Effectiveness of the prevention of mother-to-child HIV transmission in Bahia, Brazil

Patricio, Fátima Rejane Lemos; Rutherford, George W; Barreto, José Henrique Silva; Rodamilans, Cynthia; Badaró, Roberto

doi:10.1016/j.bjid.2015.06.006

Cited by 6 publications

(4 citation statements)

References 15 publications

(15 reference statements)

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“…These data corroborate the findings of a study that assessed MTCT reduction in Brazil, in the period of 1994 to 2016, stratified the country’s prognostics per region and found that the Northeastern region 5 , 24 - 26 had the highest number of states with unfavorable perspective, followed by the Northern 26 , 27 and the Central-western 19 , 26 regions.…”

Section: Discussionsupporting

confidence: 87%

Vertical transmission of HIV to neonates in a reference hospital in Northeastern Brazil from 2013 to 2017

Figueredo,

Monteiro,

Batista

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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The aim of this study was to estimate the rate of Mother-to-child Transmission (MTCT) of HIV to neonates in a reference university hospital in Sao Luis city, the capital of Maranhao State (MA), evaluating MTCT-associated factors. A retrospective cohort study based on data from the Notifiable Diseases Data System (SINAN) was carried out and included all HIV-exposed neonates notified from 2013 to 2017 by the university hospital. The study population comprised 725 HIV-exposed neonates, of whom 672 neonates were exposed and uninfected, and 53 were exposed and infected. The estimated rate of MTCT in the period of 2013 to 2017 was 7.3%. Most pregnant women were ≥ 20 years old (86.9%), reported ≥ 8 years of schooling (53.2%), reported full-time or independent paid work (46.9%) and were residents in other cities of the state (61.7%). Regarding healthcare, 86.3% received prenatal care, 74.6% received Antiretroviral Therapy (ART) as prophylaxis during pregnancy, 81.8% received ART prophylaxis during childbirth and 78.1% underwent cesarean section. Among the neonates, 92.8% received ART prophylaxis and 94.3% were not breastfed. Despite these variables, the 7.3% MTCT rate found in this study makes it clear that the interventions recommended by the Ministry of Health were not fully adopted.

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Section: Discussionsupporting

confidence: 87%

Vertical transmission of HIV to neonates in a reference hospital in Northeastern Brazil from 2013 to 2017

Figueredo,

Monteiro,

Batista

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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“…The use of intravenous AZT during delivery was also directly associated with a reduction in the rates of MTCT 13,14,17,37. In a study by Cruz Gouveia et al 16 in the northeast, 75% of pregnant women received intrapartum AZT between 2000 and 2009, and the rate of MTCT decreased from 21.8% to 4.6% in women who received AZT during delivery.…”

Section: Resultsmentioning

confidence: 97%

“…In different regions of the country, failure to attend prenatal care 13,17,37, late maternal diagnosis 13,37, and an incomplete ART regimen during pregnancy 13,16,17,37 were highlighted as significant risk factors for MTCT. A retrospective study conducted between 2000 and 2009 in the northeast of the country in the state of Pernambuco demonstrated the importance of prenatal care in the prophylaxis of vertical HIV transmission.…”

Section: Resultsmentioning

confidence: 99%

Review of the missed opportunities for the prevention of vertical transmission of HIV in Brazil

Guimarães¹,

Lovero²,

Avelar³

et al. 2019

Clinics

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OBJECTIVE:The present literature review aims to highlight gaps in the treatment of preventative mother-to-child HIV transmission and the risk factors in Brazil.METHODS:Among the 425 articles identified in SciELO and PubMed searches, 59 articles published between 1994 and 2016 were selected for reading and data extraction, and 33 articles were included in the present review.RESULTS:The rates of vertical HIV transmission described in the studies varied widely, from 1.8% to 27.8%, with a significant reduction over the years. However, recent rates were also found to be variable in different regions of Brazil, and despite the significant reduction in mother-to-child transmission, many gaps remain in prevention services. A failure to attend prenatal care is the main factor associated with the increased risk of vertical transmission of HIV, hindering early maternal diagnosis and the completion of preventative measures during the prenatal period and, often, the peripartum and postnatal periods. A small number of studies discussed the sociodemographic factors, including a low level of education for pregnant women and the inadequacies of health services, such as difficulties scheduling appointments and undertrained staff, associated with vertical transmission. As such, the current challenge is to better define the sociodemographic and infrastructural factors that increase the risk of mother-to-child transmission of HIV to provide the necessary investments to promote an earlier inclusion of these populations in prevention services.CONCLUSIONS:This review may serve as a guide for future programs to focus efforts on the prevention of vertical HIV transmission.

