Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Abstract

Human papillomavirus (HPV) infection is common in sexually active women and viral persistence may cause intraepithelial lesions and eventually progress to cervical cancer (CC). The present study aimed to investigate epidemiological factors related to HPV infection and to evaluate viral persistence and CC precursor lesions frequencies in women from a city in the countryside of South Brazil. Three hundred women were recruited from a primary public health care clinic. The patients were interviewed and underwent sampling with cervical brushes for HPV-DNA detection/typing by a PCR-based assay and cytological analysis by Pap smear test. HPV was detected in 47 (15.7%) women. HPV infection was significantly associated with young age (<30 years) and low socio-economic status. Seventeen (5.7%) women presented cytological abnormalities, three of them with precursor CC intraepithelial lesions. A subgroup of 79 women had been previously analyzed and thirteen (16.4%) were persistently infected, two with precursor CC intraepithelial lesions and high-risk HPV types infection (both of them without cervical abnormalities in the first exam). In conclusion, HPV infection was associated with young age (<30 years) and low family income; viral persistence was low (16.4%) but related to CC precursor lesions; and HPV-DNA high risk types detection would help to screen CC in the population.

Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China

“…The prevalence of CC has been reported to be significantly higher among the women who had early marriage, early pregnancy and more parturitions 28, 29. Our data shows that the HPV infection rate of the patients who had their first sexual activity at or before the age of 20 is obviously higher than that in other age groups, generally in line with the opinion that having sexual intercourse at an earlier age might increase the risk for CC.…”

Caracterização e relação de leveduras do gênero Candida isoladas das mucosas oral e vaginal de mulheres com lesões causadas por HPV de alto risco para câncer do colo do útero

“…A média de idade das participantes com HPV de alto risco para câncer do colo do útero estudada foi de 36 anos ± 11,4, um pouco acima dos dados encontrados em outros estudos (Silva et al, 2014;Coser et al, 2016;Shaw et al, 2016) que variaram de 28,52 a 33,9 anos, e de acordo com Coser et al Já o uso do DIU, segundo alguns estudos possui associação protetora para infecção por HPV, o que pode ser explicado através da alta resposta imune gerada pelo DIU no colo uterino gerando uma rápida eliminação de infecções (Ortiz;Croxatto, 2007). Por outro lado, outros estudos tem demonstrado que infecções crônicas podem promover o desenvolvimento de lesões pré-malignas de alto risco relacionadas ao HPV (Fernandes et al, 2015).…”

“…É uma das causas mais comuns de doenças sexualmente transmissíveis, possuindo a capacidade de infectar o tecido epitelial; e cerca de 5 a 40% das mulheres sexualmente ativas apresentam positividade em testes moleculares para HPV (Coser et al, 2016;Shaw et al, 2016). (Coser et al, 2016;INCA, 2016).…”

“…A persistência do HPV e a progressão para o câncer do colo do útero dependem de vários fatores, como idade, tabagismo, uso prolongado de contraceptivos, comportamento sexual e co-infecção com outros agentes infecciosos de transmissão sexual, entre outras (Coser et. al., 2016).…”

“…Pelo menos 13 tipos de HPV são considerados oncogênicos, apresentando maior risco ou probabilidade de provocar infecções persistentes e estar associados a lesões precursoras. Dentre os HPV de alto risco oncogênico, os tipos 16 e 18 estão presentes em 70% dos casos do câncer do colo do útero (Coser et al, 2016;INCA, 2016;Sung et al, 2016).…”