Secular trends of candidemia at a Brazilian tertiary care teaching hospital

Abstract

There was an improvement in patient care, with an increase in the proportion of patients receiving treatment and a decrease in the time to treatment initiation, but no improvement in the outcome, possibly because the proportion of sicker patients increased over time.

A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpatients in a tertiary teaching hospital in China

“…The change trend was similar to that reported by Oeser et al [38]. The overall morbidity and 30-day mortality in ICUs and hospitals in this study were similar to those in another hospital in this region of China [18], but lower than those in hospitals in other regions of China [35,37] and other countries [5,8,16,20,21,23,25,30]. The overall mortality rate of candidaemia has been reported to be 20-49% globally [39], and the mortality rate was 20.4% in our hospital, which is low compared to the global rate.…”

“…This situation has not been clearly shown in other studies, and more epidemiological investigations are needed for confirmation. The incidence of candidaemia among paediatric patients was significantly higher than that among adults (P < 0.05) ( Table 2); however, no significant difference in mortality was found between paediatric patients and adult patients (P > 0.05) ( Table 2) in contrast to other studies [16,17].…”

A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpaitents in a tertiary teaching hospital in China

“…The change trend was similar to that reported by Oeser et al [38]. The overall morbidity and 30-day mortality in ICUs and hospitals in this study were similar to those in another hospital in this region of China [18], but lower than those in hospitals in other regions of China [35,37] and other countries [5,8,16,20,21,23,25,30]. The overall mortality rate of candidaemia has been reported to be 20%-49% globally [39], and the mortality rate was 20.4% in our hospital, which is low compared to the global rate.…”

“…This situation has not been clearly shown in other studies, and more epidemiological investigations are needed for con rmation. The incidence of candidaemia among paediatric patients was signi cantly higher than that among adults (P<0.05) (Table 2); however, no signi cant difference in mortality was found between paediatric patients and adult patients (P>0.05) ( Table 2) in contrast to other studies [16,17].…”

“…The 7-day and 30-day mortality rates were 8.5% (17/201) and 17.9% (36/201), respectively. The mortality rates of C. albicans, C. glabrata, C. tropicalis and C. parapsilosis infections were 27.2% (22/81), 16 The univariate predictors of poor outcomes due to candidaemia are shown in Table 4. For paediatric patients with candidaemia, the variables associated with 30-day mortality were as follows: length of hospital stay, respiratory dysfunction, chronic/acute renal failure and septic shock.…”