The first outbreak of measles virus caused by imported genotype D8 in Jiangsu province of China

Deng, Xin; Hu, Ying; Lu, Peishan; Zhou, Minghao; Guo, Haijian

doi:10.1016/j.bjid.2019.02.003

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…The molecular epidemiology surveillance of measles virus was introduced in 2005 and H1a is the unique genotype before October, 2017. Only three D8 genotype cases were identified in 2017 and 2018, respectively [13]. The surveillance of antibody level among health population showed a higher herd immunity [14].…”

Section: Introductionmentioning

confidence: 98%

The phylodynamic of H1a genotype measles virus in Jiangsu province, China, 2005-2017

Lu¹,

Hu²,

Deng³

et al. 2019

Preprint

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Background: The change on the pressures during viruses evolving will cause changes in phylodynamic. To know phylodynamic characteristic of measles virus in high vaccination coverage era, the phylodynamic characteristic was analyzed using nucleoprotein gene sequences of measles viruses isolated from Jiangsu province of China from 2005 to 2017. Methods: Nucleoprotein gene sequences of measles viruses were used to analyze gene distance and construct phylogenetic tree with Markov chain Monte Carlo algorithm. The mean gene distance within each group was computed with MEGA7.0 software. The phylodynamic of measles virus circulating in Jiangsu province was constructed using Bayesian skyline plot analyses. Results: Our results showed that the decline trend is observed in the gene distance of nucleoprotein gene and effective population size of measles virus with time. Two clusters of H1a genotype shows multiple origins and the extinction of variants with time. Conclusion: These findings highlight that phylodynamic of measles viruses is a helpful tool to assess the effectiveness of epidemic control.

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Section: Introductionmentioning

confidence: 98%

The phylodynamic of H1a genotype measles virus in Jiangsu province, China, 2005-2017

Lu¹,

Hu²,

Deng³

et al. 2019

Preprint

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“…The molecular epidemiology surveillance of measles virus was introduced in 2005 and H1a is the predominant genotype. Only three D8 genotype cases were identified in 2017 and 2018, respectively 10,13 14 .…”

Section: Introductionmentioning

confidence: 99%

The genotype distribution and phylodynamic of measles viruses circulating in the east of China in postvaccine era, 2005–2017

Deng

et al. 2021

Journal of Medical Virology

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The increase of the evolutionary pressure will cause phylodynamics changes of viruses. In post‐vaccine coverage era, measles viruses face more immune pressure than ever before. Vice versa, the phylodynamic changes may reflect herd immunity level provided by vaccination. In this study, we analyzed phylodynamic characteristics of measles viruses isolated from 2005 to 2017 in Jiangsu province of China using nucleoprotein gene sequences of measles viruses. The phylogenetic tree was constructed with Markov chain Monte Carlo algorithm. The mean gene distance within each group was computed with MEGA7.0 software. Our results showed that a decline trend is observed in the gene distance of nucleoprotein gene with time as well as incidence of measles from epidemic surveillance system. Two clusters of H1a genotype show cocirculation of multiple variants in early years and the disappearance of most variants with time. We explore the phylodynamic of measles virus under high immune pressure. Our findings highlight that phylodynamic of measles viruses is a helpful tool to assess the effectiveness of epidemic control.

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“…Before 2017, H1a genotype was the unique virus circulating in Jiangsu province. Until October of 2017, Deng et al identified two epidemiologically linked cases caused by D8 genotype measles virus, and the index case might be a student from Lao People's Democratic Republic who studied at college in Jiangsu province [8]. From then, two imported measles cases were reported again in Jiangsu province within two years.…”

Section: Introductionmentioning

confidence: 99%

“…e QIAamp Viral RNA Mini Kit (Qiagen, Hilden, Germany) was used to extract measles virus (MeV) nucleic acid according to the manufacturer's instructions. Reverse transcription amplification was performed using previously described primers to amplify a 634-bp fragment of the N gene [8], which included enough length fragment recommended for genotyping. e PCR products were sequenced using the ABI 3730 DNA Sequencer (Applied Biosystems, Foster City, CA, USA) at Sagon Biotech (Shanghai, China) using directional primers.…”

Section: Introductionmentioning

confidence: 99%

Measles Virus Imported by International Traveler in Jiangsu Province of China, in 2018 and 2019

Deng

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Measles remains a public health concern in many regions, and the imported measles cases continue to challenge the measles elimination program for most of the countries where measles was verified to be eliminated or approaching elimination. The imported measles cases have been reported since October, 2017, in Jiangsu province, China. In this study, we reported the first imported B3 genotype measles virus from Egypt and the second imported D8 genotype measles virus from Philippines through international traveling. No secondary measles cases were found after these imported cases. Our findings highlighted the importance of measles vaccination targeting international travelers in China.

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The first outbreak of measles virus caused by imported genotype D8 in Jiangsu province of China

Cited by 5 publications

References 14 publications

The phylodynamic of H1a genotype measles virus in Jiangsu province, China, 2005-2017

The phylodynamic of H1a genotype measles virus in Jiangsu province, China, 2005-2017

The genotype distribution and phylodynamic of measles viruses circulating in the east of China in postvaccine era, 2005–2017

Measles Virus Imported by International Traveler in Jiangsu Province of China, in 2018 and 2019

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