Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil?

Espósito, Danillo Lucas Alves; Fonseca, Benedito Antônio Lopes da

doi:10.1016/j.bjid.2017.06.002

Cited by 90 publications

(78 citation statements)

References 31 publications

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“…For each individual, antigen signal levels were plotted relative to the acute-phase signal level. cocirculating viruses is more likely with the arrival and widespread occurrence of CHIKV, as recently noted for MAYV infections occurring in Brazil between December 2014 and January 2016 that were misreported as CHIKV infections (45). Further, arthritogenic CHIKV and MAYV should remain on surveillance watch lists for potential involvement in disease outbreaks, and improved surveillance tools are needed for this purpose.…”

Section: Figmentioning

confidence: 94%

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

Smith

Pugh

Cisney

et al. 2018

mSphere

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Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America. Human infections by these viruses are frequently underdiagnosed or misdiagnosed, especially in areas with high dengue virus endemicity. Disease may progress to debilitating arthralgia (MAYV, CHIKV), encephalitis (VEEV), and death. Few standardized serological assays exist for specific human alphavirus infection detection, and antigen cross-reactivity can be problematic. Therefore, serological platforms that aid in the specific detection of multiple alphavirus infections will greatly expand disease surveillance for these emerging infections. In this study, serum samples from South American patients with PCR-and/or isolation-confirmed infections caused by MAYV, VEEV, and CHIKV were examined by using a protein microarray assembled with recombinant capsid, envelope protein 1 (E1), and E2 from nine New and Old World alphaviruses. Notably, specific antibody recognition of E1 was observed only with MAYV infections, whereas E2 was specifically targeted by antibodies from all of the alphavirus infections investigated, with evidence of cross-reactivity to E2 of o'nyong-nyong virus only in CHIKV-infected patient serum samples. Our findings suggest that alphavirus structural protein microarrays can distinguish infections caused by MAYV, VEEV, and CHIKV and that this multiplexed serological platform could be useful for high-throughput disease surveillance.IMPORTANCE Mayaro, chikungunya, and Venezuelan equine encephalitis viruses are closely related alphaviruses that are spread by mosquitos, causing diseases that produce similar influenza-like symptoms or more severe illnesses. Moreover, alphavirus infection symptoms can be similar to those of dengue or Zika disease, leading to underreporting of cases and potential misdiagnoses. New methods that can be used to detect antibody responses to multiple alphaviruses within the same assay would greatly aid disease surveillance efforts. However, possible antibody cross-reactivity between viruses can reduce the quality of laboratory results. Our results demonstrate that antibody responses to multiple alphaviruses can be specifically quantified within the same assay by using selected recombinant protein antigens and further show that Mayaro virus infections result in unique responses to viral envelope proteins.

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Section: Figmentioning

confidence: 94%

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

Smith

Pugh

Cisney

et al. 2018

mSphere

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“…In terms of vaccination, two experimental MAYV vaccines are currently being tested in animal experiments and are expected to continue into clinical experimentation. 16 Epidemiologically, contact tracing and isolation are important control strategies. Contact tracing can be a useful strategy to identify unreported cases of MAYV disease since people living in the same conditions as the patient during the same timeframe are likely to have a similar exposure to the mosquito vector.…”

Section: Proposed Control Methodsmentioning

confidence: 99%

“…5,[11][12][13][14][15] In addition, co-infection with Dengue virus has previously been described. 15 Moreover, immune cross-reactivity with either other Semliki complex viruses in hemagglutinin inhibition and complement fixation assays 16 or other alphaviruses such as Chikungunya virus in antibody assays (i.e. enzyme-linked immunosorbent assays [ELISAs]) 17 may pose a diagnostic challenge.…”

Section: Izurieta Et Almentioning

confidence: 99%

Mayaro virus: the jungle flu

Izurieta¹,

DeLacure²,

Izurieta³

et al. 2018

VAAT

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Abstract:Mayaro fever is an emerging acute viral disease endemic in Central and South America. Mayaro virus (MAYV) is classified in the Semliki Forest virus antigenic complex and shares similarities with the alphavirus Chikungunya virus and the flavivirus Dengue virus. MAYV is an arbovirus transmitted by Haemagogus janthinomys, with competence also demonstrated in Aedes aegypti, Aedes scapularis, and Anopheles quadrimaculatus. Outbreaks and small epidemics of Mayaro fever have occurred in several countries in northern South America and the Caribbean. In addition, travel-associated cases have been reported in European nationals returning from endemic areas. Clinical features of Mayaro fever include fever, chills, persistent arthralgia, retro-orbital pain, maculopapular rash, itching, dizziness, and, rarely, lymphadenopathy. Methods of control for MAYV are similar to those used for other sylvatic arboviruses. Although MAYV was discovered as long ago as the 1950s and continues to be prevalent in the tropical areas of the Americas, it remains neglected and under-studied. This paper provides a thorough and current review of the published MAYV literature ranging from its original description to modern outbreaks, and from the basic virus characteristics to the clinical and epidemiological aspects of this disease.

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“…It should, however, be noted that arboviruses are most often not easily transmittable by transfusion and the reason for this is unknown. There are other arboviruses that could potentially cause TT but with no reported cases and for which screening is not performed, like Mayaro virus and Rift River Valley virus . These viruses could be candidates for the next outbreak along with Ross River virus, which already has reported TT but where recall and donation restrictions are considered adequate to supersede screening .…”

Section: Some Current Eids Relevant For Blood Safetymentioning

confidence: 99%

Emerging infectious diseases and blood donation

Kjerulff

Erikstrup

2018

ISBT Science Series

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Emerging infectious diseases (EIDs) require vigilance from blood banks everywhere. As EIDs spread to new areas and populations, blood banks are forced to re‐evaluate safety measures continually. Screening, pathogen inactivation and deferral policies must be balanced against supply, safety and cost‐effectiveness. One size does not fit all, and blood banks must adjust to local needs and conditions when considering initiation or halting of screening, pathogen inactivation or deferral procedures to balance between demand/supply, safety and economy.

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Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil?

Cited by 90 publications

References 31 publications

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

Mayaro virus: the jungle flu

Emerging infectious diseases and blood donation

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