Emergent diseases in emergent countries: we must study viral ecology to prevent new epidemics

Ellwanger, Joel Henrique

doi:10.1016/j.bjid.2016.02.003

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Currently, the prevention and control of infectious diseases should be approached as a global strategy, in which human, animal, and environmental factors are integrated ( 152 – 154 ), allied to the evaluation of the genomic characteristics of the pathogens ( 155 , 156 ). Among the human factors that should be taken into consideration, the investigation of genetic features that alter the susceptibility to infection and progression of viral diseases is essential for the prevention and clinical management of infectious diseases in specific human populations ( 157 – 159 ) (Figure 3 ).…”

Section: Emerging Topicsmentioning

confidence: 99%

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

2018

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MicroRNAs (miRNAs) are single-stranded sequences of non-coding RNA with approximately 22 nucleotides that act posttranscriptionally on gene expression. miRNAs are important gene regulators in physiological contexts, but they also impact the pathogenesis of various diseases. The role of miRNAs in viral infections has been explored by different authors in both population-based as well as in functional studies. However, the effect of miRNA polymorphisms on the susceptibility to viral infections and on the clinical course of these diseases is still an emerging topic. Thus, this review will compile and organize the findings described in studies that evaluated the effects of genetic variations on miRNA genes and on their binding sites, in the context of human viral diseases. In addition to discussing the basic aspects of miRNAs biology, we will cover the studies that investigated miRNA polymorphisms in infections caused by hepatitis B virus, hepatitis C virus, human immunodeficiency virus, Epstein–Barr virus, and human papillomavirus. Finally, emerging topics concerning the importance of miRNA genetic variants will be presented, focusing on the context of viral infectious diseases.

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Section: Emerging Topicsmentioning

confidence: 99%

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

2018

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“…This is important because only indentifying the pathogens, their hosts, and their potential to infect different species, will it be possible to prevent and combat new diseases and future potential epidemics that might affect humans 32 . Studies on zoonotic diseases may support strategies for controlling the circulation of pathogens between human and wild/domestic animals.…”

Section: Perspectives On the Ecology And Surveillance Of The Arenavirmentioning

confidence: 99%

Keeping track of hidden dangers - The short history of the Sabiá virus

Ellwanger

2017

Rev. Soc. Bras. Med. Trop.

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Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome. The lack of monitoring strategies to identify pathogens with the potential to cause outbreaks or epidemics is another problem in Brazil and other developing countries. In this article, we present the history of the Sabiá virus (SABV), a pathogen that was described in the 1990s in Brazil. Several aspects of the biology and ecology of the SABV remain unknown. The SABV has the potential to cause hemorrhagic fever in humans. To date, four cases of human infections have been reported worldwide; two were naturally acquired (both in Brazil), whereas the other two were linked to occupational exposure in the laboratory environment (one in Brazil and one in the USA). In this review, we summarize the basic biological and ecological characteristics of the SABV. This is the first work to gather all available data on the historical aspects involving the cases of SABV infection along with an update on its characteristic features.

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“…• Ecology may become important as soon as hosts and vectors are important for spreading a disease [22,73] • Climate may have a significant influence on the spreading of an epidemics [18,29].…”

Section: Representation Of Influencing Areasmentioning

confidence: 99%

Some Remarks about the Complexity of Epidemics Management

Draeger¹

2017

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Recent outbreaks of Ebola, H1N1 and other infectious diseases have shown that the assumptions underlying the established theory of epidemics management are too idealistic. For an improvement of procedures and organizations involved in fighting epidemics, extended models of epidemics management are required. The necessary extensions consist in a representation of the management loop and the potential frictions influencing the loop. The effects of the nondeterministic frictions can be taken into account by including the measures of robustness and risk in the assessment of management options. Thus, besides of the increased structural complexity resulting from the model extensions, the computational complexity of the task of epidemics management -interpreted as an optimization problem -is increased as well. This is a serious obstacle for analyzing the model and may require an additional preprocessing enabling a simplification of the analysis process. The paper closes with an outlook discussing some forthcoming problems.

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Emergent diseases in emergent countries: we must study viral ecology to prevent new epidemics

Cited by 7 publications

References 2 publications

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

Keeping track of hidden dangers - The short history of the Sabiá virus

Some Remarks about the Complexity of Epidemics Management

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