significance level of 0.05. Results: The mean perceived stigma was 66.805 ± 1.291 with social rejection and social isolation achieving the highest scores (23.409 ± 0.551, 20.208 ± 0.437). In the multivariate regression model, depression (B=0.7, 95%; CI: 0.5, 0.89) and anxiety (B=0.21, 95%; CI: 0.02, 0.41) had direct significant associations with stigma independent of age, sex, marital status, and occupation. Depression (B=-0.27, 95%; CI:-0.47, -0.07), anxiety (B=-0.33, 95%; CI: -0.5, -0.16), and stigma (B=-0.41, 95%; CI: -0.56, -0.26) were inversely associated with patients’ quality of life. Conclusion: This study found a high perceived stigma score among HCV patients. Depression and anxiety were significantly associated with stigma. The quality of life of HCV patients were inversely associated with depression, anxiety, and stigma scores.

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Oral health and quality of life of people living with human T-cell leukemia virus-1 in Salvador, Brazil: a cross-sectional study

et al. 2021

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Quality of life, risk behaviors and depression among carriers of hepatitis C virus and human T-cell lymphotropic virus type 1: a comparative study

Cited by 4 publications

References 31 publications

Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life

Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life

Stigma, Anxiety, Depression, and Quality of Life Among Patients With Hepatitis C in Iran

Oral health and quality of life of people living with human T-cell leukemia virus-1 in Salvador, Brazil: a cross-sectional study

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