Schistosomal liver fibrosis and hepatocellular carcinoma – case series of patients submitted to liver transplantation

Filgueira, Norma Arteiro; Saraiva, Camilla Maria de Alencar; Jucá, Norma Thomé; Bezerra, Matheus Filgueira; Lacerda, Cláudio Moura

doi:10.1016/j.bjid.2018.06.001

Cited by 12 publications

(13 citation statements)

References 8 publications

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“…Hydroxyasiaticoside has anti-inflammatory, antioxidant, and anti-tumor effects (Filgueira et al, 2018;Chen et al, 2019). However, it had not been established whether hydroxyasiaticoside can improve S. japonicum induced liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis

Fang

You

et al. 2021

Front. Bioeng. Biotechnol.

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Schistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis.Objective:The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis.Methods:Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected with Schistosomia cercariae through the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end of the treatment, mice were sacrificed to collect blood for the determination of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels. Moreover, the liver was excised, weighed, and liver indices were calculated. Histopathological examination was performed to assess liver morphology. Besides, the expression of collagen type I and III in liver was determined; the mRNA expression levels of IL-6 and TNF-α in liver tissues were measured using Real-time PCR while ELISA and western blotting were performed on liver tissue homogenate to determine the protein expression of IL-6 and TNF-α.Results:The combination of praziquantel and hydroxyasiaticoside lowered the pathological scores of schistosomiasis-induced hepatic fibrosis, the liver indice, serum AST and ALT levels, improved liver morphology, downregulated the expression levels of hepatic type I and III collagen, inhibited the mRNA expression levels of pro-inflammatory factors (IL-6 and TNF-α) in the liver of mice relative to the praziquantel alone.Conclusion:The combination of hydroxyasiaticoside and praziquantel is a potential therapeutic option for schistosomiasis-induced hepatic fibrosis. Notably, this combination noticeably suppresses the protein and mRNA expression levels of pro-inflammatory factors (TNF-α and IL-6) in the liver.

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Section: Discussionmentioning

confidence: 99%

In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis

Fang

You

et al. 2021

Front. Bioeng. Biotechnol.

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“…Chronic schistosomiasis is also associated with CRC, liver cancer and bladder cancer (31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer

Wang

Liu

et al. 2020

Oncol Lett

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Patients with schistosomal colorectal cancer (CRC) and nonschistosomal CRC have different clinicopathological features, laboratory test results and survival rates. Long-term infection with schistosomiasis in patients with CRC may affect the pathogenesis and subsequently change the mechanisms of CRC in these patients, resulting in changes in the survival rates of patients with schistosomal and nonschistosomal CRC. In China, the most common type of schistosomiasis is S. japonicum. The present study aimed to investigate the clinicopathological features and prognostic factors of schistosomal and nonschistosomal CRC. A total of 253 patients with schistosomal CRC and 2,885 patients with nonschistosomal CRC were analyzed and their symptoms, clinicopathological features and laboratory test results were retrospectively evaluated. Patients with CRC in the present study underwent radical resection at The First Affiliated Yijishan Hospital of Wannan Medical College between January 2012 and December 2018. A total of 3,138 patients with CRC were enrolled, 253 of whom were patients with schistosomal CRC. Patients were followed-up to examine differences in the 5-year survival rates between patients with schistosomal and nonschistosomal CRC to determine whether schistosomiasis impacted the prognosis of CRC. There were significant differences in age, sex, fecal occult blood positive, pathological T stage, and CA19-9, WBC, RBC and PLT levels between patients with schistosomal CRC and nonschistosomal CRC. For residents in areas with higher levels of schistosomiasis infections, especially middle-aged and elderly males, serum tumor markers and digestive tract endoscopy should be regularly evaluated to detect the presence of digestive tract tumors as early as possible.

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“…Moreover, immunosuppression due to depression of the cell mediated immune response and enhanced expression of lymphocyte activation markers in chronic HCV and S. mansoni induced liver disease, increased with the progression of the disease and was apparently linked with the progress of hepatosplenomegaly [43,44] . Prolonged carrier state of HBV and HCV may occur as an effect of schistosomiasis on the immune system, which carries a higher risk of developing complications including HCC [45,46] . Two hypothesises were proposed for the effects of schistosomiasis on host immune response.…”

Section: Schistosoma Sppmentioning

confidence: 99%

Spotlights on helminth pathogens’ innovative pathways of tumorigenesis

Yousof

Khater²,

El-Sayed³

2022

Parasitologists United Journal

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Chronic infections with microbes, such as viruses, bacteria and parasites contribute to a considerable proportion of the worldwide burden of cancer cases. Helminthic infections cause a relatively small proportion of the infection-related cancers, but the higher exposure to the worldwide helminth infections presents an importance of health problem. Notably, these infections are a preventable cause of cancer that highlights the prevention and control as well as health education in endemic areas to reduce infection levels and consequently reduce the risk of development of infection-related cancers. This review intends to spotlight the association of certain helminth infections with human malignancy and to focus on their innovative pathways of causing neoplasia.

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Schistosomal liver fibrosis and hepatocellular carcinoma – case series of patients submitted to liver transplantation

Cited by 12 publications

References 8 publications

In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis

In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis

Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer

Spotlights on helminth pathogens’ innovative pathways of tumorigenesis

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