Oxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism

Oliveira, Yanaihara Pinchemel Amorim de; Pontes-de-Carvalho, Lain Carlos; Couto, Ricardo David; Noronha-Dutra, Alberto A.

doi:10.1016/j.bjid.2016.11.004

Cited by 33 publications

(36 citation statements)

References 27 publications

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“…It is known that in sepsis, endogenous antioxidant capacity decreases and cell damage occurs as a result of the formation of oxidant/antioxidant imbalance and free radicals increase in this situation which is defined as oxidative stress (Macdonald, Galley, & Webster, 2003;Oliveira, Pontes-de-Carvalho, Couto, & Noronha-Dutra, 2017;Prauchner, 2017). MDA is one of the most important markers of oxidative stress.…”

Section: Ta B L Ementioning

confidence: 99%

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

et al. 2020

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Chrysin (CR) is a flavone found in propolis and many plants. Lipopolysaccharide (LPS) is a component of the cell wall of gram‐negative bacteria that causes sepsis. The purpose of this study was to investigate the effects of CR on LPS‐induced sepsis in rats. LPS intraperitoneal and a single dose and CR were given orally for 10 days. Rats were sacrificed, blood samples were taken, liver, lung, and kidney tissues were dissected, homogenized, and histopathological analysis was carried out. When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin‐1 beta (IL‐1β), interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and levels of malondialdehyde (MDA) in tissues. CR also increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) in tissues. Histopathological findings were consistent with biochemical findings. Conclusion, CR could reduce the oxidative stress markers and cytokines in sepsis. Practical applications Our approach is to determine the antioxidant and anti‐inflammatory effects of chrysin, known as a flavolonoid, which are found in many plants and foods such as honey and propolis. In this study, experimental sepsis model was created using LPS. According to the results of the study, CR can attribute to the ameliorating of oxidative damage in tissues (lung, liver, and kidney) and it can suppress the sepsis‐associated acute tissue injury via reduction of inflammation in rats. Even, CR can be used as a pharmacological agent in inflammatory diseases caused by other sources and in many cases causing oxidation.

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Section: Ta B L Ementioning

confidence: 99%

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

et al. 2020

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“…Oxidative stress is the serious cause of organ disability in critically ill patients (Ghashut et al, 2017). Reducing the antioxidant capacity (Rogobete et al, 2017) in these patients due to inefficient oxidative phosphorylation (Lorente et al, 2018) leads to an increase in free radicals (Oliveira, Pontes-de-Carvalho, Couto, & Noronha-Dutra, 2017), which is actually a possible mechanism for damage caused by the sepsis (Kumar et al, 2018). Some natural compounds and herbal derivatives have anti-inflammatory and antioxidant effects that can improve sepsis symptoms, such as zinc (Ganatra et al, 2017), magnesium (Esen et al, 2004), Q10 (Abitagaoglu et al, 2015), and curcumin (Chen, Lu, et al, 2018).…”

mentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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“…Red blood cells rheological changes can alter RDW in septic patients [13]. Mechanisms of changes in shape (sphericity), volume and deformability are still not completely understood [13], but several have been proposed in septic patients: phosphatidylserine redistribution on the outer red blood cell membrane leaflet [14,15], alterations of RBC sialic acid membrane content [16,17], band 3 protein phosphorylation [18], redox imbalances [19][20][21], calcium [22], 2,3-diphosphoglycerate [23] and adenosine triphosphate [24] homeostasis alterations and nitric oxide pathway modulation [25,26]. Also, inflammatory response indirectly modulates hematopoiesis through abnomal iron metabolism, increased hemolysis and decreased erythrocyte life span which will lead, in turn, to an increased release of the immature forms into the bloodstream [19].…”

Section: Possible Pathophysiological Mechanisms Explaining Rdw Changementioning

confidence: 99%

The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

Moisa

Negoiță

Corneci

2019

Central European Journal of Clinical Research

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Red blood cell distribution width (RDW) is a hematological parameter usually measured with every complete blood count. Its place in daily practice is mainly in the differential diagnosis of anemia, but nowadays, researchers are focused on different approaches for the erythrocyte’s changes in function and morphology.Sepsis and its most advanced form, septic shock, induces profound disturbances into organ system’s function and morphology. The red blood cells physiology and structure are directly and indirectly altered by these im balances produced in sepsis. RDW was studied in many diseases, like acute heart failure, acute stroke, inflammatory bowel diseases, chronic lung diseases and cancer, but also in sepsis. Its changes are seen to be mainly associated with prognosis. Higher values of RDW are correlated with mortality and severity of illnes in septic and all-cause critically ill patients. RDW was studied also as an independent variable in different predictive scores and some studies suggest it should be introduced in the scores use on a daily basis in critical care settings and emergency departments.In this review we will focus on how RDW was associated with mortality and severity of illness in the recent literature, as an independent prognosis factor and as a component part in different predictive and severity scores.

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Oxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism

Cited by 33 publications

References 27 publications

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

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