Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population

Rani, Asima; Nawaz, Syed Kashif; Irfan, Shazia; Arshad, Muhammad; Bashir, Razia; Shaheen, Najma

doi:10.1016/j.bjid.2017.04.002

Cited by 7 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An important SNP rs8177374 has been reported in association with inflammatory diseases, tuberculosis, bacteremia, pneumococcal disease and malaria in some ethnic populations (Khor et al, 2007;Castiblanco et al, 2008). Our findings also reported association of this polymorphism with malaria in the Pakistani population (Rani et al, 2017). Another non-synonymous SNP in TIRAP, rs8177400 causes nucleotide change of guanine (G) to adenine (A) at position 722.…”

Section: Introductionsupporting

confidence: 62%

“…Now it has been established that P. vivax infection can also develop severe malarial outcomes (Jain et al, 2008). Development of complicated malaria in some subjects posited the importance of host immune response instead of the type of invading parasite (Rani et al, 2017). We didn't observe any association between rs8177400 and complicated malaria.…”

Section: Discussionmentioning

confidence: 66%

“…Association of this SNP has been studied with malaria in Gambian (Nejentsev et al, 2008), Iranian Balochi (Zakeri et al, 2011), Indian (Panda et al, 2016) and Brundian population (Esposito et al, 2012). Protective effects of heterozygous forms of rs8177374 against malaria were also reported in the Pakistani population (Rani et al, 2017). rs8177400 (G/A) is another important nonsynonymous SNP in the TIRAP gene.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association of TIR Domain Containing Adaptor Protein (TIRAP) Gene Variant rs8177400 with Susceptibility and Clinical Outcomes of Plasmodium Infection in the Pakistani Population

Rani¹,

Nawaz²,

Arshad³

2020

PJZ

Self Cite

View full text Add to dashboard Cite

This case control study was aimed to determine the role of rs8177400 polymorphism in TIR-domaincontaining-adaptor-protein gene in malaria susceptibility and clinical outcomes upon P. falciparum and P. vivax exposure. Blood samples of 228 malaria patients and 226 healthy controls were selected from the local population. Malarial samples were divided in to complicated malaria (N=89) and mild malaria (N=139) groups according to WHO criteria. Malarial groups were further divided into P. vivax and P. falciparum groups based on the Plasmodium species responsible for the infection. Allele specific PCR was employed for the amplification of rs8177400 polymorphism. Results of genotyping were confirmed via PCR-RFLP strategy. Presence of GG genotype decreases the susceptibility of malaria (OR: 0.544, CI: 0.331 to 0.894, p=0.053), mild malaria (OR: 0.472, CI: 0.274 to 0.815, p=0.024) and P. vivax infection (OR: 0.362, CI: 0.211 to 0.622, p=0.000). AG heterozygosity increased the susceptibility of malaria (OR: 1.835, CI: 1.117 to 3.013, p=0.053), mild malaria (OR: 2.115, CI: 1.226 to 3.649, p=0.024) and P. vivax infection (OR: 2.758, CI: 1.607 to 4.732, p=0.000). GG genotype decreased the risk of mild malaria due to P. vivax infection (OR: 0.312, 95% CI: 0.170 to 0.572, p=0.000). AG genotype increased the chances of mild malaria due to P. vivax infection (OR: 3.205, 95% CI: 1.747 to 5.878, p=0.000). P. vivax infection may develop mild malaria symptoms in AG carriers of rs8177400 polymorphism in the Pakistani population.

show abstract

Section: Introductionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of TIR Domain Containing Adaptor Protein (TIRAP) Gene Variant rs8177400 with Susceptibility and Clinical Outcomes of Plasmodium Infection in the Pakistani Population

