Inability to work due to Chikungunya virus infection: impact on public service during the first epidemic in the State of Ceará, northeastern Brazil

Bastos, Maria Luiza Almeida; Abreu, Francileudo Santos de; Silva, Geraldo Bezerra da

doi:10.1016/j.bjid.2018.05.002

Cited by 17 publications

(15 citation statements)

References 4 publications

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“…Patients may also develop a later chronic condition, with persistent or relapse symptoms of arthropathy [7]. As the majority of CHIKV infected patients are symptomatic with varying degrees of joint or musculoskeletal pains and require long-term treatment, CHIKV represents a serious burden inflected on both public health and economic sector [7–9].…”

Section: Introductionmentioning

confidence: 99%

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil

et al. 2019

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The emergence of chikungunya virus (CHIKV) has raised serious concerns due to the virus’ rapid dissemination into new geographic areas and the clinical features associated with infection. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. Our phylogenetic reconstructions indicated the circulation of the East-Central-South-African (ECSA) lineage in Rio de Janeiro. Time-measured phylogenetic analysis combined with CHIKV notified case numbers revealed the ECSA lineage was introduced in Rio de Janeiro around June 2015 (95% Bayesian credible interval: May to July 2015) indicating the virus was circulating unnoticed for 5 months before the first reports of CHIKV autochthonous transmissions in Rio de Janeiro, in November 2015. These findings reinforce that continued genomic surveillance strategies are needed to assist in the monitoring and understanding of arbovirus epidemics, which might help to attenuate public health impact of infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil

et al. 2019

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“…The symptoms are characterized by fever, rash and severe polyarthralgia/polyarthritis that can become chronic and persist from months to years [7]. Mortality rates are estimated to be approximately 0.1% [8]; however, the high attack rates (up to 30–75%) can result in considerable economic burden [9, 10]. The current mainstay of treatment is the use of NSIADs and/or acetaminophen, although relief is often inadequate and more effective treatments are actively being sought [11].…”

Section: Introductionmentioning

confidence: 99%

Systems analysis of subjects acutely infected with the Chikungunya virus

et al. 2019

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The largest ever recorded epidemic of the Chikungunya virus (CHIKV) broke out in 2004 and affected four continents. Acute symptomatic infections are typically associated with the onset of fever and often debilitating polyarthralgia/polyarthritis. In this study, a systems biology approach was adopted to analyze the blood transcriptomes of adults acutely infected with the CHIKV. Gene signatures that were associated with viral RNA levels and the onset of symptoms were identified. Among these genes, the putative role of the Eukaryotic Initiation Factor (eIF) family genes and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC3A) in the CHIKV replication process were displayed. We further compared these signatures with signatures induced by the Dengue virus infection and rheumatoid arthritis. Finally, we demonstrated that the CHIKV in vitro infection of murine bone marrow-derived macrophages induced IL-1 beta production in a mechanism that is significantly dependent on the inflammasome NLRP3 activation. The observations provided valuable insights into virus-host interactions during the acute phase and can be instrumental in the investigation of new and effective therapeutic interventions.

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“…Other extra‐articular effects such as carpal/tarsal/cubital tunnel syndromes, bursitis, tenosynovitis, synovitis, asthenia, fatigue, depression, and disorders of sleep, memory and concentration may further compromise the physical function . Quality of life and workability are generally impaired in later stages of the disease .…”

Section: Introductionmentioning

confidence: 99%

Pain, balance, grip strength and gait parameters of older adults with and without post‐chikungunya chronic arthralgia

Forechi

Silveira-Nunes

Barbosa

et al. 2018

Tropical Med Int Health

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Summary Objective To compare the levels of pain, grip strength, balance and gait in older adults with and without post‐Chikungunya chronic arthralgia (PCCA). Methods Sixty‐two older adults, 30 with and 32 without PCCA participated in the study. Pain level was assessed using a Visual Analogue Scale (VAS). Gait during a 10‐m walk was assessed using inertial sensors. Semi‐static balance was assessed during an eyes‐closed bipedal balance test on a force platform, and grip strength was assessed using a hand dynamometer. Results Participants with PCCA presented severe levels of pain (VAS > 7.5), poorer balance, lower grip strength, walked slower, with lower cadence and stride length and higher stride time and stride length variability than participants without PCCA (P < 0.001 for all variables). Conclusions Older adults with PCCA had high levels of pain, impaired balance and gait and lower grip strength compared to older adults without PCCA.

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Inability to work due to Chikungunya virus infection: impact on public service during the first epidemic in the State of Ceará, northeastern Brazil

Cited by 17 publications

References 4 publications

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil

Systems analysis of subjects acutely infected with the Chikungunya virus

Pain, balance, grip strength and gait parameters of older adults with and without post‐chikungunya chronic arthralgia

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