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“…En Brasil, donde la prevalencia de infección en la mujer embarazada es 0,38% superior a la nuestra, la utilización de HAART en el embarazo se incrementó en Río Grande del Sur (segundo lugar de mayor notificación de mujeres embarazadas infectadas de Brasil) a 73,3% entre los años 2005 y 2011 con cifras de TMI de 2,9% (22) . En un centro de referencia VIH -SIDA de Bahía, la TMI fue de 8,2% entre los años 2005 y 2008 (23) .…”

Section: Discussionunclassified

Transmisión vertical del virus de la inmunodeficiencia humana en mujeres usuarias del Centro Hospitalario Pereira Rossell; Uruguay, 2012-2014. Resultados de la aplicación del protocolo zidovudina - nevirapina en niños uruguayos

Castro

Rodríguez

Gazano

2018

RMU

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Introducción: el embarazo controlado y la supresión del amamantamiento son estrategias para disminuir la transmisión vertical (TMI) del virus de inmunodeficiencia humana (VIH). La profilaxis al neonato con zidovudina o zidovudina con nevirapina se utiliza según el riesgo de TMI. Objetivo: describir la TMI entre los años 2012 y 2014 en el Centro Hospitalario Pereira Rossell (CHPR), su relación con la carga viral materna y el cumplimiento de la recomendación AZT-NVP al neonato. Material y método: estudio descriptivo en el Centro de Referencia Obstétrico-Pediátrico VIH-Sida desde 1°de setiembre de 2012 al 31de diciembre 2014. Se incluyeron los recién nacidos de mujeres con carga viral detectable o indetectable al momento del parto. Se registró la administración de zidovudina-nevirapina. Se determinó la transmisión vertical. Resultados: se incluyeron 162 mujeres, 86 con carga viral detectable o desconocida y 76 indetectable. Las primeras tuvieron 88 hijos y las segundas 76. La TMI global fue de 4,9%; 9% en el primer grupo y 0% en el segundo. Se registró asociación entre TMI y CV materna (p <0,05). La administración de AZT-NVP se indicó en 46,5% de los niños. De los ocho niños infectados, la TMI fue intraútero en cinco. En los tres restantes, dos recibieron AZT y otro ninguna profilaxis. Discusión y conclusiones: la mitad de las mujeres no controló bien su embarazo. La TMI promedio fue de 4,9%. De los ocho infectados, cinco fueron intraútero; solo un diagnóstico y tratamiento precoces lo hubiesen evitado. El protocolo AZT-NVP no se utiliza en forma adecuada. Quizá su aplicación en los tres niños restantes hubiera evitado la infección.

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Effectiveness of the prevention of mother-to-child HIV transmission in Bahia, Brazil

Abstract: Low levels of antenatal screening and access to prevention of mother-to-child transmission were significant limitations in the cascade of prevention of mother-to-child transmission at our center in this period.

Cited by 6 publications

References 15 publications

Vertical transmission of HIV to neonates in a reference hospital in Northeastern Brazil from 2013 to 2017

Vertical transmission of HIV to neonates in a reference hospital in Northeastern Brazil from 2013 to 2017

Review of the missed opportunities for the prevention of vertical transmission of HIV in Brazil

Transmisión vertical del virus de la inmunodeficiencia humana en mujeres usuarias del Centro Hospitalario Pereira Rossell; Uruguay, 2012-2014. Resultados de la aplicación del protocolo zidovudina - nevirapina en niños uruguayos

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