Raoultella ornithinolytica causing fatal sepsis

Kaya, Selçuk; Bayramoğlu, Gülçin; Sönmez, Mehmet; Köksal, İftihar

doi:10.1016/j.bjid.2014.12.010

Cited by 22 publications

(28 citation statements)

References 6 publications

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“…Although recovery was achievable in many of these cases, death occurred in many of them and several reported cases were described in patients with malignant conditions or immunosuppression. Kaya et al (2015) reported a case of febrile neutropenia with R. ornithinolytica bacteremia in a 37-year-old male patient with acute lymphocytic leukemia. 77 The clinical outcome in this case was fatal despite aggressive antibiotic combinations using piperacillin/tazobactam, amphotericin-B, tigecycline, amoxicillin/clavulanate and ciprofloxacin.…”

Section: Bloodstream and Other Infectionsmentioning

confidence: 99%

Raoultella ornithinolytica: Emergence and Resistance

Hajjar¹,

Ambaraghassi²,

Sebajang³

et al. 2020

IDR

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Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the genus Raoultella in 2001. R. ornithinolytica is usually found in water environments and soil, and due to its ability to convert histidine to histamine, it has been associated with histamine poisoning in humans. R. ornithinolytica is an emerging entity in human infections, with several reports of virulent infections in comorbid at-risk patients. Increasing reports are potentially due to better and more precise identification tools. The objective of this article is to provide a comprehensive review of reported cases of R. ornithinolytica infections, the emergent virulence of described multiresistant strains, and an overview of currently used identification methods.

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Section: Bloodstream and Other Infectionsmentioning

confidence: 99%

Raoultella ornithinolytica: Emergence and Resistance

Hajjar¹,

Ambaraghassi²,

Sebajang³

et al. 2020

IDR

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“…Raoultella ornithinolytica is an environmental Gram-negative bacilli that produces histamine, which leads to poisoning by ingestion of contaminated fish (Kanki et al 2002). In humans, it may cause fever-like syndrome, urinary tract infections, cutaneous infections in diabetics, and even septicaemia in immunocompromised individuals (Morais et al 2009;Solak et al 2011;Kaya et al 2015;Nakasone et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial potential of phytochemicals alone or in combination with antimicrobials against fish pathogenic bacteria

et al. 2018

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“…Se han descrito casos aislados de multirresistencia, que es uno de los factores que más contribuyen a su mortalidad. 9 De los dos microorganismos, la mayoría de las especies resistentes descritas se refieren a Leclercia, 14 productora de beta-lactamasas. Esta última es sensible a todos los antimicrobianos efectivos contra Enterobacteriaceae, salvo fosfomicina, a la cual presenta resistencia natural (aspecto característico y que puede ayudar a distinguir Leclercia de E. coli).…”

Section: Discussionunclassified

Infección asociada a catéter por Leclercia adecarboxylata y Raoultella ornithinolytica en un paciente con enfermedad mitocondrial

et al. 2019

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RESUMENLeclercia adecarboxylata y Raoultella ornithinolytica constituyen bacterias Gram-negativas emergentes. Los casos descritos son excepcionales. En los últimos años, las mejoras en las técnicas de diagnóstico microbiológico han permitido su detección y conocimiento. Se presenta el caso de un niño de 11 años con enfermedad mitocondrial, portador de catéter venoso central de larga duración, que desarrolló dos episodios de sepsis por L. adecarboxylata y R. ornithinolytica, respectivamente. En los casos de infección asociada al uso de catéter, es posible, en ocasiones, el tratamiento sin su retirada con evolución favorable. Es importante reconocer L. adecarboxylata y R. ornithinolytica como patógenos de diagnóstico cada vez más frecuentes, sobre todo, en pacientes inmunodeprimidos o con patologías crónicas asociadas. Palabras clave: sepsis, Enterobacteriaceae, infecciones relacionadas con catéteres, enfermedades mitocondriales, pediatría.ABSTRACT Leclercia adecarboxylata and Raoultella ornithinolytica are emergent Gram-negative bacteria. Infections caused by these microorganisms are exceptional. Improvement of microbiologist techniques in the last years has enabled their detection and more accurate knowledge. We present the case of an 11-year-old boy with mitochondrial disease with a longterm central catheter who suffered from two sepsis caused by L. adecarboxylata and R. ornithinolytica, respectively. In catheter-related infections, sometimes it is possible to provide antimicrobial treatment without removal of catheter with good results, as in our patient. It is important to recognize L. adecarboxylata and R. ornithinolytica like increasingly frequent pathogenic bacteria, mostly in immunocompromised or chronic patients.

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Raoultella ornithinolytica causing fatal sepsis

Cited by 22 publications

References 6 publications

<p><em>Raoultella ornithinolytica</em>: Emergence and Resistance</p>

<p><em>Raoultella ornithinolytica</em>: Emergence and Resistance</p>

Antibacterial potential of phytochemicals alone or in combination with antimicrobials against fish pathogenic bacteria

Infección asociada a catéter por Leclercia adecarboxylata y Raoultella ornithinolytica en un paciente con enfermedad mitocondrial

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