Zoonotic spillover and emerging viral diseases – time to intensify zoonoses surveillance in Brazil

Ellwanger, Joel Henrique

doi:10.1016/j.bjid.2017.11.003

Cited by 26 publications

(20 citation statements)

References 5 publications

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“…Earlier reports suggested the emergence of SARS-CoV by recombination between bat SARS related coronaviruses (SARSr-CoVs) followed by mutations in civets before its spillover. Similarly, the MERS-CoV also circulated and attained mutations for around 30 years in camels before the MERS pandemic happened (Muller et al, 2014;Cui et al, 2019), suggesting the adaptation of the viruses to the environment and different host before their spillover to humans (Ellwanger and Chies, 2018). Coronaviruses also have an essential replication process, which involves a 2-step replication mechanism.…”

Section: The Emergence Of Coronaviruses (Sars-cov Mers Cov and Sars-mentioning

confidence: 99%

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review

Mandegary¹,

Al-Ahmed²,

Sah³

et al. 2020

Preprint

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A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China has resulted in an outbreak in China which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 175 countries while affecting nearly 500,000 persons and causing more than 22,000 human deaths, it has resulted in a pandemic situation in the world. The SARS-CoV-2 virus belongs to the genus Betacoronavirus, like MERS-CoV and SARS-CoV, all of which originated in bats. It is highly contagious, causing symptoms like fever, dyspnea, asthenia and pneumonia, thrombocytopenia and the severely infected patients succumb to the disease. Coronaviruses (CoVs) among all known RNA viruses have the largest genomes ranging from 26 to 32 kb in length. Extensive research has been conducted to understand the molecular basis of the SARS-CoV-2 infection and evolution, develop effective therapeutics, antiviral drugs and vaccines, and to design rapid and confirmatory viral diagnostics as well as adopt appropriate prevention and control strategies. Till date, no clinically proclaimed, proven therapeutic antibodies or specific drugs and therapeutics, and vaccines have turned up. Several molecular diagnostic tests such as Real Time-PCR, isothermal loop-mediated amplification of coronavirus (i-LACO), full genome analysis by next-generation sequencing (NGS), multiplex nucleic acid amplification, and microarray-based assays are in use currently for the laboratory confirmation of this CoV infection. In this review article, we describe the basic molecular organization and phylogenetic analysis of the coronaviruses, including the SARS-CoV-2, and recent advances in diagnosis and vaccine development in brief and focusing mainly on developing potential therapeutic options that can be explored to manage this pandemic virus infection, which would help in valid countering of COVID-19.

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Section: The Emergence Of Coronaviruses (Sars-cov Mers Cov and Sars-mentioning

confidence: 99%

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review

Mandegary¹,

Al-Ahmed²,

Sah³

et al. 2020

Preprint

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“…Due to evolutionary pressures and acquiring mutations, previously an animal pathogen, now gains the ability to cross the specie barrier, jumping and adapting to a new host i.e. human, which happened in case of SARS, MERS and now COVID-19 [28,29]. Circumstantial evidence suggest that the pandemic started in the seafood market which was a hotspot for buying and selling animals like bats, snakes, poultry etc.…”

Section: Covid-19: Psychological Burdens Pandemic To Infodemicmentioning

confidence: 99%

Ethics, pandemic and environment; looking at the future of low middle income countries

Tanveer

Khalil

Ali

2020

Int J Equity Health

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COVID-19 which started in Wuhan, China and swiftly expanded geographically worldwide, including to Low to Middle Income Countries (LMICs). This in turn raised numerous ethical concerns in preparedness, knowledge sharing, intellectual property rights, environmental health together with the serious constraints regarding readiness of health care systems in LMICs to respond to this enormous public health crisis. From the restrictions on public freedom and burgeoning socio-economic impacts to the rationing of scarce medical resources, the spread of COVID-19 is an extraordinary ethical dilemma for resource constrained nations with less developed health and research systems. In the current crisis, scientific knowledge and technology has an important role to play in effective response. Emergency preparedness is a shared responsibility of all countries with a moral obligation to support each other. This review discusses the ethical concerns regarding the national capacities and response strategies in LMICs to deal with the COVID-19 pandemic as well as the deep link between the environment and the increasing risk of pandemics.

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“…In this context, we must say that emerging diseases are particularly associated with environmental and animal factors. Exogenous zoonotic pathogens commonly undergo mutations and after jumping species barrier opt for adaptation to the hostile environmental conditions before spillover to humans (Ellwanger and Chies, 2018). The interaction between these components is critical in the understating of what happened in the case of the Severe Acute Respiratory Syndrome (SARS), the Middle East Respiratory Syndrome (MERS) and now the Coronavirus Diseases 2019 (COVID-19), bcaused by the SARS-2 Coronavirus (SARS-CoV-2) (Dhama et al, 2020;Rodriguez-Morales, Bonilla-Aldana, et al, 2020) (Figure 1).…”

mentioning

confidence: 99%

Revisiting the One Health Approach in the Context of COVID-19: A Look into the Ecology of this Emerging Disease

Bonilla-Aldana¹,

Dhama²,

Rodríguez‐Morales³

2020

Adv. Anim. Vet. Sci.

153

120

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Zoonotic spillover and emerging viral diseases – time to intensify zoonoses surveillance in Brazil

Cited by 26 publications

References 5 publications

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review

Ethics, pandemic and environment; looking at the future of low middle income countries

Revisiting the One Health Approach in the Context of COVID-19: A Look into the Ecology of this Emerging Disease

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Zoonotic spillover and emerging viral diseases – time to intensify zoonoses surveillance in Brazil

Cited by 26 publications

References 5 publications

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus &ndash; A Review

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus &ndash; A Review

Ethics, pandemic and environment; looking at the future of low middle income countries

Revisiting the One Health Approach in the Context of COVID-19: A Look into the Ecology of this Emerging Disease

Contact Info

Product

Resources

About

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review

SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review