Rani¹,

Nawaz²,

Arshad³

2020

PJZ

Self Cite

View full text Add to dashboard Cite

show abstract

“…Malaria is a grave parasite disease spread by mosquitoes that is one of the most widespread and dangerous infectious diseases in the tropics and subtropics. 1 Clinical symptoms of P. falciparum malaria differ from patient to patient, ranging from asymptomatic infections to life-threatening situations. 2 Malaria episodes begin as a result of the interplay between malarial toxins released during red blood cell rupture and the innate immune system's phagocytic cells.…”

Section: Introductionmentioning

confidence: 99%

“…26 Polymorphisms in the MAL gene influence the function of this adaptor protein. 1 This polymorphism has been linked to resistance to a variety of infectious illnesses, including tuberculosis (TB), bacterial septicaemia, invasive pneumococcal infection, 27 and autoimmune disorders such as systemic lupus erythematosus (SLE) and Behcet's disease. 28 The main objective of this paper was to investigate the effect of the rs8177374 (C/T) polymorphism of the MyD88adapter-like (MAL) gene on the severity of P. falciparum infection in Egyptian adults.…”

mentioning

confidence: 99%

Plasmodium falciparum Malaria Susceptibility and Severity: Influence of MyD88-Adaptor-Like Gene (rs8177374) Polymorphism

Ammar¹,

El-Hefnawy²,

Shehab-Eldeen³

et al. 2022

IDR

View full text Add to dashboard Cite

Background: MyD88-adapter-like (MAL), as an essential adapter protein for a variety of TLRs (Toll-like receptors), modulates the inflammatory response. Many infectious illnesses are influenced by single nucleotide polymorphisms (SNPs) that modify MAL function. We aimed to examine the influence of the MAL rs8177374 polymorphism on Plasmodium falciparum malaria susceptibility and severity. Patients and Methods: Samples from 141 Plasmodium falciparum malaria patients and 147 healthy controls were used in the study. Patients were subdivided into mild and severe groups based on their clinical results, as defined by the World Health Organization (WHO). Genotypes for MAL rs8177374 were identified by allele-specific PCR technique, and TNF-alpha and IL-12 levels were measured using ELISA. Results: The MAL rs8177374 (CT) genotype is associated with an increased risk of malaria (OR: 2.52; 95% CI: 1.44-4.41). Furthermore, the CT and TT genotypes gave considerable protection against severe malaria (OR: 0.07; 95% CI: 0.03-0.19 and OR: 0.03; 95% CI: 0.007-0.1 respectively). And the T allele was linked to a higher risk of malaria (OR: 1.7; 95% CI: 1.18-2.5), while protecting patients from severe malaria (OR: 0.135; 95% CI: 0.07-0.3). Mutants (CT and TT) have greater TNF-alpha and IL-12 levels compared to wild-type (CC). Conclusion: Malaria risk is linked to single nucleotide polymorphism in the MyD88-adaptor-like gene. People with the MAL rs8177374 mutant variant may be less likely to get severe malaria.

show abstract

Unravelling the influence of host genetic factors on malaria susceptibility in Asian populations

Gupta,

Skjefte,

Muppidi

et al. 2024

Acta Tropica

View full text Add to dashboard Cite

Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population

Abstract: MyD88-adaptor-like/TIR domain containing adaptor protein polymorphism for single nucleotide polymorphism rs8177374 is related with the susceptibility of malaria.

Cited by 7 publications

References 37 publications

Association of TIR Domain Containing Adaptor Protein (TIRAP) Gene Variant rs8177400 with Susceptibility and Clinical Outcomes of Plasmodium Infection in the Pakistani Population

Association of TIR Domain Containing Adaptor Protein (TIRAP) Gene Variant rs8177400 with Susceptibility and Clinical Outcomes of Plasmodium Infection in the Pakistani Population

Plasmodium falciparum Malaria Susceptibility and Severity: Influence of MyD88-Adaptor-Like Gene (rs8177374) Polymorphism

Unravelling the influence of host genetic factors on malaria susceptibility in Asian populations

Contact Info

Product

Resources

About