Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies

Majidiani, Hamidreza; Dalvand, Sahar; Daryani, Ahmad; Galván-Ramírez, María de la Luz; Foroutan, Masoud

doi:10.1016/j.bjid.2016.09.002

Cited by 53 publications

(40 citation statements)

References 26 publications

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“…On the other hand, findings in favor of an association between T. gondii seropositivity and diabetes mellitus include a high seroprevalence of T. gondii infection found in patients with diabetes mellitus in general hospitals in Daejeon, Korea [16], and a significantly higher seroprevalence of T. gondii infection in patients with diabetes than in healthy controls found in an age- and gender-matched case-control study in Iran [19]. In addition, a meta-analysis of seven studies about the association of chronic toxoplasmosis and diabetes mellitus concluded that chronic toxoplasmosis was a possible risk factor for type 2 diabetes mellitus [20]. …”

Section: Discussionmentioning

confidence: 99%

“…In an age- and gender-matched case-control study of 91 diabetic cases and 93 healthy non-diabetic controls in Iran, researchers found a higher seroprevalence of IgG antibodies against T. gondii in diabetic patients than in healthy controls [19]. In a meta-analysis of studies on the association between chronic toxoplasmosis and diabetes mellitus, researchers found that chronic toxoplasmosis was a possible risk factor for type 2 diabetes mellitus, and no association between T. gondii and type 1 diabetes mellitus [20]. Since results of studies about the association of T. gondii infection and diabetes mellitus are controversial, we decided to perform a matched case-control study to determine whether T. gondii seropositivity is associated with diabetes mellitus in subjects attending in a public health institution in Durango City, Mexico.…”

Section: Introductionmentioning

confidence: 99%

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Lack of Association Between Toxoplasma gondii Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population

et al. 2017

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BackgroundVery little is known about the association between infection with Toxoplasma gondii (T. gondii) and diabetes mellitus. We perform an age- and gender-matched case-control study to determine the association of T. gondii infection and diabetes mellitus.MethodsCases included 156 patients with diabetes mellitus and 156 controls without diabetes mellitus who attended in two public clinics in Durango City, Mexico. Sera of cases and controls were tested for the presence of anti-Toxoplasma IgG and IgM antibodies using commercially available enzyme-linked fluorescence assays (ELFA).ResultsAnti-T. gondii IgG antibodies were found in 10 (6.4%) of the 156 cases and in five (3.2%) of the 156 controls (odds ratio (OR): 2.06; 95% confidence interval (CI): 0.69 - 6.19; P = 0.18). The frequency of high (> 150 IU/mL) anti-T. gondii IgG levels in seropositive cases (1/10: 10.0%) was comparable to the one (1/5: 20%) in seropositive controls (OR: 0.44; 95% CI: 0.02 - 9.03; P = 1.00). None of the 10 cases and five controls with seropositivity to anti-T. gondii IgG antibodies were positive for anti-T. gondii IgM antibodies. Stratification by gender showed similar frequencies of T. gondii infection in female cases (7/107: 6.5%) and female controls (4/107: 3.7%) (OR: 1.80; 95% CI: 0.51 - 6.34; P = 0.53), and in male cases (3/49: 6.1%) and male controls (1/49: 2.0%) (OR: 3.13; 95% CI: 0.31 - 31.19; P = 0.61).ConclusionsWe conclude that there is not serological evidence of an association between T. gondii infection and diabetes mellitus in the studied subjects in Durango City, Mexico. Further studies to elucidate the role of T. gondii in diabetes should be conducted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lack of Association Between Toxoplasma gondii Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population

et al. 2017

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“…[14][15][16][17] Moreover, chronic toxoplasmosis is strongly correlated to autoimmune diseases. 18,19 Routine diagnostic methods for toxoplasmosis generally pertain to serologydependent experiments such as enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence assay (IFA) in order to discern the T. gondii-specific antibodies, i.e. IgM or IgG.…”

Section: Introductionmentioning

confidence: 99%

Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran

Foroutan

Dalvand

Daryani

et al. 2018

Alexandria Journal of Medicine

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a b s t r a c tToxoplasmosis is a neglected parasitic disease with global distribution in warm-blooded vertebrates and high prevalence among different human societies. We contrived a systematic review and meta-analysis on the prevalence of toxoplasmosis in Iran. Following the general methodology recommended for systematic reviews and meta-analysis, four English and three Persian electronic databases were explored up to April 2016. Out of 105,139 examined samples of different hosts, the weighted overall prevalence was 37% (95% CI = 31-43). Due to the significant heterogeneity (I 2 = 81.9%) the random-effects model was used. The pool estimated prevalence of toxoplasmosis in human intermediate hosts, animal intermediate hosts, and definitive hosts was 43% (95% CI = 38-47), 26 (95% CI = 17-35) and, 34% (95% CI = 22-46), respectively. Our results represent that regular inspection in food industries, improved screening programs using standard diagnostic assay as well as distinguishing toxoplasmosis condition in other zoonotic hosts are extremely recommended for better disease management in Iran. Ó 2017 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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“…Based on recent studies, chronic toxoplasmosis may associated with autoimmune and neurodegenerative disorders [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran

Yousefi

Foroutan

Salehi

et al. 2017

JAD

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Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies

Cited by 53 publications

References 26 publications

Lack of Association Between Toxoplasma gondii Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population

Lack of Association Between Toxoplasma gondii Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population

Rolling up the pieces of a puzzle: A systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran

Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran

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