Frequency of adverse events associated to antiretroviral drugs in patients starting therapy in Salvador, Brazil

Vendruscolo, Ornela; Majdalani, Mateus; Mota, Rafael; Luz, Estela; Brites, Carlos

doi:10.1016/j.bjid.2014.09.008

Cited by 1 publication

(3 citation statements)

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“…Smoking, in particular, is usually observed in a higher frequency in PLHIV than in the population without HIV. However, its frequency is significantly influenced by the study site [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. In our population, 11.3% were current smokers and 23.8% had already used tobacco, results similar to those found in other Brazilian studies [ 13 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In total, about 80.8% of the sample had some altered lipid fraction. Median time since HIV diagnosis was 15.5 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) years and the median time of antiretroviral therapy was 15 (7-21) years. Most (52.8%) patients reported being MSM, 26.8% declared themselves as heterosexual and in 20.4% route of infection was undefined.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…The use of some antiretroviral drugs, like those belonging to protease inhibitors (PI) and reverse transcriptase inhibitors classes, is related to lower levels of high-density lipoprotein (HDL), increase in total cholesterol (TC) and triglycerides (TG) and development of systemic arterial hypertension (AH). All these changes increase the CVR of these patients and the likelihood of outcomes such as acute myocardial infarction (AMI), stroke and congestive heart failure (CHF) [ 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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High Concordance between D:A:Dr and the Framingham Risk Score in Brazilians Living with HIV

Souza

Valadares

Dias

et al. 2023

Viruses

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People living with HIV (PLHIV) have twice the risk of developing cardiovascular diseases, making it essential to identify high cardiovascular risk (CVR). However, there is no validated CVR calculator for PLHIV in Brazil. We performed a cross-sectional study with 265 individuals living with HIV, aged 40 to 74 years, to assess the agreement between three CVR scores: Framingham Risk Score (FRS), Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score, and a specific for PLHIV, Reduced Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:Dr). We assessed agreement using the weighted Kappa coefficient and the Bland-Altman plot. The median age was 52 years (47–58), 58.9% were men, 34% were hypertensive and 8.3% had a detectable viral load. There was an almost perfect agreement between D:A:Dr x FRS (k = 0.82; 95% CI 0.77–0.87; p < 0.001), and substantial agreement between FRS vs. ASCVD (k = 0.74; 95% CI 0.69–0.79; p < 0.001) and between D:A:Dr vs. ASCVD (k = 0.70; 95% CI 0.64–0.76; p < 0.001). The Bland-Altman plot revealed greater discordance between scores as the CVR increased. Our results suggest that the FRS and the D:A:Dr are adequate to classify the CVR in this population, and the D:A:Dr score can be used as an alternative to the FRS in Brazil, as other international guidelines have already advocated.

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